GEO DataSets

Analysis of LN229 glioma cells with doxycycline-inducible expression of Cyr61 (CCN1), induced for 24h with doxycycline. CCN1 expression may reduce efficacy of oncolytic HSV-1 brain cancer therapy. Results provide insight into CCN1-mediated oncolytic HSV-1 inhibition.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 protocol sets

Platform:

GPL570

Series:

GSE29384

6 Samples

Download data: CEL

(Submitter supplied) Glioblastoma multiforme is the most common and aggressive form of brain cancer. The use of oncolytic HSV-1 (oHSV) to selectively target brain cancer cells leading to their lytic destruction has shown to be very promising in a preclinical setting, but is lacking efficacy in clinical trials. Cyr61, a secreted extracellular matrix protein which functions to promote angiogenesis, migration, proliferation and tumorigenesis, was found to be upregulated rapidly following oHSV infection. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4475

Platform:

GPL570

6 Samples

Download data: CEL

(Submitter supplied) Effects of the matricellular protein CCN1 on macrophage inflammatory gene expression was tested in a macrophage cell line I-13.35. CCN1 (CYR61) is a matricellular protein that is highly expressed at sites of inflammation and wound repair. In these contexts, CCN1 can modify the activities of specific cytokines, enabling TNF-alpha to be cytotoxic without blocking NFkB activity and enhancing the apoptotic activity of FasL and TRAIL. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL9853

2 Samples

Download data: TXT