Similar studies for GEO DataSets (Select 200022535) - GEO DataSets

Select item 2000225351.

Expression data from mouse liver on multisetp-exposure to ethylbenzene

(Submitter supplied) The processes involved in the adaptation of animals to environmental factors such as chemicals have not yet been fully elucidated. We focused on the adaptive potential of the mouse liver against hepatotoxic chemical-induced injury. We used microarrays to determine genes with adaptive transcriptional regulation against ethylbenzene, hepatotoxic chemical, on multistep-exposure.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
4 Samples

Download data: CEL

Series

Accession:: GSE22535

ID:: 200022535

Select item 2000225342.

Expression data from PDK4 overexpressing (Ad-PDK4 infected) and control (Ad-control infected) mouse liver

(Submitter supplied) We identified PDK4 as a gene with adaptive transcriptional response to chemical stress. Although PDK4 is an energy resource regulator induced by starvation, expression of other fasting-inducible genes was unaffected, indicating additional physiological role of PDK4 for liver adaptation to the chemical stress. We used microarrays to determine genes with altered transcriptional level by PDK4 overexpression.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
2 Samples

Download data: CEL

Series

Accession:: GSE22534

ID:: 200022534

Select item 2000038663.

p38 MAPK overexpression in heart in vivo.

(Submitter supplied) Mitogen-activated protein kinases (MAPKs) regulate cardiomyocyte growth and apoptosis in response to extracellular stimulation, but the downstream effectors that mediate their pathophysiological effects remain poorly understood. We determined the targets and role of p38 MAPK in the heart in vivo by using local adenovirus-mediated gene transfer of constitutively active upstream kinase mitogen-activated protein kinase kinase 3b (MKK3bE) and wild-type p38α in rats. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS2487
Platform:: GPL1355
10 Samples

Download data: CEL, EXP

Series

Accession:: GSE3866

ID:: 200003866

Select item 24874.

p38 mitogen-activated protein kinase overexpression effect on the heart

Analysis of left heart ventricles of transgenics overexpressing the mitogen-activated protein kinase (MAPK) p38 in their hearts. p38 is involved in the pathophysiology of inflammatory diseases. Results provide insight into the role of p38 in the heart.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 protocol sets

Platform:: GPL1355
Series:: GSE3866
10 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS2487

ID:: 2487

Select item 2000040865.

Hypoxia responsive genes in human Burkitt’s lymphoma cell line, P493-6.

(Submitter supplied) Activation of glycolytic genes by HIF-1 is considered critical for metabolic adaptation to hypoxia. We found that HIF-1 also actively suppresses glucose metabolism through the tricarboxylic acid cycle (TCA) by directly trans-activating the gene encoding pyruvate dehydrogenase kinase 1 (PDK1). PDK1 inactivates the TCA cycle enzyme, pyruvate dehydrogenase (PDH), which converts pyruvate to acetyl-CoA. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS1807
Platform:: GPL570
4 Samples

Download data: CEL, EXP

Series

Accession:: GSE4086

ID:: 200004086

Select item 18076.

Hypoxia effect on B lymphocyte cell line

Expression profiling of B lymphocyte P493-6 cells subjected to hypoxia. Cells incubated in 0.1% oxygen for 29 hours, the point of highest expression of hypoxia-inducible factor 1 (HIF-1). Results identify hypoxia responsive genes in P493-6 cells.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 stress sets

Platform:: GPL570
Series:: GSE4086
4 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS1807

ID:: 1807

Select item 2002130807.

Cardiomyocyte Pdk4 response is associated with metabolic maladaptation in aging

(Submitter supplied) Pyruvate Dehydrogenase Kinase 4 (Pdk4) is a pyruvate dehydrogenase inhibiton gene that strongly regulates metabolism. We studied the expression of Pdk4 in the young and aged mouse heart in both healthy conditions and after ischemic insult.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
4 Samples

Download data: MTX, TSV

Series

Accession:: GSE213080

ID:: 200213080

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