Similar studies for GEO DataSets (Select 2653) - GEO DataSets

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Items: 2

Select item 26531.

Sequestosome 1 and dipeptidylpeptidase III overexpression effect on neuroblastoma cell line

Analysis of IMR-32 neuroblastoma cells overexpressing sequestosome 1 (SQSTM1) or dipeptidylpeptidase III (DPP3). SQSTM1 and DPP3 activate the antioxidant response element (ARE). Results provide insight into mechanisms regulating the activation of the ARE.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 protocol sets

Platform:: GPL570
Series:: GSE6451
6 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS2653

ID:: 2653

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000064512.

A genomic screen for activators of the antioxidant response element

(Submitter supplied) The antioxidant response element (ARE) is a cis-acting regulatory enhancer element found in the 5’ flanking region of many phase II detoxification enzymes. Upregulation of ARE-dependent target genes is known to have neuroprotective effects; yet, the mechanism of activation is largely unknown. By screening an arrayed collection of approximately 15,000 full-length expression cDNAs in the human neuroblastoma cell line IMR-32 with an ARE-luciferase reporter, we have identified several cDNAs not previously associated with ARE activation. more...