Similar studies for GEO DataSets (Select 2928) - GEO DataSets

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Items: 13

Select item 29281.

2,3,7,8-tetrachlorodibenzo-p-dioxin effect on the ovary: dose response (II)

Analysis of ovaries following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at concentrations of up to 100 parts per billion (ppb). TCDD is a reproductive toxicant and endocrine disruptor in vertebrates. Results provide insight into molecular mechanisms underlying TCDD toxicity.

Organism:: Danio rerio

Type:: Expression profiling by array, count, 4 dose sets

Platform:: GPL1319
Series:: GSE4859
4 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS2928

ID:: 2928

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000048592.

Molecular targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) within the zebrafish ovary

(Submitter supplied) 2,3,7,8-TCDD (TCDD) is a reproductive toxicant and endocrine disruptor in nearly all vertebrates, yet the mechanisms by which TCDD induces these reproductive alterations have not been fully characterized. Fish are among the most sensitive vertebrates to the toxic effects of TCDD, and even subtle physiologic changes induced by TCDD can impair reproduction. Previously, we have shown that chronic, sub-lethal exposure to TCDD decreased reproductive capacity, reduced serum estradiol and vitellogenin concentrations, and altered follicular development. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Datasets:: GDS2927 GDS2928
Platform:: GPL1319
8 Samples

Download data: CEL, EXP

Series

Accession:: GSE4859

ID:: 200004859

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 29273.

2,3,7,8-tetrachlorodibenzo-p-dioxin effect on the ovary: dose response (I)

Organism:: Danio rerio

Type:: Expression profiling by array, count, 4 dose sets

Platform:: GPL1319
Series:: GSE4859
4 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS2927

ID:: 2927

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000475494.

Toxic effects of dietary TCDD on juvenile zebrafish

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL17210
81 Samples

Download data: CALLS, PAIR

Series

Accession:: GSE47549

ID:: 200047549

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000475475.

Time-dependent toxic effects of dietary TCDD on juvenile zebrafish

(Submitter supplied) Juvenile zebrafish were fed Biodiet starter (4% body weight per day) for 42 d with TCDD added at 0 ppb, 0.1 ppb, 1 ppb, 10 ppb or 100 ppb. Fish were collected, sexed, weighed and length measured at 0, 7, 14, 28 or 42 d for TCDD assessment, histopathologic and microarray analysis. Microarray experiments were conducted using 0 and 100 ppb-TCDD treated male and female sexed zebrafish at 7, 14, 28 and 42 d. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL17210
63 Samples

Download data: CALLS, PAIR

Series

Accession:: GSE47547

ID:: 200047547

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000474346.

Dose-dependent toxic effects of dietary TCDD on juvenile zebrafish

(Submitter supplied) Juvenile zebrafish were fed Biodiet starter (4% body weight per day) for 42 d with TCDD added at 0 ppb, 0.1 ppb, 1 ppb, 10 ppb or 100 ppb. Fish were collected, sexed, weighed and length measured at 0, 7, 14, 28 or 42 d for TCDD assessment, histopathologic and microarray analysis. Microarray experiments were conducted in TCDD-treated (at 0, 0.1, 1, 10 and 100 ppb) for male and female sexed zebrafish at 28 d. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL17210
36 Samples

Download data: CALLS, PAIR

Series

Accession:: GSE47434

ID:: 200047434

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000610397.

Transcriptional Profiling of rat hypothalamic response to TCDD

(Submitter supplied) In many mammals, halogenated aromatic hydrocarbon (HAH) exposure causes wasting syndrome, defined as lethal weight loss as a result of severe and persistent hypophagia. The most potent HAH in causing wasting is 2,3,7,8-tetrachlorodibenzo-ρ-dioxin (TCDD), which exerts its toxic effects through the aryl hydrocarbon receptor (AHR) – a transcription factor. Because TCDD toxicity is thought to predominantly arise from dysregulation of AHR-transcribed genes, we hypothesized that wasting syndrome is due to TCDD-induced dysregulation of genes involved in regulation of food-intake. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL19144
16 Samples

Download data: CEL, TXT

Series

Accession:: GSE61039

ID:: 200061039

Select item 2000183018.

Transcriptional profiling of the rat adipose tissue response to TCDD

(Submitter supplied) Rodents exposed to the environmental contaminant, TCDD, suffer from a number of acute and chronic toxicities, including lethality and a wasting syndrome. Hypothesizing that the wasting syndrome may be caused by changes in adipose tissue -- either in its hormonal regulation or in homeostatic effects -- we profiled the transcriptional response of rat white adipose to TCDD. We employed two separate rat strains: the Long-Evans strain is sensitive to TCDD toxicities while the Han/Wistar strain is over four orders of magnitude more resistant. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL9199
28 Samples

Download data: CEL, DAT

Series

Accession:: GSE18301

ID:: 200018301

Select item 2000324599.

Dioxin effect on the pituitary and hypothalamic expression of genes in male fetal Wistar rats

(Submitter supplied) 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) causes the many forms of reproductive toxicity, such as defects in sexual behaviors, in pups of which mother is exposed to this substance at lower doses. However, the mechanism underlying these defects remains to be clarified in spite of many researches conducted so far. Our previous studies have revealed that maternal treatment with TCDD attenuates the production of pituitary gonadotropins [luteinizing hormone (LH) and follicle-stimulating hormone] in the late fetuses, leading to the impairment of sexual behavior in adulthood. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL6101
12 Samples

Download data: TXT

Series

Accession:: GSE32459

ID:: 200032459

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004991510.

Transcriptomic analyses of TCDD treated zebrafish liver

(Submitter supplied) To fully understand molecular toxicity of TCDD in an in vivo animal model, adult zebrafish were exposed to TCDD at 10 nM for 96 h and the livers were sampled for RNA-sequencing based transcriptomic profiling. A total of 1,058 differently expressed genes were identified based on fold-change>2 and TPM (transcripts per million) >10. Among the top 20 up-regulated genes, 10 novel responsive genes were identified and verified by qRT-PCR analysis on independent samples. more...

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL10658
2 Samples

Download data: TXT

Series

Accession:: GSE49915

ID:: 200049915

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20017241811.

TCDD exposure in control and wfikkn1mutant zebrafish at 48 hpf

(Submitter supplied) This experiment investigates the role of a novel AHR-regulated gene on the global transcriptome in 48 hpf zebrafish exposed to 0.1% DMSO or 1 ng/mL TCDD.

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL14875
16 Samples

Download data: TXT, XLSX

Series

Accession:: GSE172418

ID:: 200172418

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20000281212.

Fetal mouse heart, TCDD dose-response series

(Submitter supplied) Pregnant C57Bl6N mice were treated with 0 (corn oil), 1.5, 3.0, or 6.0 ug/kg TCDD on gd14.5. Fetal hearts were collected on gd17.5. Hearts from each litter were pooled onto one chip. 4 replicates of each condition were run on affymetrix MG_U74Av2 chips, using standard affymetrix protocols and controls. Keywords: dose-response, 3 doses plus corn oil control, 4 replicates

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS1302
Platform:: GPL81
20 Samples

Download data: CEL

Series

Accession:: GSE2812

ID:: 200002812

Select item 130213.

2,3,7,8-tetrachlorodibenzo-p-dioxin effect on cardiovascular development

Analysis of gestational day (GD) 17.5 fetal hearts isolated from pregnant C57BL/6Ns treated at GD 14.5 with up to 6.0 ug/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). TCDD, a cardiovascular teratogen, inhibits cardiomyocyte proliferation, a process that peaks between GD 14.5 to 17.5.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 agent, 4 dose sets

Platform:: GPL81
Series:: GSE2812
20 Samples

Download data: CEL

DataSet

Accession:: GDS1302

ID:: 1302

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Similar studies for GEO DataSets (Select 2928) (13)
GEO DataSets
Prph peripherin [Mus musculus]
Prph peripherin [Mus musculus]
Gene ID:19132

Gene
pseudouridylate synthase 1 homolog isoform 3 [Mus musculus]
pseudouridylate synthase 1 homolog isoform 3 [Mus musculus]
gi|70906472|ref|NP_001020733.1|

Protein
Mus musculus adult male spinal cord cDNA, RIKEN full-length enriched library, cl...
Mus musculus adult male spinal cord cDNA, RIKEN full-length enriched library, clone:A330066G08 product:pseudouridine synthase 1, full insert sequence
gi|74216026|dbj|AK138570.1|

Nucleotide
Mus musculus brain cDNA, clone MNCb-0873, similar to Mus musculus pseudouridine ...
Mus musculus brain cDNA, clone MNCb-0873, similar to Mus musculus pseudouridine synthase 1 (Pus1) mRNA
gi|7670390|dbj|AB041563.1|

Nucleotide

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