Similar studies for GEO DataSets (Select 200079609) - GEO DataSets

(Submitter supplied) We profiled DNA copy numbers, DNA methylation, and mRNA expression levels in the same HCC patients. To identify genes which transcriptional expression levels are regulated by genomic and/or epigenetic deregulation, we defined the copy number-correlated and methylation-correlated genes with their corresponding gene expression levels across the samples as genic and epigenetic deregulators, respectively.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6947
94 Samples

Download data: TXT

Series

Accession:: GSE87630

ID:: 200087630

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001503227.

Epigenomic effect of talc particles on macrophages

(Submitter supplied) Our objective was to investigate epigenomic and transcriptomic changes in J774 macrophages after incubation with talc and titanium dioxide particles. This dataset comprises the results of reduced representation bisulfite sequencing (RRBS) of the J774 cell DNA 24 hours after exposure to 10 ug/well of fine-sized talc or titanium dioxide particles in vitro with or without 2 ug/mL 17-b estradiol.

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL24247
18 Samples

Download data: COV, TXT

Series

Accession:: GSE150322

ID:: 200150322

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000687988.

Integrated metabolic modelling reveals cell-type specific epigenetic control points of the macrophage metabolic network

(Submitter supplied) The reconstruction of cell type- and patient-specific metabolic models from easily and reliably measurable features such as transcriptomics data will be increasingly important at the age of personalized medicine. Current reconstruction methods suffer from high computational effort and arbitrary threshold setting. Moreover, understanding the underlying epigenetic regulation might allow the identification of putative intervention points within metabolic networks. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9115
6 Samples

Download data: BED

Series

Accession:: GSE68798

ID:: 200068798

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000270789.

LID ChIP-Seq in wild type, and H3K4me3 ChIP-Seq in wild type and lid RNAi Drosophila melanogaster

(Submitter supplied) LID is a histone demethylase acting on H3K4me3, a mark related to transcription and found near the transcription start sites (TSS) of the genes. We analyzed where LID is localized and the effects of LID downregulation in the distribution of H3K4me3.

Organism:: Drosophila melanogaster

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9061
10 Samples

Download data: BED, TXT

Series

Accession:: GSE27078

ID:: 200027078

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009290110.

Distinct Sets Of Genes Representing Overlapping Biological Functions Are Altered By Intrinsic Properties Of Carbon Nanomaterials In Vitro And In Vivo

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by array

Platforms:: GPL10332 GPL13912
72 Samples

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Series

Accession:: GSE92901

ID:: 200092901

Select item 20009290011.

Distinct Sets Of Genes Representing Overlapping Biological Functions Are Altered By Intrinsic Properties Of Carbon Nanomaterials In Vitro And In Vivo [mouse]

(Submitter supplied) Six different carbon nanomaterials (CNM) administered by oropharyngeal aspiration to C57BL/6 mice (on 4 consecutive days with 10ug of CNM per day in PBS, sacrificed on 5th day) and to differentiated THP-1 cells in culture (6 hour and 24 hour, with 100ug of CNM /ml of medium)

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13912
24 Samples

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Series

Accession:: GSE92900

ID:: 200092900

Select item 20009289912.

Distinct Sets Of Genes Representing Overlapping Biological Functions Are Altered By Intrinsic Properties Of Carbon Nanomaterials In Vitro And In Vivo [human]

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10332
48 Samples

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Series

Accession:: GSE92899

ID:: 200092899

Select item 20018393513.

Genomic and epigenetics guided identification of tissue-specific genomic safe harbor sites for gene therapy

(Submitter supplied) One common strategy in gene and cell therapies requires the integration and stable transcription of transgenes into the host cell genomes. Genomic safe harbors (GSHs) are regions of the genome that can maintain the expression of transgenes without disrupting the transcriptome of host cells. With recent advances in genome editing technology, GSHs play an increasingly important role in improving the efficiency and safety of genome engineering. more...