GEO DataSets

(Submitter supplied) Bats harbor high-impact zoonotic viruses in absence of clinical disease, which has been recently associated with unique features of their immune system. They seem to restrict inflammation and possibly limit disease manifestation to a minimum. In-depth characterization of cellular immunity in bats is yet largely missing, and imprinting of age and development on immune cell compartments remains unexplored. more...

Organism:

Rousettus aegyptiacus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30616

4 Samples

Download data: MTX, TSV, TXT

(Submitter supplied) Abstract from accompanying publication: "Bats host a number of viruses that cause severe disease in humans without experiencing overt symptoms of disease themselves. While the mechanisms underlying this ability to avoid sickness are not known, deep sequencing studies of bat genomes have uncovered genetic adaptations that may have functional importance in the antiviral response of these animals. Egyptian rousette bats (Rousettus aegyptiacus) are the natural reservoir hosts of Marburg virus (MARV). more...

Organism:

Rousettus aegyptiacus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24487

66 Samples

Download data: TXT

(Submitter supplied) Study was performed in order to determine the type and scope of interferon response of Rousettus aegyptiacus-derived fibroblasts to Sendai virus infection. This study helps to understand the function of the expanded immune repertoire of Rosettus aegyptiacus.

Organism:

Rousettus aegyptiacus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24487

18 Samples

Download data: GFF, H5

(Submitter supplied) Study was performed in order to determine the scope of antiviral response of Rousettus aegyptiacus-derived fibroblasts to Sendai and Marburg virus infection. This study aids in understanding the function of the expanded immune repertoire of Rosettus aegyptiacus.

Organism:

Rousettus aegyptiacus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24487

36 Samples

Download data: GFF, H5

(Submitter supplied) The liver plays a critical role in both immune defense and tolerance in the body. The liver-resident immune cells (LrICs) determine the immune properties, but the unique composition and heterogeneity of these cells are incompletely understood. Here, we dissect the diversity of LrICs by a comprehensive transcriptomic profiling using the unbiased single-cell RNA-sequencing (scRNA-seq). A total of 70, 706 of CD45+ immune cells from the paired liver perfusion, spleen and peripheral blood as references were profiled. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20795

9 Samples

Download data: MTX, TSV