Similar studies for GEO DataSets (Select 200193438) - GEO DataSets

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Items: 3

Select item 2001934381.

Differential Neuropathology, Genetics, and Transcriptomics in two kindred cases with Alzheimer’s Disease and Lewy Body Dementia

(Submitter supplied) Alzheimer’s disease (AD) and Lewy body dementia (LBD) are two different forms of dementia but their pathology may involve the same cortical areas with overlapping cognitive manifestation. Dementia cases within the same family share a common genetic background. Nonetheless, the clinical phenotype may be different due to the different underlying molecular processes that come-up apart from genetics, causing diverse neurodegeneration. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
48 Samples

Download data: RESULTS

Series

Accession:: GSE193438

ID:: 200193438

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000844222.

Molecular Signatures Underlying Selective Regional Vulnerability to Alzheimer's Disease

(Submitter supplied) Alzheimer's disease (AD) is the most common form of dementia, characterized by progressive cognitive impairment and neurodegeneration as a result of abnormal neuronal loss. To elucidate the molecular systems associated with AD, we characterized the gene expression changes associated with multiple clinical and neuropathological traits in 1,053 postmortem brain samples across 19 brain regions from 125 persons dying with varying severities of dementia and variable AD-neuropathology severities.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL570 GPL96 GPL97
2004 Samples

Download data: CEL

Series

Accession:: GSE84422

ID:: 200084422

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000132143.

Evaluation of gene expression profile in postmortem brain with Alzheimer´s disease-type neuropathological changes

(Submitter supplied) Unravel the mechanisms underlying brain aging and Alzheimer´s disease (AD) has been difficult because of complexity of the networks that drive these aging-related changes. Analysis of the gene expression in the brain is a valuable tool to study the function of the brain under normal and pathological conditions. Gene microarray technology allows massively parallel analysis of most genes expressed in a tissue, and therefore is an important research tool that potentially can provide the investigative power needed to address the complexity of brain aging and neurodegenerative processes. more...