Similar studies for GEO DataSets (Select 2573) - GEO DataSets

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Items: 4

Select item 25731.

Far-upstream element binding protein inactivation

Analysis of primary skin fibroblasts (Hs68) following siRNA knockdown of far-upstream element binding protein (FBP) 1, 2, or 3. Results provide insight into the function of each member of the FBP transactivator family.

Organism:: Homo sapiens

Type:: Expression profiling by array, log2 ratio, 3 protocol sets

Platform:: GPL3779
Series:: GSE4914
6 Samples

Download data: GPR

DataSet

Accession:: GDS2573

ID:: 2573

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000049142.

RNAi analysis of the FBP transactivator family

(Submitter supplied) The FBP (FUSE Binding Protein) transcription factor family is composed of three highly related members; FBP/FBP1, FBP2, and FBP3. While they all share distinct modular protein structures and nucleic acid-binding specificities, their transactivator strength is graded and they also differ in their interaction with their protein partners. Especially from the extensive nuclear co-localization of these molecules, we anticipated that they co-regulate a set of common target genes. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2573
Platform:: GPL3779
6 Samples

Download data: GPR

Series

Accession:: GSE4914

ID:: 200004914

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000556923.

FIR inhibition in HCC cells (Hep3B)

(Submitter supplied) siRNA-mediated inhibition compared to untreated cells and cells transfected with nonsense siRNA Together with far upstream element binding protein (FBP), the FBP-interacting repressor (FIR) represents a molecular tool for the transcriptional fine tune regulation of target genes. Previous evidence indicates that strong overexpression of FBP in human hepatocellular carcinoma (HCC) supports tumor growth and correlates with poor patient prognosis. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17556
6 Samples

Download data: CEL

Series

Accession:: GSE55692

ID:: 200055692

Select item 2000136464.

Global effect of JTV or JTV-Alt overexpression in HeLa cells

(Submitter supplied) JTV is not only a structural component of multi-aminoacyl-tRNA synthetase complex, but also a regulator of FBP that in turn controls c-Myc expression. In order to identify JTV target genes other than FBP and c-Myc, JTV or JTV-Alt (alternatively spliced form of JTV, enriched in the nucleus) protein was over-expressed in HeLa cells and global gene expression changes were monitored using cDNA expression microarray.