Similar studies for GEO DataSets (Select 200048977) - GEO DataSets

Select item 2000489771.

A systems biology approach to understand the pathophysiological mechanisms of cardiac pathological hypertrophy associated with rosiglitazone

(Submitter supplied) Cardiac pathological hypertrophy is associated with a significantly increased risk of coronary heart disease and has been observed in diabetic patients treated with rosiglitazone, whereas most published studies do not suggest a similar increase in risk of cardiovascular events in pioglitazone-treated diabetic subjects. This study sought to understand the pathophysiological mechanisms underlying the disparate cardiovascular effects of rosiglitazone and pioglitazone and yield knowledge as to the causative nature of rosiglitazone-associated cardiac hypertrophy.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
16 Samples

Download data: TXT

Series

Accession:: GSE48977

ID:: 200048977

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000368752.

Transcriptome Alteration in the Diabetic Heart by Rosiglitazone: Implications for Cardiovascular Mortality

(Submitter supplied) The type 2 diabetes medication, rosiglitazone, has come under scrutiny for possibly increasing the risk of cardiac disease and death. To investigate the effects of rosiglitazone on the diabetic heart, we performed cardiac transcriptional profiling of a murine model of type 2 diabetes, the C57BL/KLS-leprdb/leprdb (db/db) mouse. We compared cardiac gene expression profiles from three groups: untreated db/db mice (db-c), db/db mice after rosiglitazone treatment (db-t), and non-diabetic db/+ mice.

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4990
Platform:: GPL4134
15 Samples

Download data: TXT

Series

Accession:: GSE36875

ID:: 200036875

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 49903.

Diabetic db/db heart response to rosiglitazone

Analysis of hearts from obese diabetic C57BL/KsJ-db/db mice following treatment with rosiglitazone, a medication for type 2 diabetes. Results provide insight into the molecular basis of the cardiac decompensation associated with both diabetes and rosiglitazone treatment.

Organism:: Mus musculus

Type:: Expression profiling by array, log10 ratio, 2 agent, 2 genotype/variation sets

Platform:: GPL4134
Series:: GSE36875
15 Samples

Download data: TXT

DataSet

Accession:: GDS4990

ID:: 4990

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000678904.

Expression data from Bama minipig hearts - high-fat, high-sucrose diet

(Submitter supplied) In order to study the heart disorder that the long term, high energy diet caused, Bama miniature pigs were fed a high-fat, high-sucrose diet for 23 months. These pigs developed symptoms of metabolic syndrome and showed cardiac steatosis and hypertrophy with a greatly increased heart weight (1.82-fold, P<0.05) and heart volume (1.60-fold, P<0.05) compared with the control pigs. To understand the molecular mechanisms of cardiac steatosis and hypertrophy, nine pig heart cRNA samples were hybridized to porcine GeneChips.

Organism:: Sus scrofa

Type:: Expression profiling by array

Platform:: GPL3533
9 Samples

Download data: CEL, CHP, TXT

Series

Accession:: GSE67890

ID:: 200067890

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000123375.

Transcriptomic analysis of PPARalpha-dependent alterations during cardiac hypertrophy

(Submitter supplied) Findings suggest that PPARalpha plays a decisive role in the development of hypertrophy, affecting the functional outcome of the heart. Unfortunately, information on the nature of PPARalpha-dependent processes in cardiac hypertrophy is fragmentary and incomplete. The primary aim of this study was to identify the processes and signaling pathways regulated by PPARalpha in hearts challenged by a chronic pressure overload by means of whole genome transcriptomic analysis. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3465
Platform:: GPL1261
16 Samples

Download data: CEL

Series

Accession:: GSE12337

ID:: 200012337

Select item 34656.

PPARalpha deficient heart response to chronic pressure overload

Analysis of heart left ventricles subjected to chronic pressure overload for 28 days to induce cardiac hypertrophy. PPARalpha mitigates cardiac hypertrophy. Results provide insight into processes and signalling pathways regulated by PPARalpha in hearts challenged by chronic pressure overload.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 genotype/variation, 2 stress sets

Platform:: GPL1261
Series:: GSE12337
16 Samples

Download data: CEL

DataSet

Accession:: GDS3465

ID:: 3465

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