Similar studies for GEO DataSets (Select 200015241) - GEO DataSets

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Items: 10

Select item 2000152411.

Drug-inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites

(Submitter supplied) Plasmodium and Toxoplasma are parasites of major medical importance that belong to the Apicomplexa phylum of protozoa. These parasites transform into various stages during their life cycle and express a specific set of proteins at each stage. Although still little is known of how gene expression is controlled in Apicomplexa, histone modifications, particularly acetylation, are emerging as key regulators of parasite differentiation and stage conversion. more...

Organism:: Toxoplasma gondii ME49; Toxoplasma gondii

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL8305
2 Samples

Download data: PAIR

Series

Accession:: GSE15241

ID:: 200015241

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000072622.

Epigenomic modifications predict active promoters and gene structure in Toxoplasma gondii

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Toxoplasma gondii; Toxoplasma gondii RH

Type:: Expression profiling by genome tiling array; Genome binding/occupancy profiling by genome tiling array

Platform:: GPL4397
17 Samples

Download data: TXT

Series

Accession:: GSE7262

ID:: 200007262

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000059923.

ChIP on chip "Epigenomic modifications predict active promoters and gene structure in Toxoplasma gondii"

(Submitter supplied) ChIP on chip with modified histones antibodies Keywords: ChIP-chip

Organism:: Toxoplasma gondii; Toxoplasma gondii RH

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL4397
14 Samples

Download data: TXT

Series

Accession:: GSE5992

ID:: 200005992

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000059894.

Gene expression "Epigenomic modifications predict active promoters and gene structure in Toxoplasma gondii"

(Submitter supplied) total RNA was extracted after 24 hours of development of the RH strain in HFF cells. Keywords: gene expression

Organism:: Homo sapiens; Toxoplasma gondii; Toxoplasma gondii RH

Type:: Expression profiling by array; Expression profiling by genome tiling array

Platform:: GPL4397
3 Samples

Download data: TXT

Series

Accession:: GSE5989

ID:: 200005989

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001759195.

A potent HDAC inhibitor blocks Toxoplasma gondii tachyzoite growth and profoundly disrupts parasite gene expression.

(Submitter supplied) Toxoplasmosis is a major health issue worldwide especially for immune-deficient individuals and the offspring of newly infected mothers. It is caused by a unicellular intracellular parasite called Toxoplasma gondii. Although the drugs commonly used to treat toxoplasmosis are efficient, they present serious side effects and adverse events are common. Therefore, there is a need for the discovery of new compounds with potent anti-T. more...

Organism:: Toxoplasma gondii

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23377
6 Samples

Download data: XLSX

Series

Accession:: GSE175919

ID:: 200175919

PubMed Similar studies SRA Run Selector

Select item 2000904786.

Histone deacetylase inhibitor MS-275 augments expression of a subset of IFN-γ-regulated genes in Toxoplasma gondii-infected macrophages but does not improve parasite control

(Submitter supplied) Toxoplasma gondii is a ubiquitous apicomplexan parasite of mammals and birds and an important pathogen of humans. IFN-g is the major mediator of host resistance against T. gondii but intriguingly, parasite-infected host cells including macrophages are severely impaired to respond to IFN-g due to defective transcriptional activation of target genes. Here, we tested the possibility that the impaired responsiveness of T. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
10 Samples

Download data: CSV

Series

Accession:: GSE90478

ID:: 200090478

PubMed Similar studies SRA Run Selector

Select item 2001361237.

A MORC-driven transcriptional switch controls Toxoplasma developmental trajectories and sexual commitment

(Submitter supplied) Purpose: T. gondii has a complex life cycle typified by an asexual development taking place in vertebrate and a sexual reproduction occurring exclusively in felids and thereby is less studied. The developmental transitions rely on changes in gene expression patterns, and recent studies have assigned roles for chromatin shapers, including histone modifications, in establishing specific programs for a given stage. more...

Organism:: Toxoplasma gondii

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23377
18 Samples

Download data: XLSX

Series

Accession:: GSE136123

ID:: 200136123

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001360608.

A MORC-driven transcriptional switch controls Toxoplasma developmental trajectories and sexual commitment

(Submitter supplied) Toxoplasma gondii has a complex life cycle that is typified by asexual development that takes place in vertebrates, and sexual reproduction, which occurs exclusively in felids and is therefore less studied. The developmental transitions rely on changes in the patterns of gene expression, and recent studies have assigned roles for chromatin shapers, including histone modifications, in establishing specific epigenetic programs for each given stage. more...

Organism:: Toxoplasma gondii

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL23466
12 Samples

Download data: BED, WIG

Series

Accession:: GSE136060

ID:: 200136060

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001340999.

Temporal analysis of in vivo Toxoplasma gondii cysts shows novel and late stage specific transcripts.

(Submitter supplied) The protozoan pathogen Toxoplasma gondii has the unique ability to develop a chronic infection in the brain of its host. The T. gondii develops cysts within the neurons that are resilient against the host immune response and current therapeutics. The bradyzoite parasites within the cyst have a sugar-protein-rich wall and a slow-replication cycle, allowing them to remain hidden from the host. This intracellular encysted lifestyle of T. more...

Organism:: Toxoplasma gondii

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23377
6 Samples

Download data: GTF, TXT

Series

Accession:: GSE134099

ID:: 200134099

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20019800110.

Double RNA-seq analysis of Calmodulin indirect knockout in Toxoplasma gondii TATI strain

(Submitter supplied) Toxoplasma gondii is an apicomplexan parasite infecting human and animals, causing huge health concerns and economic losses. Calcium ion, a critical second messenger in cells, can regulate related vital activities, particularly in parasite invasion and escape processes. Calmodulin (CaM) is a short, highly conserved Ca2+ binding protein found in all eukaryotic cells, including apicomplexan parasites. more...