GEO DataSets

Analysis of postmortem brain of ART-treated, HIV-1-associated neurocognitive disorders (HAND) patients. ART reduces morbidity and mortality in HIV infection, but HAND persist despite treatment. Results provide insight into ART effectiveness in brain and into molecular signatures of HAND under ART.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 2 disease state sets

Platform:

GPL570

Series:

GSE28160

35 Samples

Download data: CEL

(Submitter supplied) Antiretroviral therapy (ART) has reduced morbidity and mortality in HIV infection; however HIV-1-associated neurocognitive disorders (HAND) persist despite treatment. We used microarray analysis in post-mortem brain tissues to determine ART effectiveness in the brain and to identify molecular signatures of HAND under ART.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4231

Platform:

GPL570

35 Samples

Download data: CEL

(Submitter supplied) In this study, using 33 postmortem frontal cortex (FC) tissues, neuropathological, molecular, and biochemical analyses were used to determine cellular localization and validate expression levels of the prolific transcription factor (TF), CCAAT enhancer binding protein (C/EBP) β, in brain tissues from HIV+ cognitively normal and HAND cases. RNA sequencing (seq) and transcriptomic analyses were performed on FC tissues including 24 specimens from well-characterized people with HIV that had undergone neurocognitive assessments. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20301

41 Samples

Download data: TXT

(Submitter supplied) This study aimed at investigating the monocytic transcriptome distinction between patients with sustained virus suppression (BDL) and patients with virological failure during highly active antiretroviral therapy (HAART). This study provides the first transcriptomic distinctions in monocytes between viremic patients and BDLs on HAART. Our results reflected the outcome balanced between subversion of monocyte transcriptome by HIV and compensatory effect adapted by host cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

14 Samples

Download data: TXT

(Submitter supplied) The gene expression patterns of astrocyte harboring active vs restricted LTRs were similar, and that the active population demonstrated more widespread and robust changes.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18573

12 Samples

Download data: TAB

(Submitter supplied) The DALIA-1 trial was designed to evaluate the safety and immunogenicity of a DC-based vaccine generated by culturing blood monocytes with GM-CSF and IFN-a. DCs were pulsed for 24 hrs with the ANRS LIPO5 peptide pool and activated for the last 6 hrs with LPS. In total, 19 asymptomatic HAART-treated patients were included in the study. Microarray samples were collected in both the treatment phase and follow-up phase of the study.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

330 Samples

Download data: TXT

(Submitter supplied) We present a microarray analysis of primary mouse astrocytes exposed to HIV-1 in culture. Results are compared with previous genomic studies of HIV-1 effect in human astrocytes and human and macaque brains.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

6 Samples

Download data: CEL, CHP

(Submitter supplied) Transcriptomic analyses from early human immunodeficiency virus (HIV) infection have the potential to reveal how HIV causes widespread and lasting damage to biological functions, especially in the immune system. Previous studies have been hampered by difficulties in obtaining early specimens. We studied 29 HIV infected subjects 1 month from presentation and 46 contemporaneous uninfected controls. We used RNA-seq to examine circulating immune cells to describe in detail the profound gene dysregulation observed in early HIV infection. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11154

74 Samples

Download data: CSV

(Submitter supplied) Finding the differences in gene expression in three regions of the brain, basal ganglia, white matter, and frontal cortex, in normal, HIV infected, HIV infected with neurocognitive impairment, and HIV infected with both neurocognitive impairment and encephalitis patients.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4358

Platform:

GPL570

72 Samples

Download data: CEL

Analysis of basal ganglia, frontal cortex, and white matter from HIV patients with HIV-associated dementia (HAD) or HAD plus HIV encephalitis (HIVE). Results provide insight into molecular events of neurological impairment and inflammation associated with HIV infection in different brain regions.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 4 disease state, 3 tissue sets

Platform:

GPL570

Series:

GSE35864

72 Samples

Download data: CEL

(Submitter supplied) The extent of HIV immunodeficiency and related diseases has been greatly reduced by suppressive antiretroviral therapy but roughly 50% of infected people continue to develop mild neurocognitive disorder. We established an experimental approach to investigate HIV brain disease by infection of wildtype mice with the chimeric HIV, EcoHIV. The toll-like receptor 3 ligand, polyinosinic-polycytodylic acid (poly I:C), was used to induce innate immune responses prior to or during EcoHIV infection resulting in prevention of infection or reduced virus burden and reversed behavioral disease, respectively. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

12 Samples

Download data: XLSX