GEO DataSets

(Submitter supplied) Comparison of expression profiles of primary colorectal cancers with liver metastases of the same patient. Additionally, expression data of normal colon and liver tissue. Abstract of publication will be included upon publication Keywords: expression profiling, colorectal cancer, colon cancer, liver metastasis, normal colonic tissue, normal liver tissue

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6370

48 Samples

Download data: TIFF, TXT

(Submitter supplied) Comparison of genomic alterations of primary colorectal cancers with liver metastases of the same patient Keywords: array CGH, colorectal cancer, colon cancer, liver metastasis

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platform:

GPL6365

42 Samples

Download data: GPR

(Submitter supplied) The small intestinal epithelium is the most rapidly self-renewing tissue of mammals. Proliferative cells are confined to crypts, while differentiated cell types predominantly occupy the villi. We recently demonstrated the existence of a long-lived pool of cycling stem cells defined by Lgr5 expression and intermingled with post-mitotic Paneth cells at crypt bottoms. We have now determined a gene signature for these so called Crypt Base Columnar (CBC) cells. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4134

8 Samples

Download data: TXT

(Submitter supplied) Chromosomal instability (CIN) is the hallmark of colorectal adenoma to carcinoma progression in 85% of cases, with 20q gain as the most prominent aberration. Yet, the oncogenes at this chromosomal gain are still largely unknown. Here, we aimed to identify oncogenes at 20q involved in colorectal adenoma to carcinoma progression by measuring the effect of 20q gain on gene expression in this amplicon. more...

Organism:

Homo sapiens

Type:

Expression profiling by array; Genome variation profiling by genome tiling array

5 related Platforms

217 Samples

Download data

(Submitter supplied) Accurate staging of colorectal cancer (CRC) with clinicopathological parameters is important for predicting prognosis and guiding treatment but provides us no information about organ site of metastases. Patterns of genomic aberrations in primary colorectal tumors may reveal a chromosomal signature for organ specific metastases.

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platform:

GPL4560

98 Samples

Download data: TXT

(Submitter supplied) We have performed gene expression profiling of surgically resected liver metastases by exon-resolution microarrays, and identified a metastasis-oriented subtyping framework consisting of 5 de novo transcriptomic subtypes (LMS1-5).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17586

283 Samples

Download data: CEL, CHP

(Submitter supplied) At present, medical treatments of synchronous and metachronous liver metastases from colorectal cancer are not differentiated. The aim of the study was to analyze the gene expression profiling of synchronous and metachronous lesions in order to identify molecular signatures as possible basis for choice of systemic therapies. Fresh tissues specimens from metastases of 18 patients undergone liver surgery were collected (10 synchronous and 8 metachronous lesions). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3501

Platform:

GPL570

18 Samples

Download data: CEL, CHP

Analysis of synchronous and metachronous liver metastatic lesions from colorectal cancer (CC). The liver is a common site of metastases from CC. Synchronous metastatic lesions arise less than 6 months after the resection of the primary tumor, metachronous lesions arise 6 months after resection.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL570

Series:

GSE10961

18 Samples

Download data: CEL, CHP

(Submitter supplied) Genomic profiling of primary colorectal carcinomas was performed in relation to the spread of CTCs in peripheral and hepatic venous blood, liver metastases, and distant metastases beyond the liver, with the intent to identify specific patterns for the different stages of metastatic spread.

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array; SNP genotyping by SNP array

Platform:

GPL8887

53 Samples

Download data: IDAT, TXT

(Submitter supplied) The canonical Wnt pathway plays a central role in stem cell maintenance, differentiation and proliferation in the intestinal epithelium. Constitutive, aberrant activity of the TCF4/β-catenin transcriptional complex is the primary transforming factor in colorectal cancer. Despite significant recent inroads, the full complement of Wnt target genes and the mechanisms of regulation remain incompletely understood. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17303

8 Samples

Download data: TXT

(Submitter supplied) Liver metastasis is one of the major causes of death in colorectal cancer (CRC) patients. To understand this process, we investigated whether the gene expression profiling of matched colorectal carcinomas and liver metastases could reveal key molecular events involved in tumor progression and metastasis. We performed experiments using a cDNA microarray containing 17,104 genes with the following tissue samples: paired tissues of 25 normal colorectal mucosa, 27 primary colorectal tumors, 13 normal liver and 27 liver metastasis, and 20 primary colorectal tumors without liver metastasis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4811

123 Samples

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(Submitter supplied) Somatic copy number alterations of 17 paired tumor and metastasis tissue samples were measured by Agilent array-based comparative genomic hybridization (CGH). Seven colon adenocarcinomas with paired liver metastasis and 10 liver carcinoma with metastasis to the lymph node, adrenal gland or lung were analyzed.

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platform:

GPL9075

34 Samples

Download data: TXT

(Submitter supplied) Enriched tumor epithelium from 61 primary and metastasis tumor specimens was obtained by laser capture microdissection (LCM) as previously described (Boersma et al., 2007). In brief, frozen 8-μm serial sections from OCT-preserved frozen tissues were prepared and mounted on plain, uncharged microscope slides. One Hematoxylin/eosin-stained section of each specimen was reviewed by a pathologist to confirm diagnosis and presence of tumor. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

61 Samples

Download data: CEL

(Submitter supplied) Background & Aims: The metastatic process is complex and remains a major obstacle in the management of colorectal cancer (CRC). To gain a better insight into the biologic events driving the metastatic process we investigated genomic aberrations in a large cohort of matched CRC primaries and distant metastases from various sites. Methods: In total, 62 primary colorectal cancers, 62 matched normal specimens, and 68 matched metastases (from liver, lung, ovary, omentum, and distant lymph nodes) were analyzed by high resolution array comparative genomic hybridization (array CGH) for DNA copy number changes. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array; Third-party reanalysis

Platform:

GPL8687

130 Samples

Download data: TXT

(Submitter supplied) Organoid technology provides the possibility to culture human colon tissue and patient-derived colorectal cancers (CRC) while maintaining all functional and phenotypic characteristics. Labeling of human colon stem cells (CoSCs), especially in normal and benign tumor organoids, is challenging and therefore limits usability of multi-patient organoid libraries for CoSC research. Here, we developed STAR (STem cell Ascl2 Reporter), a minimal enhancer/promoter element that reports transcriptional activity of ASCL2, a master regulator of LGR5+ CoSC fate. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11154

18 Samples

Download data: TXT

(Submitter supplied) To identify genes implicated in metastatic colonization of the liver in colorectal cancer, we collected pairs of primary tumors and hepatic metastases before chemotherapy in 13 patients. We compared mRNA expression in the pairs of patients to identify genes deregulated during metastatic evolution. We then validated the identified genes using data obtained by different groups. The 33-gene signature was able to classify 87% of hepatic metastases, 98% of primary tumors, 97% of normal colon mucosa, and 95% of normal liver tissues in six datasets obtained using five different microarray platforms. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL97

57 Samples

Download data: CEL

(Submitter supplied) To identify genes implicated in metastatic colonization of the liver in colorectal cancer, we collected pairs of primary tumors and hepatic metastases before chemotherapy in 13 patients. We compared mRNA expression in the pairs of patients to identify genes deregulated during metastatic evolution. We then validated the identified genes using data obtained by different groups. The 33-gene signature was able to classify 87% of hepatic metastases, 98% of primary tumors, 97% of normal colon mucosa, and 95% of normal liver tissues in six datasets obtained using five different microarray platforms. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

57 Samples

Download data: CEL

(Submitter supplied) Normal human tissue samples from ten post-mortem donors were processed to generate total RNA, which was subsequently analyzed for gene expression using Affymetrix U133 plus 2.0 arrays. Donor information: Donor 1 - 25 year old male; donor 2 - 38 year old male; donor 3 - 39 year old female; donor 4 - 30 year old male; donor 5 - 35 year old male; donor 6 - 52 year old male; donor 7 - 50 year old female; donor 8 - 48 year old female; donor 9 - 53 year old female; donor 10 - 23 year old female Keywords: normal human tissue comparison

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

353 Samples

Download data: CEL

(Submitter supplied) To develop a classifier based on microRNAs for primary tumor site identification of liver core biopsies and to explore the influence of surrounding normal liver tissue on classification.

Organism:

Homo sapiens

Type:

Expression profiling by RT-PCR

Platform:

GPL17391

333 Samples

Download data: TXT