Effect of protease-resistant (PML-RAR)α on U937 cell line - - GEO DataSets

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Effect of protease-resistant (PML-RAR)α on U937 cell line

Analysis of U937 cells transfected with GFP-(PML-RAR)α (PR) or GFP-PR2VR (cleavage-resistant mutant) and GFP-sorted at 6 and 9 hrs. Neutrophil elastase (NE) cleaves PR, the fusion protein that initiates acute promyelocytic leukemia. Results provide insight into leukemogenicity of NE-resistant PR.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 genotype/variation, 2 time sets

Platform:: GPL570
Series:: GSE21550
12 Samples

Download data: CEL

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Accession:: GDS4172

ID:: 4172

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