Similar studies for GEO DataSets (Select 4765) - GEO DataSets

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Items: 3

Select item 47651.

Breast adenocarcinoma MCF-7 cell line response to 27-Hydroxycholesterol and estradiol

Analysis of MCF-7 cells treated with 27HC in the presence of E2. 27HC, a primary metabolite of cholesterol and an estrogen receptor (ER) ligand, increases ER-dependent growth in mouse models of breast cancer. Results provide insight into a relationship between hypercholesterolemia and breast cancer.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 4 agent sets

Platform:: GPL570
Series:: GSE46924
12 Samples

Download data: CEL

DataSet

Accession:: GDS4765

ID:: 4765

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000469242.

27-Hydroxycholesterol links cholesterol and breast cancer pathophysiology.

(Submitter supplied) The cholesterol metabolite and SERM, 27HC, is the signaling molecule that links cholesterol to breast cancer pathophysiology Hypercholesterolemia is a risk factor for breast cancer, and patients taking statins demonstrate lower breast cancer incidence and decreased breast cancer recurrence, data that highlights the potential importance of the recent finding that 27-Hydroxycholesterol (27HC), a primary metabolite of cholesterol, acts as a selective estrogen receptor modulator (SERM). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4765
Platform:: GPL570
12 Samples

Download data: CEL

Series

Accession:: GSE46924

ID:: 200046924

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001719493.

The cholesterol metabolite 27-hydroxycholesterol increases the secretion of extracellular vesicles which promote breast cancer progression

(Submitter supplied) Mice bearing Met1 tumors were treated with extracellular vessicles (EVs) isolated from neutrophils treated with vehicle (DMSO) or 27-hydroxycholesterol. RNAseq was performed on harvested tumors.