GEO DataSets

Analysis of gubernaculum of cryptorchid (orl) fetuses at various gestational days up to GD20. The orl strain is at high risk for cryptorchidism, or undescended testis, one of the most common congenital anomalies in humans. Results provide insight into molecular mechanisms underlying cryptorchidism.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 3 age, 2 gender, 3 other, 2 strain sets

Platform:

GPL341

Series:

GSE7755

34 Samples

Download data: CEL

(Submitter supplied) The Long Evans/orl (LE/orl) rat is an animal model of inherited undescended testis (UDT). To explore genetic mechanisms of UDT, we studied differential gene expression in LE/orl and LE wild type (LE/wt) fetal gubernaculum and testis. Analyses of differentially expressed probe sets linked below as supplementary files: Analysis_methods.txt [A description of the analysis] gub.txt [Genes differentially expressed in between wt and orl gubernacula] testes.txt [Genes differentially expressed between wt and orl testes] wt.txt [Genes differentially expressed in wt gubernacular development] Keywords: strain/condition predisposition, disease state analysis, developmental

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS3156 GDS3157

Platform:

GPL341

54 Samples

Download data: CEL, TXT

Analysis of testis of cryptorchid (orl) fetuses at at various gestational days up to GD19. The orl strain is at high risk for cryptorchidism, or undescended testis, one of the most common congenital anomalies in humans. Results provide insight into molecular mechanisms underlying cryptorchidism.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 age, 2 strain sets

Platform:

GPL341

Series:

GSE7755

20 Samples

Download data: CEL

(Submitter supplied) This study was designed to provide additional insight into testicular hormone production and responsiveness in the orl strain and complement ongoing efforts to characterize the genetic basis of cryptorchidism in this isolated rat colony.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

26 Samples

Download data: CEL

(Submitter supplied) Insl3 is a testis-derived hormone that induces growth and differentiation of the fetal gubernaculum. The goal of this study was to identify genes showing altered expression in fetal gubernaculum following Insl3 exposure.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

17 Samples

Download data: CEL

(Submitter supplied) During male development, the testes move from a high intraabdominal position and descend into the scrotum. The gubernaculum, an inguinoscrotal ligament connecting the testis to the lower abdomen, is believed to play a critical role in this process. The first stage of testicular descent is controlled by INSL3, insulin like3 hormone, produced in testicular Leydig cells. Deletion of Insl3 or its receptor, Rxfp2, in mice causes cryptorchidism. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

6 Samples

Download data: TXT

(Submitter supplied) Spermatogenesis is a complex process involving multiple cells and cellular signals. Among all other cells, Sertoli cells (Sc) are absolutely indispensable for sperm production because they provide biochemical signal and physical support to developing germ cells in the testis. Sc drastically transform during the process of attainment of reproductive maturity. Stage specific gene expression by Sc, supplement for the changing need of developing germ cells. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL7294

9 Samples

Download data: TXT

(Submitter supplied) Accumulating evidences suggest that sex affects lung development. During the fetal period, male lung maturation is delayed compared with female and surfactant production appears earlier in female than in male fetal lungs. We analyzed by microarrays the expression of genes showing a sexual difference and those modulated by endogenous androgens (flutamide).

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

18 Samples

Download data: CEL

(Submitter supplied) This study compares gene expression in the testis of three offshore (Pelican Shoal) and three near-shore (Tingler Island) adult male queen conchs (Strombus gigas) collected from the wild on February 15, 2007.

Organism:

Aliger gigas

Type:

Expression profiling by array

Platform:

GPL8934

6 Samples

Download data: TXT