Similar studies for GEO DataSets (Select 200069656) - GEO DataSets

Links from GEO DataSets

Items: 20

Select item 2000696561.

An Alternative Splicing Event Amplifies Evolutionary Differences Between Vertebrates

(Submitter supplied) Alternative splicing (AS) generates extensive transcriptomic and proteomic complexity. However, the functions of species- and lineage-specific splice variants are largely unknown. Here, we show that mammalian-specific skipping of exon 9 of PTBP1 alters its splicing regulatory activities and affects the inclusion levels of numerous exons. During neurogenesis, skipping of exon 9 reduces PTBP1 repressive activity so as to facilitate activation of a brain-specific AS program. more...

Organism:: Gallus gallus; Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL16791 GPL19005
14 Samples

Download data: TAB

Series

Accession:: GSE69656

ID:: 200069656

PubMed Similar studies SRA Run Selector

Select item 2000761982.

Cell type-specific alternative splicing of cytoskeletal domains governs cell fate in the developing cerebral cortex

(Submitter supplied) Alternative splicing regulates over 90% of multiexon mammlian genes, but its role in specifying neural progenitor cell (NPC) fates has not been explored. Our analyses of purified mouse NPCs and neurons from developing cerebral cortices revealed hundreds of conserved and differentially spliced exons that add or remove key protein domains, especially in genes regulating the cytoskeleton.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
4 Samples

Download data: FPKM_TRACKING

Series

Accession:: GSE76198

ID:: 200076198

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000655423.

The PTBP1-associated long noncoding RNA Pnky regulates embryonic and postnatal neural stem cells

(Submitter supplied) While thousands of long noncoding RNAs (lncRNAs) have been identified, few lncRNAs that control neural stem cell (NSC) behavior are known. Here, we identify Pinky (Pnky) as a novel, neural-specific lncRNA that regulates neurogenesis from NSCs in the embryonic and postnatal brain. In postnatal NSCs, Pnky knockdown potentiates neuronal lineage commitment and expands the transit-amplifying cell population, increasing neuron production several-fold. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: DIFF, TXT

Series

Accession:: GSE65542

ID:: 200065542

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000379334.

Coordinated regulation of neuronal mRNA steady-state levels through developmentally controlled intron retention

(Submitter supplied) Differentiated cells acquire unique structural and functional traits through coordinated expression of lineage-specific genes. An extensive battery of genes encoding components of the synaptic transmission machinery and specialized cytoskeletal proteins is activated during neurogenesis, but the underlying regulation is not well understood. Here we show that genes encoding critical presynaptic proteins are transcribed at a detectable level in both neurons and non-neuronal cells. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11002
3 Samples

Download data: TSV

Series

Accession:: GSE37933

ID:: 200037933

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000475675.

Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Other; Expression profiling by array

Platforms:: GPL6193 GPL11002 GPL8940
22 Samples

Download data: CEL

Series

Accession:: GSE47567

ID:: 200047567

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000475666.

Wild type vs. Ptbp2 KO mouse embryonic cortex RNA

(Submitter supplied) To assess the requirement of Ptbp2 for alternative processing of RNA in mouse brain

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL8940
6 Samples

Download data: CEL

Series

Accession:: GSE47566

ID:: 200047566

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000475657.

Wild type vs. Ptbp2 KO mouse E18.5 cortex RNA

(Submitter supplied) To assess the requirement of Ptbp2 for alternative mRNA expression in mouse brain

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6193
8 Samples

Download data: CEL

Series

Accession:: GSE47565

ID:: 200047565

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000475648.

Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain [HITS-CLIP]

(Submitter supplied) Two polypyrimidine tract RNA-binding proteins (PTBs), one near-ubiquitously expressed (Ptbp1) and another highly tissue-restricted (Ptbp2), regulate RNA in interrelated but incompletely understood ways. Ptbp1, a splicing regulator, is replaced in the brain and differentiated neuronal cell lines by Ptbp2. To define the roles of Ptbp2 in the nervous system, we generated two independent Ptbp2-null strains, unexpectedly revealing that Ptbp2 is expressed in neuronal progenitors and is essential for postnatal survival. more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL11002
8 Samples

Download data: BED, WIG

Series

Accession:: GSE47564

ID:: 200047564

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000851659.

Identification of PTBPs RNA binding sites in mouse brain

(Submitter supplied) PTBP1 and PTBP2 are RNA-binding proteins that control RNA processings, including alternative pre-mRNA splicing. The sequential down-regulation of the two proteins is necessary for neuronal maturation. However, their binding substrates in neural tissues have not been examined.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
6 Samples

Download data: GFF

Series

Accession:: GSE85165

ID:: 200085165

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20008480310.

Transcriptome of the mouse neocortices

(Submitter supplied) Derive alternative splicing regulatory networks of PTBP1 and PTBP2

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
7 Samples

Download data: XLSX

Series

Accession:: GSE84803

ID:: 200084803

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20024137911.

Alternative splicing of a chromatin modifier alters the transcriptional regulatory programs of embryonic stem cell maintenance and neuronal differentiation [ChIP-seq]

(Submitter supplied) Maintenance of embryonic stem cells (ESCs) and their differentiation to neuronal lineages requires complex genetic regulation of transcription, splicing, and translation, but the interconnections of these processes is not well understood. We found that the splicing regulator polypyrimidine tract binding protein 1 (PTBP1) alters the neuronal transcriptional program. Transcripts for DPF2, a subunit of the BRG1/BRM-associated factor (BAF) chromatin remodeling complex, contain an additional exon (exon 7) in brain. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21493
20 Samples

Download data: BW

Series

Accession:: GSE241379

ID:: 200241379

PubMed Similar studies

Select item 20024137812.

Alternative splicing of a chromatin modifier alters the transcriptional regulatory programs of embryonic stem cell maintenance and neuronal differentiation.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL24247 GPL21493
36 Samples

Download data

Series

Accession:: GSE241378

ID:: 200241378

PubMed Similar studies

Select item 20024137713.

Alternative splicing of a chromatin modifier alters the transcriptional regulatory programs of embryonic stem cell maintenance and neuronal differentiation [RNA-seq]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
18 Samples

Download data: TXT

Series

Accession:: GSE241377

ID:: 200241377

PubMed Similar studies

Select item 20024137614.

Alternative splicing of a chromatin modifier alters the transcriptional regulatory programs of embryonic stem cell maintenance and neuronal differentiation[ATAC-seq]

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21493
18 Samples

Download data: BW

Series

Accession:: GSE241376

ID:: 200241376

PubMed Similar studies

Select item 20000849815.

The MicroRNA miR-124 Promotes Neuronal Differentiation by Triggering Brain-Specific Alternative Pre-mRNA Splicing

(Submitter supplied) Both microRNAs and alternative pre-mRNA splicing have been implicated in the development of the nervous system (NS), but functional interactions between these two pathways are poorly understood. We demonstrate that the neuron-specific microRNA miR-124a directly targets PTBP1/PTB/hnRNPI mRNA, which encodes a global repressor of alternative pre-mRNA splicing in non-neuronal cells. Among the targets of PTBP1 is a critical cassette exon in the pre-mRNA of PTBP2/nPTB/brPTB, an NS-enriched PTBP1 homolog. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2846
Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE8498

ID:: 200008498

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 284616.

MicroRNA miR-124 expression effect on neuronal cell line

Analysis of neuroblastoma CAD cells expressing neuron-specific microRNA miR-124. MicroRNAs have been implicated in the development of the nervous system (NS). Results provide insight into the function of miR-124 in neuronal cells.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 protocol sets

Platform:: GPL1261
Series:: GSE8498
6 Samples

Download data: CEL

DataSet

Accession:: GDS2846

ID:: 2846

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20005727817.

A global regulatory mechanism for activating an exon network required for neurogenesis

(Submitter supplied) The vertebrate and neural-specific SR-related protein nSR100/SRRM4 regulates an extensive program of alternative splicing with critical roles in nervous system development. However, the mechanism by which nSR100 controls its target exons is poorly understood. We demonstrate that nSR100-dependent neural exons are associated with a unique configuration of intronic cis-elements that promote rapid switch-like regulation during neurogenesis. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL16791 GPL11154 GPL17021
22 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE57278

ID:: 200057278

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007117918.

The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL13112
30 Samples

Download data: BED, TXT

Series

Accession:: GSE71179

ID:: 200071179

PubMed Full text in PMC Similar studies

Select item 20007117819.

Ptpb1 iCLIP in 46C mESCs and mNPCs

(Submitter supplied) PTBP1 and PTBP2 control alternative splicing programs during neuronal development, but the cellular functions of most PTBP1/2-regulated isoforms remain unknown. We show that PTBP1 guides developmental gene expression by regulating the transcription factor Pbx1. We identify exons that are differentially spliced when mouse embryonic stem cells (ESCs) differentiate into neuronal progenitor cells (NPCs) and neurons, and transition from PTBP1 to PTBP2 expression. more...