Similar studies for GEO DataSets (Select 4991) - GEO DataSets

Select item 49911.

Glyoxalase 1 overexpression effect on the brain

Analysis of brains from C57BL/6J transgenics overexpressing glyoxalase 1 (Glo1). Glo1 is a cytosolic enzyme that catabolizes acyclic alpha-oxoaldehydes, particularly methylglyoxal. Results provide insight into the effect of Glo1 on anxiety-like behavior.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:: GPL6246
Series:: GSE36819
10 Samples

Download data: CEL

DataSet

Accession:: GDS4991

ID:: 4991

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000368192.

Expression data from BAC transgenic mice overexpressing Glo1

(Submitter supplied) We generated mice with a transgenic BAC on a B6 background. The BAC contains Glo1, and the transgenic mice were found to overexpress Glo1. We performed a microarray on whole-brain RNA of adult mice to identify differentially expressed genes resulting from Glo1 overexpression.

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4991
Platform:: GPL6246
10 Samples

Download data: CEL

Series

Accession:: GSE36819

ID:: 200036819

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000797373.

A Glo1-methylglyoxal pathway that is perturbed in maternal diabetes regulates embryonic and adult neural stem cell pools in offspring

(Submitter supplied) We used microarrays to compare the gene expression profile in cultured primary neurospheres derived from the subventricular zone of adult (2 m.o.) offspring of mothers treated with PBS or methylglyoxal during pregnancy

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
6 Samples

Download data: CEL

Series

Accession:: GSE79737

ID:: 200079737

Select item 2000033274.

Adult mouse gene expression

(Submitter supplied) Adult mouse gene expression patterns in common strains Keywords: mouse strain and brain region comparison

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS1406
Platform:: GPL81
87 Samples

Download data: CEL, EXP

Series

Accession:: GSE3327

ID:: 200003327

Select item 14065.

Brain regions of various inbred strains

Analysis of 7 brain regions of 6 inbred strains. 7 week old males from 129S6/SvEvTac, A/J, C3H/HeJ, C57BL/6J, DBA/2J, and FVB/NJ strains examined. Results correlated with behavioral phenotypes and identify candidate genes for anxiety-like behavior.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 6 strain, 7 tissue sets

Platform:: GPL81
Series:: GSE3327
87 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS1406

ID:: 1406

Select item 2001495856.

Impairment of methylglyoxal detoxification systems causes mitochondrial dysfunction and behavioral deficits

(Submitter supplied) Methylglyoxal (MG) is a reactive alpha-dicarbonyl by-product of glycolysis. Several bio-defense systems to detoxify the highly toxic MG are equipped in our body, including an enzymatic system by glyoxalase (GLO) 1 and GLO2 and a scavenge system by vitamin B6 (VB6). We have reported that some population of patients with schizophrenia shows impairment of the MG detoxification systems. Although we have evidences showing a link between impairment of MG detoxification systems and development of schizophrenia, the molecular mechanism to connect them remains poorly understood. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
60 Samples

Download data: TXT

Series

Accession:: GSE149585

ID:: 200149585

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000195347.

Alpha-synuclein deficiency affects brain Foxp1 expression and ultrasonic vocalization

(Submitter supplied) Alpha-synuclein is an abundant protein implicated in synaptic function and plasticity, but the molecular mechanism of its action is not understood. Missense mutations and gene duplication/triplication events result in Parkinson's disease, a neurodegenerative disorder of old age with impaired movement and emotion control. Here, we systematically investigated the striatal as well as the cerebellar transcriptome profile of alpha-synuclein-deficient mice via a genome-wide microarray survey in order to gain hypothesis-free molecular insights into the physiological function of alpha-synuclein. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4153
Platform:: GPL1261
26 Samples

Download data: CEL

Series

Accession:: GSE19534

ID:: 200019534

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 41538.

Alpha-synuclein deficiency effect on striatum and cerebellum: time course

Analysis of striatum and cerebellum from alpha-synuclein (SNCA) knockouts at 6 or 21 months of age. SNCA mutations result in impaired movement and depression/anxiety, manifesting in humans as Parkinson's disease (PD). Results provide molecular insights into physiological role of alpha-synuclein.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 genotype/variation, 2 time, 2 tissue sets

Platform:: GPL1261
Series:: GSE19534
26 Samples

Download data: CEL

DataSet

Accession:: GDS4153

ID:: 4153

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

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