GEO DataSets

Analysis of central nervous system primitive neuroectodermal tumors (CNS PNET). CNS PNETs are embryonal tumors that occur predominantly in children. Results provide insight into the molecular mechanisms underlying CNS PNET pathogenesis.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 5 disease state sets

Platform:

GPL570

Series:

GSE19404

24 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL6947 GPL8179

137 Samples

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(Submitter supplied) In this study, we screened a cohort of 57 paediatric brain tumours, with a wide range of pathologies to identify gene expression profiles

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

73 Samples

Download data: TXT

(Submitter supplied) Murine and human genome-wide microarray expression profiles (including GSE19404) were compared using Partek and Gene Set Enrichment Analysis (GSEA) in order to identify similarities. A murine PNET-like tumour by morphology was found to resemble human ATRT, whereas experimental glioma resembled a particular human glioblastoma subclass.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6096

33 Samples

Download data: CEL

(Submitter supplied) Central nervous system primitive neuroectodermal tumors (CNS PNET) and medulloblastomas are both embryonal tumors that predominantly occur in children. We used microarrays to analyse a cohort of CNS PNETs and medulloblastomas to identify gene expression related to tumor subgroups.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4838

Platform:

GPL570

24 Samples

Download data: CEL

(Submitter supplied) sPNETs are highly malignant embryonal brain tumours of poor prognosis. The underlying biology is poorly understood. To address this we therefore performed high resolution genetic analysis. 36 CNS PNETs and 8 PBs were analysed using the Affymetrix 100K and 500K Mapping Set to identify copy number imbalance at both the chromosome and gene level. Keywords: Affymetrix 100K SNP array, Affymetrix 500K SNP arrays

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array; SNP genotyping by SNP array

4 related Platforms

108 Samples

Download data: CEL, CHP

(Submitter supplied) Glioblastoma (GBM) is a highly lethal brain tumor presenting as one of two subtypes with distinct clinical histories and molecular profiles. The primary GBM subtype presents acutely as high-grade disease that typically harbors EGFR, PTEN and Ink4a/Arf mutations, and the secondary GBM subtype evolves from the slow progression of low-grade disease that classically possesses PDGF and p53 events1. Here, we show that concomitant CNS-specific deletion of p53 and Pten in the mouse CNS generates a penetrant acute-onset high-grade malignant glioma phenotype with striking clinical, pathological and molecular resemblance to primary GBM in humans. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

5 Samples

Download data: CEL

(Submitter supplied) To investigate differences in gene expression after overexpression miR-218 in U251MG

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL14550

2 Samples

Download data: TXT

(Submitter supplied) We have generated DNA methylation profiles for 31 human CNS tumors that represent our cohort of ET, PLAGL tumors

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platforms:

GPL13534 GPL21145

31 Samples

Download data: IDAT

(Submitter supplied) Novel prognostic subclasses of high-grade astrocytoma are identified and discovered to resemble stages in neurogenesis. One tumor class displaying neuronal lineage markers shows longer survival, while two tumor classes enriched for neural stem cell markers display equally short survival. Poor prognosis subclasses exhibit either markers of proliferation or of angiogenesis and mesenchyme. Analysis of gene expression data is described in Phillips et al., Cancer Cell, 2006. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS1815 GDS1816

Platforms:

GPL96 GPL97

200 Samples

Download data: CEL, EXP

Analysis of high-grade glioma (HGGs) samples from cases of WHO grade III and IV astrocytomas. Results classify HGGs into molecular subclasses with prognostic value that predict survival and disease progression. The molecular subclasses resemble key stages of neurogenesis.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 cell type, 4 disease state, 6 other, 2 specimen sets

Platform:

GPL97

Series:

GSE4271

100 Samples

Download data: CEL, EXP

Analysis of high-grade glioma (HGGs) samples from cases of WHO grade III and IV astrocytomas. Results classify HGGs into molecular subclasses with prognostic value that predict survival and disease progression. The molecular subclasses resemble key stages of neurogenesis.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 cell type, 4 disease state, 6 other, 2 specimen sets

Platform:

GPL96

Series:

GSE4271

100 Samples

Download data: CEL, EXP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL8179 GPL6884

108 Samples

Download data

(Submitter supplied) MicroRNA has a great potential in predicting survival of cancer patient. We used a genome-wide microRNA expression profiling to identify a miRNA signature for the prediction of clinical outcome of primary GBM patients.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL8179

87 Samples

Download data: TXT

(Submitter supplied) We used a genome-wide coding gene expression profiling to identify a gene signature for the molecular classification or prognostic prediction of primary GBMs.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6884

21 Samples

Download data: TXT

(Submitter supplied) To understand the diversity of expression states within IDH-mutant astrocytoma tumors, we profiled 6341 cells from 10 tumors by single cell RNA-seq

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18573

6341 Samples

Download data: TXT

(Submitter supplied) Trangenic mice with brain-targeted deletion of one allele of p53 and one allele ot Pten were irradiated with particulate radiation. Radiation induced gliomas were analyzed to identify copy number variations

Organism:

Mus musculus

Type:

Genome variation profiling by array

Platform:

GPL21714

7 Samples

Download data: TXT

(Submitter supplied) To find different gene expression signature in OVCAR5 cells with PTPRR -WT expression or PTPRR-DA expression compared with control cells, we did RNA-seq analyses.To find different gene expression signature in xenagraft tumors generated from OVCAR5 cells with PTPRR -WT expression or PTPRR-DA expression compared with control cells, we did RNA-seq analyses.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20795

15 Samples

Download data: TXT

(Submitter supplied) V600E being the most common mutation in BRAF, leads to constitutive activation of the MAPK signaling pathway. The majority of V600E BRAF positive melanoma patients treated with the BRAF inhibitor vemurafenib showed initial good clinical responses but relapsed due to acquired resistance to the drug. The aim of the present study was to identify possible biomarkers associated with the emergence of drug resistant melanoma cells. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17586

6 Samples

Download data: CEL

(Submitter supplied) Context dependent molecular cues shape the formation of the cerebral vascular network and the function of the blood-brain barrier (BBB). The Wnt/ß-catenin pathway is orchestrating CNS vascular development, but downstream mediators have not been characterized. Here we generated an endothelial cell-specific R26-Axin1 overexpression (AOE) mouse model to inhibit Wnt/ß-catenin signaling. In AOE mice we discovered that blockade of Wnt/ß-catenin pathway leads to premature regression and remodeling without compromising BBB integrity. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

6 Samples

Download data: TXT