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Links from GEO DataSets

Items: 4

1.
Full record GDS2058

Androgen receptor modulator effect: time course (HG-U133B)

Analysis of LNCaP cells treated for 6 and 24 hours with RTI-018, an androgen receptor (AR) ligand with a mechanism of action different from that of canonical agonists. Results provide insight into the link between RTI-018 induced AR conformational changes and its ability to regulate gene expression.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 agent, 2 time sets
Platform:
GPL97
Series:
GSE4636
18 Samples
Download data: CEL
DataSet
Accession:
GDS2058
ID:
2058
2.

Differential redulation of gene expression by an RTI SARM and canonical agonist of androgen receptor

(Submitter supplied) We have previously identified a family of novel androgen receptor (AR) ligands that, upon binding, enable AR to adopt structures distinct from that observed in the presence of canonical agonists. In this report, we describe the use of these compounds to establish a relationship between AR structure and biological activity with a view to defining a rational approach with which to identify useful Selective Androgen Receptor Modulators (SARMs). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS2057 GDS2058
Platforms:
GPL97 GPL96
36 Samples
Download data: CEL
Series
Accession:
GSE4636
ID:
200004636
3.
Full record GDS2057

Androgen receptor modulator effect: time course (HG-U133A)

Analysis of LNCaP cells treated for 6 and 24 hours with RTI-018, an androgen receptor (AR) ligand with a mechanism of action different from that of canonical agonists. Results provide insight into the link between RTI-018 induced AR conformational changes and its ability to regulate gene expression.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 agent, 2 time sets
Platform:
GPL96
Series:
GSE4636
18 Samples
Download data: CEL
DataSet
Accession:
GDS2057
ID:
2057
4.

Overexpression of androgen receptor enhances the binding of the receptor to the chromatin in prostate cancer

(Submitter supplied) Androgen receptor (AR) is overexpressed in the majority of castration-resistant prostate cancers (CRPCs). Our goal was to study the effect of AR overexpression on the chromatin binding of the receptor and to identify AR target genes that may be important in the emergence of CRPC. We have established two sublines of LNCaP prostate cancer (PC) cell line, one overexpressing AR 2–3-fold and the other 4–5-fold compared with the control cells. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9115
13 Samples
Download data: BED
Series
Accession:
GSE48308
ID:
200048308
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Supplemental Content

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