GEO DataSets

Analysis of brain tumor tissue from primary central nervous system lymphoma (PCNSL) patients. PCNSL is an extranodal form of non-Hodgkin lymphoma that arises in the craniospinal axis. Results provide insight into the molecular mechanisms underlying survival in patients with PCNSL.

Organism:

Homo sapiens

Type:

Expression profiling by array, log2 ratio, 21 age, 3 agent, 2 gender, 7 other, 4 time sets

Platform:

GPL570

Series:

GSE34771

34 Samples

Download data: CEL

(Submitter supplied) This study aimed to define the genes associated with PCNSL patient survival. Expression profiling was performed on 34 PCNSLs. A gene classifier was developed.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4464

Platform:

GPL570

34 Samples

Download data: CEL

(Submitter supplied) Medullary breast cancers (MBC) display a basal profile, but a favorable prognosis. We hypothesized that a previously published 368-gene expression signature associated with MBC might serve to define a prognostic classifier in basal cancers. We collected public gene expression and histoclinical data of 2145 invasive early breast adenocarcinomas. We developed a Support Vector Machine (SVM) classifier based on this 368-gene list in a learning set, and tested its predictive performances in an independent validation set. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

266 Samples

Download data: CEL

(Submitter supplied) This series is part of a larger series (GSE24549) of colorectal cancer tissue samples analyzed for global gene expression. The expression measures were used to develope a gene signature for prediction of prognosis in stage II and III colorectal cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

95 Samples

Download data: CEL, CHP

(Submitter supplied) By the use of whole genome transcription analysis, we aimed to develop a gene expression classifier to increase the likelihood of identifying stage II colorectal cancer (CRC) samples with a poor prognostic outcome. Gene expression measurement were measured by the GeneChip® Human Exon 1.0 ST Arrays from Affymetrix.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

50 Samples

Download data: CEL, CHP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL5175 GPL11028

333 Samples

Download data: CEL, CHP

(Submitter supplied) Colorectal cancer is a heterogeneous disease molecularly characterized by inherent genomic instabilities, chromosome instability and microsatellite instability. In the present study we propose transcriptome instability as an analogue to genomic instability on the transcriptome level. Exon microarray data from two independent series of altoghether 160 colorectal cancer tissue samples was used for global alternative splicing detection using the FIRMA algorithm (aroma.affymetrix). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL11028 GPL5175

167 Samples

Download data: CEL, CHP

(Submitter supplied) Colorectal cancer is a heterogeneous disease molecularly characterized by inherent genomic instabilities, chromosome instability and microsatellite instability. In the present study we propose transcriptome instability as an analogue to genomic instability on the transcriptome level. Exon microarray data from two independent series of altoghether 160 colorectal cancer tissue samples was used for global alternative splicing detection using the FIRMA algorithm (aroma.affymetrix). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL5175 GPL11028

166 Samples

Download data: CEL, CHP

(Submitter supplied) Expression profiling of miRNA was performed on 20 PCNSLs. A gene classifier was developed.

Organism:

Homo sapiens; synthetic construct

Type:

Non-coding RNA profiling by array

Platform:

GPL19117

20 Samples

Download data: CEL

(Submitter supplied) Mean age of patients was 53.2 years old (range, 18–80). Twenty-two patients were males, and 7 were females. Tissues were snap-frozen in liquid nitrogen within 5 min of harvesting, and stored thereafter at －80℃. Samples were specifically re-reviewed by a board-certified pathologist in our institution, using observation of sections of paraffin-embedded tissues that were adjacent or in close proximity to the frozen sample from which the RNA was extracted. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL876

29 Samples

Download data

(Submitter supplied) Advanced-stage ovarian cancer is one of the most lethal gynecologic malignancies. To improve prognosis of patients with ovarian cancers, a predictive biomarkers leading to personalized treatments are required. In this large-scale cross-platform study of six microarray datasets consisting of 1054 ovarian cancer patients, we developed a novel risk classification system based on a 126-gene expression signature for predicting overall survival by applying elastic net7 and 10-fold cross validation to a Japanese dataset A (n = 260). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6480

40 Samples

Download data: TXT

(Submitter supplied) The Japanese Serous Ovarian Cancer Study Group Advanced-stage ovarian cancer is one of the most lethal gynecologic malignancies. To improve prognosis of patients with ovarian cancers, a predictive biomarkers leading to personalized treatments are required. In this large-scale cross-platform study of six microarray datasets consisting of 1054 ovarian cancer patients, we developed a novel risk classification system based on a 126-gene expression signature for predicting overall survival by applying elastic net7 and 10-fold cross validation to a Japanese dataset A (n = 260). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL570 GPL6480

270 Samples

Download data: CEL, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Genome variation profiling by genome tiling array

Platforms:

GPL6480 GPL8841

39 Samples

Download data: TXT

(Submitter supplied) Genomic aberrations in primary central nervous system lymphoma (PCNSL).

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platform:

GPL8841

25 Samples

Download data: TXT

(Submitter supplied) A genome-wide gene expression comparison between primary central nervous system lymphoma (PCNSL) and normal lymph node was performed to identify a differential exprssion and specific pathway.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6480

14 Samples

Download data: TXT

(Submitter supplied) This series represents expression profiles of 34 non-seminoma germ cell tumors (NSGCTs) from patients who received cisplatin based chemotherarpy for treatment of their disease for whom full clinical follow-up information was available. These specimens were used as a validation set to test outcome prediction models using a subset of previously profiled GCT specimens (see GEO accession #GSE3218). Keywords: Disease state analysis (good vs. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL97 GPL96

68 Samples

Download data: CEL, EXP

(Submitter supplied) We used microarrays to select the genes associated glioma patients survival. This study aimed to define genes associated with survival. Expression profiling was performed on 50 gliomas. A gene classifier was developed.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

50 Samples

Download data: CEL