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Links from GEO DataSets

Items: 20

1.
Full record GDS5172

Small-molecule inhibition of BRDT effect on testis

Analysis of testes from animals treated with JQ1, a small-molecule inhibitor of the testis-specific bromodomain-containing protein BRDT. BRDT is essential for spermatogenesis. Results provide insight into the molecular consequences of BRDT inhibition by JQ1.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL6887
Series:
GSE37894
6 Samples
Download data
2.

Testis Gene Expression Changes after JQ1 treatment

(Submitter supplied) JQ1 is a small-molecule (BET family) bromodomain inhibitor that causes a contraceptive effect in mice by blocking spermatogenesis and reducing sperm motility.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5172
Platform:
GPL6887
6 Samples
Download data: TXT
Series
Accession:
GSE37894
ID:
200037894
3.

JQ1 modulates inflammatory related-genes in human renal tubular epithelial cells

(Submitter supplied) Selective bromodomains inhibitors block the interaction between diverse bromodomains and extraterminal domains (BET) proteins and acetylated proteins. These inhibitors have shown beneficial effects in cancers malignancies and experimental inflammation in mouse models, but data on renal diseases are scarce. We have investigated the effect of the BET proteins inhibitor JQ1 in a mice model of unilateral ureteral obstruction. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
3 Samples
Download data: TXT
Series
Accession:
GSE71602
ID:
200071602
4.

BET Bromodomain Proteins Regulate Transcriptional Reprogramming in Genetic Dilated Cardiomyopathy

(Submitter supplied) In a model of chronic heart failure, BET bromodomain inhibition delayed cardiac remodeling and fibrosis by halting pathologic inflammatory gene networks in an NFkB-dependent manner.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
48 Samples
Download data: TXT
Series
Accession:
GSE152005
ID:
200152005
5.

Differential gene expression in neuroblastoma cells after treatment with vehicle control, JQ1, panobinostat, or combination of JQ1 and panobinostat

(Submitter supplied) The bromodomain inhibitor JQ1 and the histone deacetylase inhibitor panobinostat induce synergistic anticancer effects We analyzed whether JQ1 and panobinostat synergistically modulate gene expression
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16686
12 Samples
Download data: CEL
Series
Accession:
GSE68690
ID:
200068690
6.

Therapeutic Targeting of BET Bromodomain Proteins in Castration-Resistant Prostate Cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL4133 GPL15433
83 Samples
Download data: BW, TXT
Series
Accession:
GSE55064
ID:
200055064
7.

Therapeutic Targeting of BET Bromodomain Proteins in Castration-Resistant Prostate Cancer (microarray)

(Submitter supplied) Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably succumb to the disease. The development and progression to CRPC following androgen ablation therapy is predominantly driven by unregulated androgen receptor (AR) signaling1-3. Despite the success of recently approved therapies targeting AR signaling such as abiraterone4-6 and second generation anti-androgens MDV3100 (enzalutamide)7,8, durable responses are limited, presumably due to acquired resistance. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
48 Samples
Download data: TXT
Series
Accession:
GSE55063
ID:
200055063
8.

Therapeutic Targeting of BET Bromodomain Proteins in Castration-Resistant Prostate Cancer (ChIP-Seq)

(Submitter supplied) Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably succumb to the disease. The development and progression to CRPC following androgen ablation therapy is predominantly driven by unregulated androgen receptor (AR) signaling1-3. Despite the success of recently approved therapies targeting AR signaling such as abiraterone4-6 and second generation anti-androgens MDV3100 (enzalutamide)7,8, durable responses are limited, presumably due to acquired resistance. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL15433
35 Samples
Download data: BW
Series
Accession:
GSE55062
ID:
200055062
9.

ChIP-Seq and CAGE profiling of cell lines

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
64 Samples
Download data: BED, BROADPEAK, NARROWPEAK
Series
Accession:
GSE113715
ID:
200113715
10.

ChIP-Seq of H4K5acK8ac and BRD2 in H23 NSCLC cell line treated with 500 nM JQ1 for 24h

(Submitter supplied) Changes in acetylation of histone H4 are a common hallmark of cancer cells. In leukemia cells, histone H4 is characterized by loss of K16 mono-acetylation. Bromodomain proteins specifically recognize acetylated lysines and have been used as a target for anti cancer drug, JQ1 and iBET. Although acetylation and de-acetylation of histone H4 have been shown to have big impact in cancer cells, little attention has been focused on histone H4-acetylation at a genome level. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
8 Samples
Download data: BED, BROADPEAK
Series
Accession:
GSE113714
ID:
200113714
11.

CAGE profiling after treatment with JQ1 BET inhibitor in lung cancer cell line.

(Submitter supplied) The bromodomain and extra-terminal domain (BET) proteins are promising drug targets for cancer and immune diseases. However, BET inhibition effects have been studied more in the context of bromodomain-containing protein 4 (BRD4) than BRD2, and the BET protein association to histone H4-hyperacetylated chromatin is not understood at the genome-wide level. Here, we report transcription start site (TSS)-resolution integrative analyses of ChIP-seq and transcriptome profiles in human non-small cell lung cancer (NSCLC) cell line H23. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
27 Samples
Download data: BED, TXT
12.

ChIP-Seq of H4K5acK8ac in GM12878, K562

(Submitter supplied) From: "JQ1 affects BRD2-dependent and independent transcription regulation without disrupting H4-hyperacetylated chromatin states". The bromodomain and extra-terminal domain (BET) proteins are known as drug targets in diseases. However, the BET protein association profile to histone H4 hyperacetylation is not well understood and BET inhibition effects have been studied more in the context of BRD4 than BRD2. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
6 Samples
Download data: NARROWPEAK
Series
Accession:
GSE113635
ID:
200113635
13.

ChIP-Seq of H4K5acK8ac, H3K27ac, H3K4me1, H3K4me3, H3K36me3, H3K9me3, H3K27me3 and BRD2 in H23 NSCLC cell line

(Submitter supplied) The bromodomain and extra-terminal domain (BET) proteins are known as drug targets in diseases. However, the BET protein association profile to histone H4 hyperacetylation is not well understood and BET inhibition effects have been studied more in the context of BRD4 than BRD2. Here, by integrating chromatin and transcriptome analyses of ChIP-seq and Cap Analysis Gene Expression (CAGE) datasets, we show that di-acetylation at K5 and K8 of histone H4 (H4K5acK8ac) co-localizes with H3K27ac and BRD2 in the majority of active enhancers and promoters, where BRD2 has a stronger association with H4K5acK8ac than H3K27ac. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
23 Samples
Download data: NARROWPEAK
Series
Accession:
GSE104481
ID:
200104481
14.

Syngergistic Effect of JQ1 and Rapamycin for Treatment of Human Osteosarcoma

(Submitter supplied) Bromodomain and extra terminal domain (BET) proteins are important epigenetic regulators facilitating the transcription of genes in chromatin areas linked to acetylated histones. JQ1, a BET protein inhibitor, has antiproliferative activity against many cancers, mainly through inhibition of c-MYC and upregulation of p21. In this research, we investigated the use of JQ1 for human osteosarcoma (OS) treatment. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
8 Samples
Download data: TXT
Series
Accession:
GSE57203
ID:
200057203
15.

JQ1 prevents BRD4 recruitment to the lytic origins of replication [Akata-Zta Brd4 ChIP-seq]

(Submitter supplied) Lytic infection by the Epstein-Barr virus (EBV) poses numerous health risks, such as infectious mononucleosis and lymphoproliferative disorder. We demonstrate that JQ1 and other BET inhibitors block two different steps in the sequential cascade of the EBV life cycle: expression of the immediate-early gene BZLF1 and lytic genome replication. This represents a novel mode of action for antiviral drugs that may increase efficacy and decrease emergence of resistance. more...
Organism:
human gammaherpesvirus 4; Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL23362
8 Samples
Download data: WIG
Series
Accession:
GSE98773
ID:
200098773
16.

JQ1 prevents BRD4 recruitment to the lytic origins of replication [Akata-Zta DNA-seq]

(Submitter supplied) Lytic infection by the Epstein-Barr virus (EBV) poses numerous health risks, such as infectious mononucleosis and lymphoproliferative disorder. We demonstrate that JQ1 and other BET inhibitors block two different steps in the sequential cascade of the EBV life cycle: expression of the immediate-early gene BZLF1 and lytic genome replication. This represents a novel mode of action for antiviral drugs that may increase efficacy and decrease emergence of resistance. more...
Organism:
human gammaherpesvirus 4; Homo sapiens
Type:
Other
Platform:
GPL23362
8 Samples
Download data: WIG
Series
Accession:
GSE98772
ID:
200098772
17.

BET inhibitors block the Epstein-Barr virus lytic cycle at two distinct steps

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
human gammaherpesvirus 4; Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
Platforms:
GPL23362 GPL22131 GPL22132
106 Samples
Download data: WIG
Series
Accession:
GSE84214
ID:
200084214
18.

BET proteins bind the lytic origins of replication [MutuI ChIP-seq]

(Submitter supplied) Lytic infection by the Epstein-Barr virus (EBV) poses numerous health risks, such as infectious mononucleosis and lymphoproliferative disorder. We demonstrate that JQ1 and other BET inhibitors block two different steps in the sequential cascade of the EBV life cycle: expression of the immediate-early gene BZLF1 and lytic genome replication. This represents a novel mode of action for antiviral drugs that may increase efficacy and decrease emergence of resistance. more...
Organism:
Homo sapiens; human gammaherpesvirus 4
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL23362 GPL22131 GPL22132
18 Samples
Download data: WIG
Series
Accession:
GSE84213
ID:
200084213
19.

BET inhibitors suppress lytic DNA replication [Akata-Zta DNA-seq]

(Submitter supplied) Lytic infection by the Epstein-Barr virus (EBV) poses numerous health risks, such as infectious mononucleosis and lymphoproliferative disorder. We demonstrate that JQ1 and other BET inhibitors block two different steps in the sequential cascade of the EBV life cycle: expression of the immediate-early gene BZLF1 and lytic genome replication. This represents a novel mode of action for antiviral drugs that may increase efficacy and decrease emergence of resistance. more...
Organism:
Homo sapiens; human gammaherpesvirus 4
Type:
Other
Platform:
GPL22132
30 Samples
Download data: XLSX
Series
Accession:
GSE84212
ID:
200084212
20.

BET inhibitors suppress lytic DNA replication [Akata-Zta RNA-seq]

(Submitter supplied) Lytic infection by the Epstein-Barr virus (EBV) poses numerous health risks, such as infectious mononucleosis and lymphoproliferative disorder. We demonstrate that JQ1 and other BET inhibitors block two different steps in the sequential cascade of the EBV life cycle: expression of the immediate-early gene BZLF1 and lytic genome replication. This represents a novel mode of action for antiviral drugs that may increase efficacy and decrease emergence of resistance. more...
Organism:
human gammaherpesvirus 4; Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL22132
18 Samples
Download data: WIG
Series
Accession:
GSE84211
ID:
200084211
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