GEO DataSets

Analysis of liver, heart, kidney and skeletal muscle from animals treated with different doses (therapeutic, toxic) of PPM-201, a pan-peroxisome proliferator-activated receptor (pan-PPAR) agonist. Results provide insight into molecular bases of organ-specific toxicity induced by a panPPAR agonist.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 3 dose, 4 tissue sets

Platform:

GPL1261

Series:

GSE31561

36 Samples

Download data: CEL

(Submitter supplied) In this study, we aim to identify candidate biomarkers which may be useful as surrogate indicators of toxicity for pre-clinical development of panPPAR-agonist drug candidates. Gene expression microarray, histopathology and clinical chemistry data were generated from liver, heart, kidney and skeletal muscles of three groups of mice administered with three different dosages of an experimental pan-peroxisome proliferator-activated receptor (pan-PPAR) agonist, PPM-201, for 14 days. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4806

Platform:

GPL1261

36 Samples

Download data: CEL

(Submitter supplied) 3T3-L1 cells treated 24 hours with either 0.1% DMSO, 20uM pioglitazone, 1uM rosiglitazone or 20uM troglitazone Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS734

Platform:

GPL81

11 Samples

Download data

Expression profiling of 3T3-L1 adipocytes treated with the thiazolidinediones (TZD) pioglitazone, rosiglitazone, and troglitazone, at 20 uM, 1 uM, and 20 uM respectively. TZDs increase sensitivity of cells to insulin in patients with type II diabetes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 agent sets

Platform:

GPL81

Series:

GSE1458

11 Samples

Download data

(Submitter supplied) Characterization of Peroxisome Proliferator-Activated Receptor alpha (PPAR(alpha)) - Independent Effects of PPAR(alpha) Activators in the Rodent Liver: Di-(2-ethylhexyl) phthalate Activates the Constitutive Activated Receptor data files in this series indicate the involvement of PPAR(alpha) and CAR regulatory pathway after DEHP treatment. Keywords: gene expression/microarray

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3748

Platform:

GPL6246

15 Samples

Download data: CEL

Analysis of livers from peroxisome proliferator-activated receptor (PPAR) α-null animals exposed to the plasticizer di-(2-ethylhexyl) phthalate (DEHP). DEHP increases liver tumors in the absence of PPARα. Results provide insight into DEHP-induced transcriptional changes independent of PPARα.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 genotype/variation sets

Platform:

GPL6246

Series:

GSE18564

15 Samples

Download data: CEL

(Submitter supplied) Dendritic cells (DCs) are a complex group of cells which play a critical role in vertebrate immunity. Spleen or lymph node resident DCs are subdivided into conventional DC (cDC) subsets (CD11b and CD8alpha in mouse; BDCA1 and BDCA3 in man) and plasmacytoid DCs (pDCs). It is currently unclear if these various DC populations belong to a unique hematopoietic lineage and if the subsets identified in the mouse and human systems are evolutionary homologs. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

13 Samples

Download data: CEL, CHP, EXP

(Submitter supplied) The objective of the present study is to examine the potential role of the pregnane x receptor (PXR) in mice treated with an small molecule inhibitor for beta-secretase (CMP013)

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

20 Samples

Download data: CEL