Similar studies for GEO DataSets (Select 4262) - GEO DataSets

Select item 42621.

Oxidized low-density lipoprotein effect on LOX-1 overexpressing aortic endothelial cell line HAECT: time course

Analysis of oxidized-low-density lipoprotein receptor-1 (LOX-1)-overexpressing HAECT cells treated with OxLDL for up to 24 hrs. OxLDL is implicated as a proatherogenic factor. Results provide insight into molecular mechanisms underlying OxLDL-induced endothelial dysfunction and atherosclerosis.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 agent, 2 genotype/variation, 5 time sets

Platform:: GPL570
Series:: GSE13139
54 Samples

Download data: CEL

DataSet

Accession:: GDS4262

ID:: 4262

Select item 2000131392.

LOX-1-dependent transcriptional regulation after oxidized LDL (OxLDL) treatment of human aortic endothelial cells.

(Submitter supplied) LOX-1 is the primary endothelial receptor for oxidized LDL in endothelial cells and plays a role in the development of atherosclerosis. Expression profiling was carried out on samples from HAECT cells over-expressing either LOX-1 or GFP control and treated with or without OxLDL over a time course of 2, 6, 12 and 24 Hours. The goal of the study was to identify genes expression changes activated by OxLDL binding to LOX-1 at several different time points.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4262
Platform:: GPL570
54 Samples

Download data: CEL

Series

Accession:: GSE13139

ID:: 200013139

Select item 2000416363.

Juvenile obesity in Ossabaw swine produces artery-specific transcriptional changes

(Submitter supplied) We adopted a transcriptome-wide microarray analysis approach to determine the extent to which vascular gene expression is altered as a result of juvenile obesity and identify obesity-responsive mRNAs. We examined transcriptional profiles in the left anterior descending coronary artery (LAD), perivascular fat adjacent to the LAD, and descending thoracic aorta between obese (n=5) and lean (n=6) juvenile Ossabaw pigs (age=22 weeks). more...

Organism:: Sus scrofa

Type:: Expression profiling by array

Platform:: GPL3533
32 Samples

Download data: CEL, TXT

Series

Accession:: GSE41636

ID:: 200041636

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002082334.

Lectin-like oxidized low-density receptor-1 attenuates pneumonia-induced lung injury

(Submitter supplied) Identifying host factors that contribute to pneumonia incidence and severity are of utmost importance to guiding the development of more effective therapies. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a scavenger receptor known to promote vascular injury and inflammation, but it is unknown whether and how LOX-1 functions in the lung. Here, we provide evidence of substantial accumulation of LOX-1 in the lungs of ARDS patients and in mice with pneumonia. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
16 Samples

Download data: XLSX

Series

Accession:: GSE208233

ID:: 200208233

PubMed Full text in PMC Similar studies

Select item 2002096025.

Effect of endothelial ADAM10 deficiency on the aorta in an atherosclerosis mouse model

(Submitter supplied) Mice lacking ADAM10 in endothelial cells (Tie2Cre driven) and flox-control mice were injected with an AAV8-PCSK9 virus and put on a Western-type diet for 10 weeks to induce atherosclerosis. Aorta's (Thoracoabdominal) were isolated (removal of PVAT) and processed for RNA-sequencing.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23479
6 Samples

Download data: TSV

Series

Accession:: GSE209602

ID:: 200209602

PubMed Full text in PMC Similar studies

Select item 2000179416.

A Transcriptional Signature and Common Gene Networks Link Cancer with Metabolic Syndrome and Auto-immune Diseases

(Submitter supplied) Epidemiological studies have revealed concurrence of specific cancers with other disease states such as metabolic syndrome, inflammatory disease and autoimmune disease. Patients with these chronic conditions have a higher incidence of various cancers, more aggressive tumors, and a higher mortality rate. It has been proposed that obesity, inflammation and chronic disease should be correlated with cancer at the molecular level, but common gene signatures or networks have yet to be described. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL9188
49 Samples

Download data: CEL

Series

Accession:: GSE17941

ID:: 200017941

PubMed Full text in PMC Similar studies Analyze with GEO2R

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