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Links from GEO DataSets

Items: 18

1.
Full record GDS5211

Turner syndrome: second trimester amniotic fluid

Analysis of second trimester amniotic fluid from Turner syndrome and euploid female fetuses. Turner syndrome is a sex chromosome aneuploidy generally due to monosomy X. Results provide insight into molecular mechanisms underlying Turner syndrome pathogenesis.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 disease state, 2 genotype/variation sets
Platform:
GPL570
Series:
GSE58435
10 Samples
Download data: CEL
2.

Amniotic fluid RNA gene expression profiling provides insights into the phenotype of Turner syndrome

(Submitter supplied) Background: Turner syndrome, a common sex chromosome aneuploidy, has characteristics and malformations associated with the phenotype. Fetal amniotic fluid is a complex biological material that could contribute to the understanding Turner syndrome pathogenesis. Global gene expression analysis of Turner syndrome fetal amniotic fluid supernatant was utilized to identify organ systems and specific genes that may play a role in the pathophysiologic changes that are seen in individuals with Turner syndrome. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5211
Platform:
GPL570
10 Samples
Download data: CEL
Series
Accession:
GSE58435
ID:
200058435
3.

Amniotic fluid transcriptomics reflects novel disease mechanisms in fetuses with myelomeningocele

(Submitter supplied) To identify molecular pathophysiologic changes and novel disease mechanisms specific to myelomeningocele by analyzing AFS cfRNA in fetuses with open myelomeningocele.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
20 Samples
Download data: CEL
Series
Accession:
GSE101141
ID:
200101141
4.

The amniotic fluid transcriptome: a source of novel information about human fetal development

(Submitter supplied) Amniotic fluid (AF) is a complex biological material that provides a unique window into the developing human. Residual AF supernatant contains cell-free fetal RNA. The objective of this study was to develop an understanding of the AF core transcriptome by identifying the transcripts ubiquitously present in the AF supernatant of euploid midtrimester fetuses. We detected 476 well-annotated genes present in all twelve AF samples. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
12 Samples
Download data: CEL
Series
Accession:
GSE33168
ID:
200033168
5.

RNA-Seq and expression microarray highlight different aspects of the fetal amniotic fluid transcriptome

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Expression profiling by high throughput sequencing
Platforms:
GPL570 GPL11154
10 Samples
Download data: CEL, FPKM_TRACKING
Series
Accession:
GSE49893
ID:
200049893
6.

RNA-Seq and expression microarray highlight different aspects of the fetal amniotic fluid transcriptome [microarray]

(Submitter supplied) The second trimester fetal transcriptome can be assessed based on cell-free RNA found within the amniotic fluid supernatant. The objective of this study was to compare the suitability of two technologies for profiling the human fetal transcriptome: RNA-Seq and expression microarray. Comparisons were based on total numbers of gene detected, rank-order gene expression, and functional genomic analysis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
5 Samples
Download data: CEL
Series
Accession:
GSE49891
ID:
200049891
7.

Comparative and integrated functional genomics analysis of Klinefelter and Turner syndromes reveals network-wide effects of the sex chromosome dosage changes

(Submitter supplied) Background: In both Turner syndrome (TS) and Klinefelter syndrome (KS) copy number aberrations of the X chromosome lead to various developmental symptoms. To date there has not been a comprehensive and directly comparative analysis of TS vs. KS regarding the changes on the molecular level Methods: We analyzed gene expression patterns with RNA-Seq and DNA methylation patterns with the CpGiant assay in lymphocytes, and chromatin conformation with in situ Hi-C in lymphoblastoid cell lines, from TS and KS patients together with their same gender controls. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Other
Platforms:
GPL16791 GPL18573 GPL20301
70 Samples
Download data: TSV, TXT
8.

Amniotic fluid transcriptome: a glimpse into fetal development and placental cellular dynamics during normal pregnancy

(Submitter supplied) Amniotic fluid was colelcted during midtrimester from 30 women and at term gestation from 68 women. Cell free RNA was profiled by HTA 2.0 arrays to study the effect of gestational age and other relevant convariates on gene expression and splicing during normal pregnancy.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17586
98 Samples
Download data: CEL
Series
Accession:
GSE133824
ID:
200133824
9.

Global gene expression analysis of amniotic fluid cell-free RNA from recipient twins with twin-twin transfusion syndrome

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
26 Samples
Download data: CEL
Series
Accession:
GSE47394
ID:
200047394
10.

Global gene expression analysis of amniotic fluid cell-free RNA from recipient twins with twin-twin transfusion syndrome [Set 2]

(Submitter supplied) To understand the biological pathways involved in twin-twin transfusion syndrome (TTTS) by performing global gene expression analysis of amniotic fluid (AF) cell-free RNA Analysis of paired data from TTTS cases and controls revealed differential expression of 801 genes, which were significantly enriched for neurological disease and cardiovascular system pathways. We also identified cardiovascular genes and pathways associated with the presence of critically abnormal Doppler measurements in Stage III TTTS recipients.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
10 Samples
Download data: CEL
Series
Accession:
GSE47393
ID:
200047393
11.

Global gene expression analysis of amniotic fluid cell-free RNA from recipient twins with twin-twin transfusion syndrome [Set 1]

(Submitter supplied) To understand the biological pathways involved in twin-twin transfusion syndrome (TTTS) by performing global gene expression analysis of amniotic fluid (AF) cell-free RNA Analysis of paired data from TTTS cases and controls revealed differential expression of 801 genes, which were significantly enriched for neurological disease and cardiovascular system pathways. We also identified cardiovascular genes and pathways associated with the presence of critically abnormal Doppler measurements in Stage III TTTS recipients.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
16 Samples
Download data: CEL
Series
Accession:
GSE47392
ID:
200047392
12.

Expression profiles of (40,XX) and (39,XO) females

(Submitter supplied) Gobal expression analysis in four somatic tissues (brain, liver, kidney and muscle) of adult 40,XX and 39,XO mice with the aim of identifying which genes are expressed from both X chromosomes as well as those genes deregulated in X chromosome monosomy. Keywords: Expression profiling by array
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3728
Platform:
GPL6105
36 Samples
Download data: TXT
Series
Accession:
GSE13520
ID:
200013520
13.
Full record GDS3728

X chromosome dosage model

Analysis of four somatic tissues (brain, liver, kidney and muscle) from 12-week-old 40,XX and X monosomic (39,XO) mice. In humans, complete or partial monosomy of the X chromosome results in Turner syndrome (45,XO). Genes deregulated in XO mice provide insight into the molecular basis of TS.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 genotype/variation, 4 tissue sets
Platform:
GPL6105
Series:
GSE13520
36 Samples
Download data
14.

Expression profiles of amniotic fluid from human fetuses with Down syndrome and euploid controls

(Submitter supplied) In order to characterize the differences between second trimester Down syndrome (DS) and euploid fetuses, we compared gene expression in uncultured amniotic fluid supernatant samples. We identified individually differentially expressed genes via paired t-tests in the matched samples, and a set of differentially expressed genes on chromosome 21 using Gene Set Enrichment Analysis. Functional pathway analysis of the resulting genes highlighted the importance of oxidative stress, ion transport, and G-protein signaling in the DS fetuses.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
14 Samples
Download data: CEL
Series
Accession:
GSE16176
ID:
200016176
15.

Global Gene Expression Analysis of Term Amniotic Fluid Cell-Free Fetal RNA

(Submitter supplied) The objective of this study was to identify the tissue expression patterns and biological pathways enriched in term amniotic fluid cell-free fetal RNA by comparing functional genomic analyses of term and second-trimester amniotic fluid supernatants. There were 2,871 significantly differentially regulated genes. In term amniotic fluid, tissue expression analysis showed enrichment of salivary gland, tracheal, and renal transcripts as compared with brain and embryonic neural cells in the second trimester. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
16 Samples
Download data: CEL
Series
Accession:
GSE46286
ID:
200046286
16.

Human germ cell formation in xenotransplants of induced pluripotent stem cells carrying X chromosome aneuploidies

(Submitter supplied) Induced pluripotent stem cells (iPSCs) offer opportunity for insight into the genetic requirements of the X chromosome for somatic and germline development. Turner syndrome is caused by complete or partial loss of the second sex chromosome; while more than 90% of Turner cases result in spontaneous fetal loss, survivors display an array of somatic and germline clinical characteristics. Here, we derived iPSCs from Turner syndrome and control individuals and examined germ cell development as a function of X chromosome composition. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
13 Samples
Download data: TXT
Series
Accession:
GSE55939
ID:
200055939
17.

The obese fetal transcriptome

(Submitter supplied) The objective of this study was to identify the tissue expression patterns and biological pathways enriched in term cord blood fetal RNA of obese women compared to lean In fetuses of obese women, 683 differentially regulated genes were identified.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
16 Samples
Download data: CEL
Series
Accession:
GSE60403
ID:
200060403
18.

Gene expression analysis of induced pluripotent stem cells from aneuploid chromosomal syndromes

(Submitter supplied) Background:Human aneuploidy is the leading cause of early pregnancy loss, mental retardation, and multiple congenital anomalies. Due to the high mortality associated with aneuploidy, the pathophysiological mechanisms of aneuploidy syndrome remain largely unknown. Previous studies focused mostly on whether dosage compensation occurs, and the next generation transcriptomics sequencing technology RNA-seq is expected to eventually uncover the mechanisms of gene expression regulation and the related pathological phenotypes in human aneuploidy. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL9442
6 Samples
Download data: TXT
Series
Accession:
GSE49247
ID:
200049247
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