GEO DataSets

Analysis of LNCaP cells treated for 6 and 24 hours with RTI-018, an androgen receptor (AR) ligand with a mechanism of action different from that of canonical agonists. Results provide insight into the link between RTI-018 induced AR conformational changes and its ability to regulate gene expression.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 agent, 2 time sets

Platform:

GPL97

Series:

GSE4636

18 Samples

Download data: CEL

(Submitter supplied) We have previously identified a family of novel androgen receptor (AR) ligands that, upon binding, enable AR to adopt structures distinct from that observed in the presence of canonical agonists. In this report, we describe the use of these compounds to establish a relationship between AR structure and biological activity with a view to defining a rational approach with which to identify useful Selective Androgen Receptor Modulators (SARMs). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS2057 GDS2058

Platforms:

GPL97 GPL96

36 Samples

Download data: CEL

Analysis of LNCaP cells treated for 6 and 24 hours with RTI-018, an androgen receptor (AR) ligand with a mechanism of action different from that of canonical agonists. Results provide insight into the link between RTI-018 induced AR conformational changes and its ability to regulate gene expression.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 agent, 2 time sets

Platform:

GPL96

Series:

GSE4636

18 Samples

Download data: CEL

(Submitter supplied) Androgen receptor (AR) is overexpressed in the majority of castration-resistant prostate cancers (CRPCs). Our goal was to study the effect of AR overexpression on the chromatin binding of the receptor and to identify AR target genes that may be important in the emergence of CRPC. We have established two sublines of LNCaP prostate cancer (PC) cell line, one overexpressing AR 2–3-fold and the other 4–5-fold compared with the control cells. more...

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL9115

13 Samples

Download data: BED