Similar studies for GEO DataSets (Select 200155493) - GEO DataSets

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Items: 2

Select item 2001554931.

The Caspase-Activated DNAse drives chromosomal instability and cancer metastasis

(Submitter supplied) Chromosome-segregation errors in cancer cells are linked to chromosomal instability, the appearance of micronuclei and subsequent intracellular signaling events that drive cancer metastasis. The cause of these aberrations is not well-defined but a link to DNA-damage has been established. The Caspase-Activated DNAse (CAD) has been discovered for its role in the degradation of DNA in apoptotic cells but can also be activated in the absence of cell death. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
23 Samples

Download data: TXT

Series

Accession:: GSE155493

ID:: 200155493

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2002129562.

The DNA-damage response triggered by the caspase-activated DNAse contributes to inflammation and immune response

(Submitter supplied) A DNA-damage response (DDR) occurs upon physical and chemical insults to genomic DNA and drives inflammation. The caspase-activated DNAse (CAD) is a nuclear enzyme that degrades DNA during apoptosis but that can also be activated by sub-lethal signals in the mitochondrial apoptosis pathway. Viral and bacterial agents of disease trigger such sub-lethal signals in infected cells and cause the activation of CAD. more...