GEO DataSets

Analysis of polymorphonuclear cells from patients affected with autosomal dominant monocytopenia characterized by mycobacterial, fungal, and viral infections, and frequently myelodysplasia. RNA extracted using STAT60. Results provide insight into molecular mechanisms underlying this syndrome.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL570

Series:

GSE16020

10 Samples

Download data: CEL, CHP

(Submitter supplied) We identified 18 patients with the distinct clinical phenotype of disseminated nontuberculous mycobacterial infections, viral infections, especially with human papillomaviruses, and fungal infections, primarily histoplasmosis and molds. This syndrome typically had its onset in adulthood and was characterized by profound circulating monocytopenia, B lymphocytopenia, and NK lymphocytopenia. T lymphocytes were variably affected. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS3819 GDS3820

Platform:

GPL570

20 Samples

Download data: CEL, CHP

Analysis of polymorphonuclear cells from patients affected with autosomal dominant monocytopenia characterized by mycobacterial, fungal, and viral infections, and frequently myelodysplasia. RNA extracted using RNeasy. Results provide insight into molecular mechanisms underlying this syndrome.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL570

Series:

GSE16020

10 Samples

Download data: CEL, CHP

(Submitter supplied) Timecourse experiment (0hr, 2hr,6hr and 21hr) where RNA was extracted from non-rested PBMCs which were exposed to 4 different conditions- nothing (mock), interferon (IFN)gamma, IFN gamma and a non-specific antibody and IFN gamma with purified patient antibody. The purified patient antibody is demonstrated to have a specific anti-interferon gamma effect over time, with the expression profile in the arrays with IFN gamma plus patient antibody most closely resembling the mock arrays. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2854

16 Samples

Download data