GEO DataSets

Analysis of mononuclear cells from PICALM-MLLT10-positive T-cell acute lymphoblastic leukemia (T-ALL) patients (2 cases with histone methyltransferase gene EZH2 mutations) and PICALM-MLLT10-negative T-ALL patients. Results provide insight into molecular mechanisms underlying the leukemia subtypes.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 5 disease state, 2 genotype/variation sets

Platform:

GPL570

Series:

GSE30599

29 Samples

Download data: CEL

(Submitter supplied) Interest focuses on genes encoding histone demethylases in hematologic malignancies, such as EZH2 (enhancer of zeste homolog 2). EZH2 mutations were recurrently observed in lymphomas and chronic myeloid malignancies, but data in acute leukemias are limited. We investigated 13 PICALM-MLLT10 (=CALM-AF10) rearranged acute leukemia predominantly of T-lineage (7 m/6 f; 6–53 years) by deep-sequencing for EZH2mut and identified 3 (23%) EZH2mut carriers: one splice site mutation in exon 14, while two patients had missense mutations in the D1 region of exon 5 which interacts with different DNA methyltransferase genes (but no DNMT3Amut was detected in the 13 PICALM-MLLT10-positive patients). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4300

Platform:

GPL570

29 Samples

Download data: CEL

(Submitter supplied) Follicular lymphoma (FL) is an indolent, but incurable subtype of non-Hodgkin lymphoma. These tumor harbor t (14;18) translocation in at least 90% of patients. Recently, activating EZH2 mutations have been Follicular lymphoma (FL) is an indolent, but incurable subtype of non-Hodgkin lymphoma. These tumor harbor t (14;18) translocation in at least 90% of patients. Recently, activating EZH2 mutations have been found in a significant number of patients with FL. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

69 Samples

Download data: CEL

(Submitter supplied) Although many protein-coding genes have been identified to be aberrantly expressed in hepatocellular carcinoma (HCC), the mechanisms that account for development and progression of HCC remain unclear. In recent years, long noncoding RNAs (lncRNAs) have been shown to have critical regulatory roles in mammalian cell biology. Many lncRNAs can result in aberrant expression of gene products that may contribute to cancer biology. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by genome tiling array

Platform:

GPL11269

10 Samples

Download data: PAIR