Similar studies for GEO DataSets (Select 2058) - GEO DataSets

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Items: 4

Select item 20581.

Androgen receptor modulator effect: time course (HG-U133B)

Analysis of LNCaP cells treated for 6 and 24 hours with RTI-018, an androgen receptor (AR) ligand with a mechanism of action different from that of canonical agonists. Results provide insight into the link between RTI-018 induced AR conformational changes and its ability to regulate gene expression.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 agent, 2 time sets

Platform:: GPL97
Series:: GSE4636
18 Samples

Download data: CEL

DataSet

Accession:: GDS2058

ID:: 2058

Select item 2000046362.

Differential redulation of gene expression by an RTI SARM and canonical agonist of androgen receptor

(Submitter supplied) We have previously identified a family of novel androgen receptor (AR) ligands that, upon binding, enable AR to adopt structures distinct from that observed in the presence of canonical agonists. In this report, we describe the use of these compounds to establish a relationship between AR structure and biological activity with a view to defining a rational approach with which to identify useful Selective Androgen Receptor Modulators (SARMs). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Datasets:: GDS2057 GDS2058
Platforms:: GPL97 GPL96
36 Samples

Download data: CEL

Series

Accession:: GSE4636

ID:: 200004636

Select item 20573.

Androgen receptor modulator effect: time course (HG-U133A)

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 agent, 2 time sets

Platform:: GPL96
Series:: GSE4636
18 Samples

Download data: CEL

DataSet

Accession:: GDS2057

ID:: 2057

Select item 2000483084.

Overexpression of androgen receptor enhances the binding of the receptor to the chromatin in prostate cancer

(Submitter supplied) Androgen receptor (AR) is overexpressed in the majority of castration-resistant prostate cancers (CRPCs). Our goal was to study the effect of AR overexpression on the chromatin binding of the receptor and to identify AR target genes that may be important in the emergence of CRPC. We have established two sublines of LNCaP prostate cancer (PC) cell line, one overexpressing AR 2–3-fold and the other 4–5-fold compared with the control cells. more...