GEO DataSets

Analysis of quadriceps from a muscle-specific, Diabetes and Obesity Regulated gene (DOR; also named Tp53inp2) overexpression line (SKM-Tg). DOR gain of function causes a reduction in muscle mass. Results provide insight into the functional role of DOR in skeletal muscle.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL11180

Series:

GSE54917

7 Samples

Download data: CEL

(Submitter supplied) We analyzed the functional role of DOR (Diabetes and Obesity Regulated gene) (also named Tp53inp2) in skeletal muscle. We show that DOR has a direct impact on skeletal muscle mass in vivo. Thus, using different transgenic mouse models, we demonstrate that while muscle-specific DOR gain-of-function results in reduced muscle mass, loss-of-function causes muscle hypertrophy. DOR has been described as a protein with two different functions, i.e., a nuclear coactivator and an autophagy regulator (Baumgartner et. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS5053 GDS5054

Platform:

GPL11180

13 Samples

Download data: CEL

Analysis of quadriceps from a muscle-specific, Diabetes and Obesity Regulated gene (DOR; Tp53inp2) knockout line (SKM-KO). Deletion of DOR results in muscle hypertrophy. Results provide insight into the functional role of DOR in skeletal muscle.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL11180

Series:

GSE54917

6 Samples

Download data: CEL

(Submitter supplied) In skeletal muscle, the pattern of electrical activity regulates the expression of proteins involved in synaptic transmission, contraction and metabolism. Disruptions in electrical activity, resulting from prolonged bed-rest, cast-immobilization or trauma, inevitably lead to muscle atrophy. The mechanisms that regulate muscle atrophy are poorly understood, but it seems likely that changes in gene expression play a key role in initiating and maintaining a muscle atrophy program. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

11 Samples

Download data: CEL

(Submitter supplied) Loss of muscle proteins and the consequent weakness has important clinical consequences in diseases such as cancer, diabetes, chronic heart failure and in ageing. In fact, excessive proteolysis causes cachexia, accelerates disease progression and worsens life expectancy. Muscle atrophy involves a common pattern of transcriptional changes in a small subset of genes named atrophy-related genes or atrogenes. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10688

18 Samples

Download data: CSV

(Submitter supplied) Loss of muscle proteins and the consequent weakness has important clinical consequences in diseases such as cancer, diabetes, chronic heart failure and in ageing. In fact, excessive proteolysis causes cachexia, accelerates disease progression and worsens life expectancy. Muscle atrophy involves a common pattern of transcriptional changes in a small subset of genes named atrophy-related genes or atrogenes. more...

Organism:

Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL17835

39 Samples

Download data: CSV