GEO DataSets

(Submitter supplied) To characterize atherosclerotic plaque cells we isolated cells from the body of vulnerable and stable human atherosclerotic plaques and performed RNA-Seq gene expression profiling of obtained samples.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

4 Samples

Download data: XLSX

(Submitter supplied) Objective: Resident macrophages play an important role in atheromatous plaque rupture. The macrophage gene expression signature associated with plaque rupture is incompletely defined due to the complex cellular heterogeneity in the plaque. We aimed to characterise differential gene expression in resident plaque macrophages from ruptured and stable human atheromatous lesions. A cell-specific approach has the potential to address the question of gene expression differences between particular cell types in stable and unstable plaques with greater precision than approaches based on the study of whole plaques. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

11 Samples

Download data: CEL, TXT

(Submitter supplied) In order to identify potential new biomarkers of atherosclerotic plaque composition we performed a large scale analysis of gene expression patterns in human atherosclerotic lesions. Whole genome expression analysis of 101 peripheral plaques identified a robust gene signature (1514 genes) dominated by inflammatory processes, and cholesterol metabolism and storage genes. Specific pathways enriched in this signature included activation of the Toll-like receptor signaling pathway, T-cell activation, cholesterol efflux, oxidative stress response, inflammatory cytokine production, vasoconstriction and lysosomal activity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10687

113 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL10687 GPL4372

521 Samples

Download data: CEL

(Submitter supplied) In order to identify potential new biomarkers of atherosclerotic plaque composition we performed a large scale analysis of gene expression patterns in human atherosclerotic lesions. Whole genome expression analysis of 101 peripheral plaques identified a robust gene signature (1514 genes) dominated by inflammatory processes, and cholesterol metabolism and storage genes. Specific pathways enriched in this signature included activation of the Toll-like receptor signaling pathway, T-cell activation, cholesterol efflux, oxidative stress response, inflammatory cytokine production, vasoconstriction and lysosomal activity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4372

109 Samples

Download data

(Submitter supplied) In order to identify potential new biomarkers of atherosclerotic plaque composition we performed a large scale analysis of gene expression patterns in human atherosclerotic lesions. Whole genome expression analysis of 101 peripheral plaques identified a robust gene signature (1514 genes) dominated by inflammatory processes, and cholesterol metabolism and storage genes. Specific pathways enriched in this signature included activation of the Toll-like receptor signaling pathway, T-cell activation, cholesterol efflux, oxidative stress response, inflammatory cytokine production, vasoconstriction and lysosomal activity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4372

9 Samples

Download data

(Submitter supplied) Using single-cell proteomic and transcriptomic analyses, we uncovered distinct features of both T cells and macrophages in carotid artery plaques of patients with clinically symptomatic disease (recent stroke or transient ischemic attack) compared to asymptomatic disease (no recent stroke). Additionally, macrophages from these plaques contained alternatively activated phenotypes, including subsets associated with plaque vulnerability. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20301

9 Samples

Download data: MTX, TSV

(Submitter supplied) We used microarray analyses in human atherosclerotic plaque to identify network imply in the maintenance and progression of the pathology. To obtain a wide dynamic range we used the scanning method proposed by Skibbe et al. (Bioinformatics. 2006;22(15):1863-1870) performing three subsequent scansions for the same slide. We performed before low than medium and high PMT and laser intensity scansions to permit to detect differences in expression of high expressed genes from the first scansion and from low expressed genes from the last scansion. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS3696 GDS3697 GDS3698

Platform:

GPL6647

66 Samples

Download data: TXT

Analysis of 8 atherosclerotic LAD coronaries presenting at least 75% stenosis and calcified plaques. Atherosclerosis affects aorta, coronary, carotid, and iliac arteries more frequently than any other vessel. Results provide insight into molecular networks underlying the atherosclerotic condition.

Organism:

Homo sapiens

Type:

Expression profiling by array, log2 ratio, 8 individual sets

Platform:

GPL6647

Series:

GSE11138

22 Samples

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Analysis of 8 atherosclerotic LAD coronaries presenting at least 75% stenosis and calcified plaques. Atherosclerosis affects aorta, coronary, carotid, and iliac arteries more frequently than any other vessel. Results provide insight into molecular networks underlying the atherosclerotic condition.

Organism:

Homo sapiens

Type:

Expression profiling by array, log2 ratio, 8 individual sets

Platform:

GPL6647

Series:

GSE11138

22 Samples

Download data

Analysis of 8 atherosclerotic LAD coronaries presenting at least 75% stenosis and calcified plaques. Atherosclerosis affects aorta, coronary, carotid, and iliac arteries more frequently than any other vessel. Results provide insight into molecular networks underlying the atherosclerotic condition.

Organism:

Homo sapiens

Type:

Expression profiling by array, log2 ratio, 8 individual sets

Platform:

GPL6647

Series:

GSE11138

22 Samples

Download data

(Submitter supplied) Microarray transcriptional profiling of carotid atherosclerotic plaques taken from symptomatic patients undergoing carotid endarterectomy surgery.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6104

43 Samples

Download data: TXT

(Submitter supplied) Atherogenesis involves an interplay of inflammation, tissue remodeling and cellular transdifferentiation (CTD), making it especially difficult to precisely delineate its pathophysiology. Here we examine the single-cell transcriptome of entire calcified atherosclerotic core (AC) plaques and patient-matched proximal adjacent (PA) portions of carotid artery tissue from patients undergoing carotid endarterectomy. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18573

6 Samples

Download data: H5, TAR, TXT