GEO DataSets

Analysis of mechanisms of prostate cancer resistance to antiandrogen therapy. Isogenic hormone-sensitive and drug-resistant hormone-refractory xenograft pairs examined.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 cell type sets

Platform:

GPL91

Series:

GSE847

14 Samples

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(Submitter supplied) Seven pairs of hormone sensitive and hormone refractory prostate cancer xenografts Keywords: parallel sample

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS535

Platform:

GPL91

14 Samples

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(Submitter supplied) AR overexpression converts antagonists to weak agonists Keywords: dose response

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS536

Platform:

GPL96

17 Samples

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Examination of antagonist to agonist conversion in androgen receptor-expressing hormone-sensitive LNCaP prostate cancer cells. Cells challenged with increasing doses of R1881, or bicalutamide.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 agent, 2 cell type, 7 dose sets

Platform:

GPL96

Series:

GSE846

17 Samples

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(Submitter supplied) In this study we performed transcriptional profiling of transurethral resections of hormone resistant prostate cancer and compared it with benign prostatic hyperplasia (BPH), untreated localized prostate cancer and hormone sensitive prostate cancer. Keywords: time course; disease state analysis

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL201

20 Samples

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(Submitter supplied) Following androgen ablation therapy (AAT), the vast majority of prostate cancer patients develop treatment resistance with a median time of 18-24 months to disease progression. To identify molecular targets that aid in prostate cancer cell survival and contribute to the androgen independent phenotype, we evaluated changes in LNCaP cell gene expression during 12 months of androgen deprivation. At time points reflecting critical growth and phenotypic changes, we performed Affymetrix expression array analysis to examine the effects of androgen deprivation during the acute response, during the period of apparent quiescence, and during the emergence of highly proliferative, androgen-independent prostate cancer cells (LNCaP-AI). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3358

Platform:

GPL570

16 Samples

Download data: CEL

Analysis of cultured LNCaP prostate cancer cells during 12 months of androgen deprivation. Following androgen ablation therapy, most prostate cancer patients develop treatment resistance. Results provide insight into prostate cancer cell survival and androgen-independence.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 growth protocol, 6 time sets

Platform:

GPL570

Series:

GSE8702

15 Samples

Download data: CEL