GEO DataSets

(Submitter supplied) Curcumin, a yellow pigment extracted from the rhizome of the plant Curcuma longa (turmeric) has been widely used as a spice and herbal medicine in Asia. It has been suggested to have many biological activities such as anti-oxidative, anti-inflammatory, anti-cancer, chemopreventive, and anti-neurodegenerative properties. We evaluated the impact of curcumin on lifespan, fecundity, feeding rate, oxidative stress, locomotion and gene expression in two different wild type Drosophila melanogaster strains, Canton-S and Ives, under two different experimental conditions. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL1322

4 Samples

Download data: CEL

(Submitter supplied) Background. Juvenile hormone (JH) has been demonstrated to control adult lifespan in a number of non-model insects where surgical removal of the corpora allata eliminates the hormone’s source. In contrast, little is known about how juvenile hormone affects adult Drosophila melanogaster. Previous work suggests that insulin signaling may modulate Drosophila aging in part through its impact on juvenile hormone titer, but no data yet addresses whether reduction of juvenile hormone is sufficient to control Drosophila life span. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL1322

12 Samples

Download data: CEL

(Submitter supplied) The mechanisms underlying natural variation in lifespan and ageing rate remain largely unknown. We performed microarray experiment to characterise genome-wide expression patterns of a long-lived, natural variant of Drosophila melanogaster resulting from selection for starvation resistance (SR) and compare it with normal-lived control flies (C).

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL1322

46 Samples

Download data: CEL

(Submitter supplied) The expression profiles of Drosophila Kc167 and SL2 cells were compared on the CDMC_Drosophila_7k2 array platform. Three independent RNA samples from each cell line were isolated and compared in a pairwise fashion. Dye-flip experiments were also performed. See Neal et al. 2003 for results and discussion. Keywords = Kc167 Keywords = SL2 Keywords = Drosophila Keywords: other

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL311

6 Samples

Download data: TIFF

(Submitter supplied) A large batch of Drosophila Kc167 total RNA was prepared and was used for 3 homotypic hybridizations in order to evaluate the inter-slide variability using the CDMC_Drosophila_7k2 platform. See Neal et al. 2003 for results and discussion. Keywords = Kc167 Keywords = Drosophila Keywords = Platform Variability Keywords: other

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL311

3 Samples

Download data: TIFF

(Submitter supplied) Three different amounts, 20 ug (GSM6155), 40 ug (GSM6157) and 80ug (GSM6158), of total Kc167 RNA were used in homotypic labelings to determine the optimal amount of RNA necesary to produce the most useable data using the CDMC_Drosophila_7k2 array. See Neal et al. 2003 for results and discussion. Keywords = Kc167 Keywords = Drosophila Keywords = RNA amount Keywords: other

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Dataset:

GDS374

Platform:

GPL311

3 Samples

Download data: TIFF

(Submitter supplied) The CDMC_Drosophila_7K2 array is a primarily cDNA-based Drosophila melanogaster glass microarray. The array features 5,756 Berkeley Drosophila Genome Project cDNAs, 1,078 NIH Testis cDNAs (Andrews et al. 2000) and 546 gene fragments that were amplified from genomic DNA, together representing approximately 50% of the predicted genes in D. melanogaster. The array is produced by the Canadian Drosophila Microarray Centre at the University of Toronto and is available for distribution to academic labs. more...

Organism:

Drosophila melanogaster

1 DataSet

5 Series

19 Samples

Download data

Analysis of the effect of varying starting quantity of RNA. Three different amounts, 20 ug, 40 ug and 80 ug total Kc167 RNA used in homotypic labelings to determine optimal quantity of RNA.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array, log ratio, 3 protocol sets

Platform:

GPL311

Series:

GSE417

3 Samples

Download data: TIFF

(Submitter supplied) The aim of this study was to use unbiased transcriptomic analysis to characterize new traits that may explain differences in longevity between short- and long-lived wild-type backgrounds of Drosophila melanogaster – Dahomey and Oregon R, respectively. For the experiment we chose young flies (10 days old) to capture the difference in basal gene expression related to the genotype rather than to age-dependent functional decline. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17275

8 Samples

Download data: XLS

(Submitter supplied) Illumina sequencing was used to assay the effect of mifepristone treatment on gene expression in adult Drosophila, including males, virgin females and mated females.

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17275

18 Samples

Download data: DIFF

(Submitter supplied) Transposable elements (TE) are mobile sequences of DNA that can become transcriptionally active as an animal ages. Activation of the stress response transcription factor FOXO can increase longevity in flies and worms. Research into the subject has centered on metabolism as the driver of aging. Whether TE activity is a byproduct of heterochromatin breakdown or can contribute towards the aging process is not known. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19132

12 Samples

Download data: CSV

(Submitter supplied) ABSTRACT MAGWIRE, MICHAEL MAHLON. Mutations Increasing Drosophila melanogaster Life Span. (Under the direction of Trudy F. C. Mackay.) Better living conditions and advances in medicine have made it possible for humans to live considerably longer than before. This has uncovered many health problems associated with age. By identifying genes involved in the limitation of life span, we may better understand the processes that lead to aging. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL1322

32 Samples

Download data: CEL, CHP

(Submitter supplied) One of the critical substances that mammals highly regulate via the respiratory, cardiovascular and neurologic systems is O2. Both low and high O2 levels can induce major morbidities as well as mortality. Indeed, O2 has been often considered as both an elixir and a poison in humans. In current study, we have used an experimental selection approach to generate Drosophila strains that are tolerant to severe hyperoxic environment. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL1322

24 Samples

Download data: CEL

(Submitter supplied) We have recently developed a Drosophila behavioral- and transcriptomic- based (systems) model of chronic pentylenetetrazole (PTZ) induced locomotor plasticity. Pharmacological validation using antiepileptic drugs (AEDs) shows that the model is predictive of antiepileptic, antiepileptogenic, disease-modifying and neuroprotective activities. This model is however developed using male flies. The present submission relates to microarray gene expression profiling of fly heads after treatment of female Drosophila adults with PTZ for seven days subsequent withdrawal of PTZ for next seven days. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL1467

16 Samples

Download data: GPR

(Submitter supplied) To determine how dietary BCAAs modulate transcriptional networks in the brain, we designed three diets of varying BCAA concentrations (low BCAA, reference diet, and high BCAA). We performed transcriptional profiling of brains using RNA-seq after flies had been on one of three BCAA diets for one week.

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19132

24 Samples

Download data: TXT

(Submitter supplied) Two cages of 12,000 once mated females were used. Samples were collected starting on Day 2 in the box, followed by days 9, 16, 23, 30, 37, 44, 51, 58, 65, 72, and 79 in the boxes. The gene-expression profiles were computed over the lifespan of these females.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL19987

66 Samples

Download data: GPR