Similar studies for GEO DataSets (Select 200065075) - GEO DataSets

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Items: 3

Select item 2000650751.

Acute lung injury results from innate sensing of viruses by an ER stress pathway

(Submitter supplied) Incursions of new pathogenic viruses into humans from animal reservoirs are occurring with alarming frequency. The molecular underpinnings of immune recognition, host responses, and pathogenesis in this setting arepoorly understood. We studied pandemic influenza viruses to determine the mechanism by which increasing glycosylation during evolution of surface proteins facilitates diminished pathogenicity in adapted viruses. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
20 Samples

Download data: CEL

Series

Accession:: GSE65075

ID:: 200065075

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000892462.

Glycosylation of the HA protein of H5N1 virus increases its virulence in mice by exacerbating the host immune response

(Submitter supplied) The highly pathogenic avian influenza (HPAI) H5N1 viruses continue to circulate in nature and threaten public health. Although several viral determinants and host factors that influence the virulence of HPAI H5N1 viruses in mammals have been identified, the detailed molecular mechanism remains poorly defined and requires further clarification. In our previous studies, we characterized two naturally isolated HPAI H5N1 viruses that had similar viral genomes but differed substantially in their lethality in mice. more...