GEO DataSets

Analysis of 7 patients with glioblastoma (GBM) treated at Memorial Sloan-Kettering Cancer Center, with survival > 48 months. These long-term survivors (LTSs) represent proneural, neural, classical, and mesenchymal subtypes of GBM. Results provide insight into molecular characteristics of GBM LTSs.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 4 disease state, 7 individual, 7 time sets

Platform:

GPL571

Series:

GSE54077

7 Samples

Download data: CEL

(Submitter supplied) Glioblastoma (GBM) is a highly aggressive type of glioma with poor prognosis. However, a small number of patients live much longer than the median survival. A better understanding of these long-term survivors (LTS) may provide important insight into the biology of GBM. We identified 7 patients with GBM treated at Memorial Sloan-Kettering Cancer Center (MSKCC) with survival greater than 48 months. We characterized the transcriptome of each patient and determined rates of MGMT promoter methylation and IDH1 and IDH2 mutational status. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5669

Platform:

GPL571

7 Samples

Download data: CEL

(Submitter supplied) Gene expression profiling revealed over-representation of a distinct (proneural-like) expression signature in long-term survivors that was linked to IDH1/2 mutation. However, among the IDH1/2-wildtype patients, tumors from long-term survivors did not show distinct gene expression profiles and included proneural, classical and mesenchymal glioblastoma subtypes. We performed genome- and/or transcriptome-wide molecular profiling of primary tumor samples from 70 glioblastoma patients of the German Glioma Network, including 23 longterm survivors with >36 months overall survival (OS), 16 short-term survivors with <12 months OS, and 31 patients with intermediate OS

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5205

Platform:

GPL570

70 Samples

Download data: CEL

Analysis of primary tumors from glioblastoma patients: long-term survivors with >36 months overall survival (OS), short-term survivors with <12 months OS, and patients with intermediate OS. Results provide insight into the molecular characterization of long-term survivors of glioblastoma.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 disease state sets

Platform:

GPL570

Series:

GSE53733

70 Samples

Download data: CEL

(Submitter supplied) MGMT promoter methylation status is currently the only established molecular prognosticator in IDH wild-type glioblastoma multiforme (GBM). Therefore, we aimed to discover novel therapy-associated epigenetic biomarkers. After enrichment for hypermethylated fractions using methyl-CpG-immunoprecipitation (MCIp), we performed global DNA methylation profiling for 14 long-term (LTS; >36 months) and 15 short-term (STS; 6–10 months) surviving GBM patients. more...

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL9767

29 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. BACKGROUND: Gliomas evade current therapies through primary and acquired resistance and the effect of temozolomide is mainly restricted to the subgroup of methylguanin-O6-methyltransferase promoter (MGMT) hypermethylated tumors. Further resistance markers and pathways against chemotherapy and radiotherapy are largely unknown and would help for better stratification. more...

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platforms:

GPL13534 GPL21145

315 Samples

Download data: IDAT

(Submitter supplied) The data contains Illumina 450k/EPIC array methylation files from 18 patients with diffuse IDH wild-type glioma from the Heidelberg Neuro-Oncology center

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platforms:

GPL21145 GPL13534

18 Samples

Download data: IDAT

(Submitter supplied) The data contains Illumina 450k/EPIC array methylation files from 298 glioblastoma patients from the EORTC 26101 study

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL13534

297 Samples

Download data: IDAT

(Submitter supplied) The data contains Illumina 450k/EPIC array methylation files from 380 glioblastoma patients of the Heidelberg Neuro-Oncology Center

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platforms:

GPL13534 GPL21145

380 Samples

Download data: CSV, IDAT

(Submitter supplied) The data contains Illumina 450k/EPIC array methylation files from 104 patients of the NOA-08 study comparing temozolomide alone vs. radiotherapy in elderly patients with glioblastoma

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platforms:

GPL21145 GPL13534

104 Samples

Download data: IDAT

(Submitter supplied) In this study, we aimed to characterize the global DNA methylation pattern of mainly IDH1 wild type survival outliers of glioblastoma.

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL13534

44 Samples

Download data: TXT

(Submitter supplied) IDH3a KO in NHAs was demonstrated to exert global DNA methylation changes. These studies were followed by an Illumina EPIC methylation array to evaluate the location of differentially methylated CpGs

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL21145

8 Samples

Download data: IDAT

(Submitter supplied) RNA-seq of NHAs with either wild-type IDH3a expression (control) or IDH3a KO via CRISPR/Cas9

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20301

8 Samples

Download data: TXT

(Submitter supplied) Background: Seizures can present at any time before or after the diagnosis of a glioma. Roughly, 25-30 % of glioblastoma (GBM) patients initially present with seizures, and an additional 30 % develop seizures during the course of the disease. Early studies failed to show an effect of general administration of anti-epileptic drugs for glioblastoma patients, since they were unable to stratify patients into high- or low- risk seizure groups. more...

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL21145

112 Samples

Download data: IDAT

(Submitter supplied) Young (8-12 weeks) and old (80-90 weeks) mice were engrafted with 50,000 murine GL261 cells. Extra-tumoral tissue was isolated on Day 21 post intracranial injection and sent for RNA sequencing analysis. Tissue from tumor naïve young and old mice was included as .controls

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21103

4 Samples

Download data: TXT