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Full record GDS4172

Effect of protease-resistant (PML-RAR)α on U937 cell line

Analysis of U937 cells transfected with GFP-(PML-RAR)α (PR) or GFP-PR2VR (cleavage-resistant mutant) and GFP-sorted at 6 and 9 hrs. Neutrophil elastase (NE) cleaves PR, the fusion protein that initiates acute promyelocytic leukemia. Results provide insight into leukemogenicity of NE-resistant PR.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 genotype/variation, 2 time sets
Platform:
GPL570
Series:
GSE21550
12 Samples
Download data: CEL
DataSet
Accession:
GDS4172
ID:
4172

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