Similar studies for GEO DataSets (Select 3670) - GEO DataSets

Select item 36701.

Hypochlorous acid effect on macrophage cell line: dose response

Analysis of macrophage RAW 264.7 cells treated with up to 3.5 mM hypochlorous acid (HOCl). HOCl exposure can occur from chlorine gas inhalation or from endogenous sources of HOCl, such as respiratory burst by phagocytes. Results provide insight into the dose-dependent molecular response to HOCl.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 8 dose sets

Platform:: GPL1261
Series:: GSE15457
25 Samples

Download data: CEL

DataSet

Accession:: GDS3670

ID:: 3670

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000154572.

Gene Expression Profiling of Cellular Dose-Response to Hypochlorous Acid (HOCl)

(Submitter supplied) Hypochlorous acid (HOCl) is a potent oxidant that is produced endogenously in mammalian tissue by phagocytes. Exogenous exposure to HOCl also can occur following inhalation of chlorine gas. HOCl has been implicated as a source of oxidative stress associated atherosclerosis and other diseases. The purpose of this study was to identify dose-dependent transitions in cellular response to hypochlorous acid (HOCl), with a focus on understanding how various cellular defense and stress dose-responses overlap.

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3670
Platform:: GPL1261
25 Samples

Download data: CEL

Series

Accession:: GSE15457

ID:: 200015457

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000116303.

HOCL induced airway epithelial gene expression

(Submitter supplied) In inflammatory diseases of the airway, a high level (estimated to be as high as 8 mM) of HOCl can be generated through a reaction catalyzed by the leukocyte granule enzyme myeloperoxidase (MPO). HOCl, a potent oxidative agent, causes extensive tissue injury through its reaction with various cellular substances, including thiols, nucleotides, and amines. In addition to its physiological source, HOCl can also be generated by chlorine gas inhalation from an accident or a potential terrorist attack. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3363
Platform:: GPL571
32 Samples

Download data: CEL

Series

Accession:: GSE11630

ID:: 200011630

Select item 33634.

Airway epithelial cells response to hypochlorous acid: time course

Temporal analysis of primary airway epithelial cells (AEC) treated with 0.4, 1 or 4mM hypochlorous acid (HOCl). HOCl is a potent oxidative agent that can be generated by neutrophils in inflammatory diseases of airways. Results provide insight into mechanisms underlying HOCl-induced toxicity in AECs.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 4 dose, 4 individual, 2 time sets

Platform:: GPL571
Series:: GSE11630
32 Samples

Download data: CEL

DataSet

Accession:: GDS3363

ID:: 3363

Select item 2001243855.

Response of Pseudomonas aeruginosa to the innate immune system-derived oxidants hypochlorous acid and hypothiocyanous acid

(Submitter supplied) Purpose: The aim of this study was to determine the transcriptional response of P. aeruginosa PA14 to HOCl and HOSCN stress, and determine genes dependent on RclR (PA14_07340) regulation. Methods: PA14 WT and ∆rclR exponential phase cultures were exposed to sub-lethal amounts of HOCl or HOSCN (2.2 or 0.8 mM, respectively), or untreated, and after 20 minutes of exposure, RNA was extracted and gene expression analysed by RNA-seq. more...

Organism:: Pseudomonas aeruginosa

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21297
12 Samples

Download data: XLSX

Series

Accession:: GSE124385

ID:: 200124385

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001440686.

RNA sequencing of Escherichia coli Nissle 1917 after HOCl stress

(Submitter supplied) RNA sequencing of Escherichia coli Nissle 1917 before and after HOCl treatment was perfomed to identify pathways that may be important in responding to oxidative stress caused by reachive chlorine species (RCS).

Organism:: Escherichia coli

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21222
9 Samples

Download data: XLSX

Series

Accession:: GSE144068

ID:: 200144068

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000712637.

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(Submitter supplied) Nrf2 (NF-E2-related factor-2) transcription factor regulates oxidative/xenobiotic stress response and also represses inflammation. However, the mechanisms how Nrf2 alleviates inflammation are still unclear. Here, we demonstrate that Nrf2 interferes with lipopolysaccharide-induced transcriptional upregulation of proinflammatory cytokines, including IL-6 and IL-1β. ChIP-seq and ChIP-qPCR analyses revealed that Nrf2 binds to the proximity of these genes in macrophages and inhibits RNA Pol II recruitment. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
12 Samples

Download data: TXT

Series

Accession:: GSE71263

ID:: 200071263

PubMed Full text in PMC Similar studies Analyze with GEO2R

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