GEO DataSets

(Submitter supplied) Germ-free mice were colonized as neonates with either a simplified human infant microbiota consortium consisting of four Bifidobacterium species, or with a complex, conventional murine microbiota. Cultures were combined in equal ratios based on OD600 readings (volume equal to approximately OD600 1.0 for each of the species), pelleted, then re-suspended in 3 mL sterile PBS. Colonization of males and females with bifidobacteria was achieved by administering 0.2 mL of this treatment directly to the stomach of each dam via oral gavage on alternating days post-partum. more...

Organism:

Mus musculus

Type:

Expression profiling by RT-PCR

Platform:

GPL27919

27 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL13112 GPL21103

29 Samples

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(Submitter supplied) Neuronal synapse formation and remodeling is essential to central nervous system (CNS) development and is dysfunctional in neurodevelopmental diseases. Innate immune signals regulate tissue remodeling in the periphery, but how this impacts CNS synapses is largely unknown. Here we show that the IL-1 family cytokine Interleukin-33 (IL-33) is produced by developing astrocytes and is developmentally required for normal synapse numbers and neural circuit function in the spinal cord and thalamus. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

13 Samples

Download data: TXT

(Submitter supplied) Neuronal synapse formation and remodeling is essential to central nervous system (CNS) development and is dysfunctional in neurodevelopmental diseases. Innate immune signals regulate tissue remodeling in the periphery, but how this impacts CNS synapses is largely unknown. Here we show that the IL-1 family cytokine Interleukin-33 (IL-33) is produced by developing astrocytes and is developmentally required for normal synapse numbers and neural circuit function in the spinal cord and thalamus. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21103

16 Samples

Download data: TXT

(Submitter supplied) Development of the human gut microbiota commences at birth with bifidobacteria being among the first colonizers of the sterile newborn gastrointestinal tract. To date the genetic basis of bifidobacterial colonization and persistence remains poorly understood. Transcriptomic analysis of the 2,422,684 bp genome of Bifidobacterium breve UCC2003, a strain isolated from a nursling stool, during colonization of a mouse model revealed the differential expression of a type IVb or so-called Tad pilus-encoding cluster. more...

Organism:

Bifidobacterium breve; Bifidobacterium breve UCC2003; Mus musculus

Type:

Expression profiling by array; Genome variation profiling by array

Platforms:

GPL13210 GPL8878

21 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Bifidobacterium bifidum PRL2010; Bifidobacterium adolescentis; Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088; Bifidobacterium breve 12L

Type:

Expression profiling by array

Platform:

GPL19766

20 Samples

Download data: TXT

(Submitter supplied) We describe the molecular cross talk established under in vivo conditions between a set of human gut bifidobacterial commensals. Eleven groups of five conventional female 8-wk-old BALB/c mice taking a standard polysaccharide-rich Chow diet were administered a single daily dose of 109 CFU of either B. bifidum PRL2010, B. breve 12L , B. adolescentis 22L , B. longum subsp. infantis ATCC15697, or bifidobacterial couples, i.e., PRL2010-12L, PRL2010-22L, PRL2010-ATCC15696, 12L-22L, 12L-ATCC15697, 22L-ATCC15697, or a combination of all bifidobacterial strains. more...

Organism:

Bifidobacterium adolescentis; Bifidobacterium breve 12L; Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088; Bifidobacterium bifidum PRL2010

Type:

Expression profiling by array

Platform:

GPL19766

5 Samples

Download data: TXT

(Submitter supplied) We describe the molecular cross talk established under in vivo conditions between a set of human gut bifidobacterial commensals. Eleven groups of five conventional female 8-wk-old BALB/c mice taking a standard polysaccharide-rich Chow diet were administered a single daily dose of 109 CFU of either B. bifidum PRL2010, B. breve 12L , B. adolescentis 22L , B. longum subsp. infantis ATCC15697, or bifidobacterial couples, i.e., PRL2010-12L, PRL2010-22L, PRL2010-ATCC15696, 12L-22L, 12L-ATCC15697, 22L-ATCC15697, or a combination of all bifidobacterial strains. more...

Organism:

Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088; Bifidobacterium breve 12L; Bifidobacterium adolescentis; Bifidobacterium bifidum PRL2010

Type:

Expression profiling by array

Platform:

GPL19766

5 Samples

Download data: TXT

(Submitter supplied) We describe the molecular cross talk established under in vivo conditions between a set of human gut bifidobacterial commensals. Eleven groups of five conventional female 8-wk-old BALB/c mice taking a standard polysaccharide-rich Chow diet were administered a single daily dose of 109 CFU of either B. bifidum PRL2010, B. breve 12L , B. adolescentis 22L , B. longum subsp. infantis ATCC15697, or bifidobacterial couples, i.e., PRL2010-12L, PRL2010-22L, PRL2010-ATCC15696, 12L-22L, 12L-ATCC15697, 22L-ATCC15697, or a combination of all bifidobacterial strains. more...

Organism:

Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088; Bifidobacterium breve 12L; Bifidobacterium bifidum PRL2010; Bifidobacterium adolescentis

Type:

Expression profiling by array

Platform:

GPL19766

5 Samples

Download data: TXT

(Submitter supplied) We describe the molecular cross talk established under in vivo conditions between a set of human gut bifidobacterial commensals. Eleven groups of five conventional female 8-wk-old BALB/c mice taking a standard polysaccharide-rich Chow diet were administered a single daily dose of 109 CFU of either B. bifidum PRL2010, B. breve 12L , B. adolescentis 22L , B. longum subsp. infantis ATCC15697, or bifidobacterial couples, i.e., PRL2010-12L, PRL2010-22L, PRL2010-ATCC15696, 12L-22L, 12L-ATCC15697, 22L-ATCC15697, or a combination of all bifidobacterial strains. more...

Organism:

Bifidobacterium adolescentis; Bifidobacterium bifidum PRL2010; Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088; Bifidobacterium breve 12L

Type:

Expression profiling by array

Platform:

GPL19766

5 Samples

Download data: TXT

(Submitter supplied) This study profiles developing and adult zebrafish macrophages and defines regional and functional microglial subtypes.

Organism:

Danio rerio

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24995

3 Samples

Download data: CSV, TXT

(Submitter supplied) This study profiles developing and adult zebrafish macrophages and defines regional and functional microglial subtypes.

Organism:

Danio rerio

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21741

9 Samples

Download data: CSV

(Submitter supplied) We performed high-throughput snRNA-seq on hippocampus (Hip) and prefrontal lobe cortex (PFC) tissue in mice (Mus musculus) to identify cell-type specific differentially expressed genes. Mice were divided into GF, SPF and CGF group.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

18 Samples

Download data: MTX, TSV