GEO DataSets

Analysis of early stages of myogenesis. C2C12 myoblasts induced to differentiate and examined during cell proliferation (days -2 to -1), at cell cycle withdrawal (day 0) and during myogenic fusion and maturation of multinucleated myotubes (days 2 to 10).

Organism:

Mus musculus

Type:

Expression profiling by array, count, 7 time sets

Platform:

GPL83

Series:

GSE990

21 Samples

Download data: CEL, EXP, RPT

(Submitter supplied) In this study, Affymetrix MG_U74Av2 and MG_U74Cv2 GeneChips were used to analyze gene expression over a 12 day time course in C2C12 myoblasts induced to differentiate in vitro. Triplicate cultures were studied during cell proliferation (days -2 and -1), at cell cycle withdrawal (day 0) and during myogenic fusion and maturation of multinucleated myotubes (days 2, 4, 6, 8, 10). The manuscript associated to this work is Tomczak et al., FASEB J., 2003 Dec 19. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS587

Platform:

GPL83

21 Samples

Download data: CEL, EXP, RPT

(Submitter supplied) In this study, Affymetrix MG_U74Av2 and MG_U74Cv2 GeneChips were used to analyze gene expression over a 12 day time course in C2C12 myoblasts induced to differentiate in vitro. Triplicate cultures were studied during cell proliferation (days -2 and -1), at cell cycle withdrawal (day 0) and during myogenic fusion and maturation of multinucleated myotubes (days 2, 4, 6, 8, 10). The manuscript associated to this work is Tomczak et al., FASEB J., 2003 Dec 19. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS586

Platform:

GPL81

24 Samples

Download data: CEL, EXP, RPT

Analysis of early stages of myogenesis. C2C12 myoblasts induced to differentiate and examined during cell proliferation (days -2 to -1), at cell cycle withdrawal (day 0) and during myogenic fusion and maturation of multinucleated myotubes (days 2 to 10).

Organism:

Mus musculus

Type:

Expression profiling by array, count, 8 time sets

Platform:

GPL81

Series:

GSE989

24 Samples

Download data: CEL, EXP, RPT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL1261 GPL6105

84 Samples

Download data: CEL

(Submitter supplied) Myogenesis is a tightly controlled process involving the transcriptional activation and repression of thousands of genes. Although many components of the transcriptional network are known for the later phases of myogenesis, relatively little work has described the transcriptional landscape within the first 24 hours, when myoblasts commit to differentiate. Through dense temporal sampling of differentiating C2C12 myoblasts, we identify 266 transcriptional regulators (TRs) whose expression is altered within the first 12 hours of myogenesis. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6105

36 Samples

Download data: TXT

(Submitter supplied) Analysis of Early Myogenesis Reveals an Extensive Set of Transcriptional Regulators Whose Knock-down Can Inhibit Differentiation Myogenesis is a tightly controlled process involving the transcriptional activation and repression of thousands of genes. Although many components of the transcriptional network are known for the later phases of myogenesis, relatively little work has described the transcriptional landscape within the first 24 hours, when myoblasts commit to differentiate. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

48 Samples

Download data: CEL

(Submitter supplied) Skeletal muscle contains long multinucleated and contractile structures known as muscle fibers, which arise from the fusion of myoblasts into nucleated myotubes during myogenesis. The myogenic regulatory factor (MRF) MYF5 is the earliest to be expressed during myogenesis and functions as a transcription factor in muscle progenitor cells (satellite cells) and myocytes. In mouse C2C12 myocytes, MYF5 is implicated in the initial steps of myoblast differentiation into myotubes. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

16 Samples

Download data: TXT

(Submitter supplied) During muscle differentiation, myogenesis sepcific genes are differentially regulated, including Lamins that function at least in maintenance of nuclear architecture and regulation of gene expression. We used microarrays to detail the global changes of gene expression in lamins and nuclear envelope assoicated proteins during myogenesis. Keywords: comparative, myogenesis

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2412

Platform:

GPL1261

6 Samples

Download data

Analysis of C2C12 skeletal myoblasts induced to differentiate into myotubes in vitro. Results provide insight into the role of nuclear envelope transmembrane proteins in myogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 development stage sets

Platform:

GPL1261

Series:

GSE4694

6 Samples

Download data

(Submitter supplied) GDF8 (myostatin) is a unique cytokine strongly affecting the skeletal muscle phenotype in human and animals. The aim of the present study was to elucidate the molecular mechanism of myostatin influence on the differentiation of mouse C2C12 myoblasts, using the global-transcriptome analysis with the DNA microarray technique. Treatment with exogenous GDF8 strongly affected the growth and development of C2C12 mouse myoblasts. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

4 Samples

Download data: TXT

(Submitter supplied) Background: Insulin's effect on protein synthesis (translation of transcripts) and post-translational modifications, especially those involving reversible modifications such as phosphorylation of various signaling proteins, are extensively studied. On the other hand, insulin's effect on the transcription of genes, especially of transcriptional temporal patterns, is not well investigated in the literature. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

53 Samples

Download data: CEL

(Submitter supplied) By using Hoechst staining techniques, we have previously shown that the C2C12 myogenic cell line contains a Side Population (SP) (Benchaouir et al, Exp Cell res, 2004) which is largely increased in the presence of FGF6 (Israeli et al, J Cellular Physiol, 2004). The experiment, compared transcriptional profiles from SP and MP (Main Population) cells from either C2C12 or FGF6-expressing C2C12.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL1091 GPL1063

35 Samples

Download data

(Submitter supplied) This study explores the profiles of genes expressed during conditional differentiation of inner ear hair cell precursors in vitro. The cell line UB/OC-1 was derived from mouse embryonic organs of Corti (Rivolta et al, Proc. R. Soc. Lond. B 265: 1595-1603, 1998) and it can be induced to differentiate upon a temperature shift. The study has been replicated in two separate populations of cells, named Exp A and Exp B. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS45 GDS51

Platforms:

GPL76 GPL75

32 Samples

Download data

Gene expression profile of differentiation of inner ear hair cell precursors in vitro. A conditionally immortal cell line derived from the mouse cochlea, UB/OC-1, examined from 0 to 14 days.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 12 time sets

Platform:

GPL76

Series:

GSE36

16 Samples

Download data

Gene expression profile of differentiation of inner ear hair cell precursors in vitro. A conditionally immortal cell line derived from the mouse cochlea, UB/OC-1, examined from 0 to 14 days.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 12 time sets

Platform:

GPL75

Series:

GSE36

16 Samples

Download data

(Submitter supplied) We use tag-based next generation sequencing analysis to quantify gene expression levels during myogenic differentiation and focused on the identifcation of novel 3' ends with DeepSAGE and novel 5' ends with DeepCAGE.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL9250

14 Samples

Download data: WIG

(Submitter supplied) Many stem cell populations exist in a quiescent state in vivo, exiting quiescence and entering the cell cycle in response to specific stimuli. In the case of skeletal muscle, the muscle stem cells (MuSCs, or “satellite cells”) are quiescent under normal homeostatic conditions and undergo activation and cell cycle entry in response to muscle fiber damage. Quiescent MuSCs are also much more potent than their proliferating progeny in assays of stem cell transplantation. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL13112 GPL21103

39 Samples

Download data: TXT

(Submitter supplied) Single-cell expression profiling by RNA-Seq promises to exploit cell-to-cell variation in gene expression to reveal regulatory circuitry governing cell differentiation and other biological processes. Here, we describe Monocle, a novel unsupervised algorithm for ordering cells by progress through differentiation that dramatically increases temporal resolution of expression measurements. This reordering unmasks switch-like changes in expression of key regulatory factors, reveals sequentially organized waves of gene regulation, and exposes regulators of cell differentiation. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL11154 GPL16791

384 Samples

Download data: TXT

(Submitter supplied) Differentially expressed genes along the paraxial mesoderm of 12 somite stage zebrafish embryos are identified

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL1319

12 Samples

Download data: CEL