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Links from GEO DataSets

Items: 20

1.

Gene expression profile of Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP)

(Submitter supplied) Gene expression profile of Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) reveals murine targets for preclinical development of human prostate cancer therapy In this study, we have generated an open source TRAMP microarray dataset to identify differentially expressed genes from human prostate cancer that have concordant expression in TRAMP tumors, and thereby represent lead targets for preclinical therapy development. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
18 Samples
Download data: CEL
Series
Accession:
GSE10525
ID:
200010525
2.

caArray_green-00001: Alterations in Gene Expression Profiles during Prostate Cancer Progression

(Submitter supplied) To identify molecular changes that occur during prostate tumor progression, we have characterized a series of prostate cancer cell lines isolated at different stages of tumorigenesis from C3(1)/Tag transgenic mice.
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by array
Platform:
GPL20562
19 Samples
Download data: GPR
Series
Accession:
GSE69892
ID:
200069892
3.

Gene expression profiling of prostate cancer

(Submitter supplied) To better understand the molecular mechanism that underlay tumorigenesis and progression of prostate cancer (PCa), we studied the gene expression profiles of sixteen PCa compared to their matched normal tissues. Using Significance Analysis of Microarrays, we identified 53 genes differentially expressed that were more than 2 fold up- or down-regulated in at least 50 % of the tumors. Keywords: disease state analysis
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL1998
16 Samples
Download data: GPR
Series
Accession:
GSE9347
ID:
200009347
4.

Expression profiling of the mouse prostate after castration and hormone replacement

(Submitter supplied) In this study, we used microarray analysis to determine gene expression profile changes in the mouse prostate following castration and hormone replacement. We first identified genes with significant expression changes in each of these two processes and then generated a list of androgen responsive genes and a list of genes whose expression were inversely correlated with the presence of androgen. The analysis of this data set is described in Wang et al., Differentiation, 2006 Keywords: Time course
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2562
Platform:
GPL81
20 Samples
Download data: CEL
Series
Accession:
GSE5901
ID:
200005901
5.
Full record GDS2562

Prostate response to castration and subsequent hormone replacement

Analysis of prostate of animals following castration and subsequent hormone replacement with testosterone. Castration induces prostate involution, while hormone replacement induces regeneration. Results provide insight into the molecular mechanisms regulating prostatic involution and regeneration.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 protocol sets
Platform:
GPL81
Series:
GSE5901
20 Samples
Download data: CEL
DataSet
Accession:
GDS2562
ID:
2562
6.

Molecular Features of Hormone-Refractory Prostate Cancer Cells by Genome-wide Gene-expression Profiles

(Submitter supplied) To characterize the molecular features of clinical (Hormone-Refractory Prostate Cancers) HRPCs, we generated the precise gene-expression profiles of 25 clinical HRPCs and 10 hormone-sensitive prostate cancers (HSPCs) by genome-wide cDNA microarrays combining with laser microbeam microdisection. Keywords: disease status analysis
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4747
35 Samples
Download data: TXT
Series
Accession:
GSE6811
ID:
200006811
7.

Exon-based clustering of tumor transcriptomes reveals alternative exons associated with metastasis in breast cancer

(Submitter supplied) Exonic profiling is an emerging topic in disease-associated transcriptome analysis, but is still facing major limitations. In this study, we performed a microarray-based analysis of the transcriptome at the exon level of mouse primary mammary tumors having different abilities to give rise to metastases. First, we developed a bioinformatics platform and used a stringent algorithm to identify 679 genes with differentially expressed exons in primary tumors of the 4T1 mouse model of mammary tumor progression. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6193
12 Samples
Download data: CEL
Series
Accession:
GSE19086
ID:
200019086
8.

Expression Changes Relevant for Apoptosis in K562 Cells Co-Treated with Amifostine and Imatinib

(Submitter supplied) We had previously demonstrated an increased proapoptotic effect of Imatinib (STI571) in combination with Amifostine (AMI) in K562 cell line. In this study we used genomic scale gene expression profiling to monitor changes at transcriptional level in K562 cells during the treatment with AMI+STI571. We identified a transcriptional repressor of survival genes, known as BTF, which triggers a pro-apoptotic signal, potentially helpful to overcome the resistance to STI571. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL2829
4 Samples
Download data
Series
Accession:
GSE3312
ID:
200003312
9.

Comparative study of gene expression in human colorectal cancer tissues and normal mucosa

(Submitter supplied) The purpose of our study was to better understand the genetic mechanism of oncogenesis for human colorectal cancer and to identify potential new tumour markers of use in clinical practice. Results: Comparing cancerous tissues with normal colonic mucosa we identified 584 known genes (3%) differentially expressed to a significant degree (p<0.001). Many of the transcripts that were more abundant in tumours than in non-neoplastic tissues appear to reflect important events for colon carcinogenesis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL2829
24 Samples
Download data
Series
Accession:
GSE3294
ID:
200003294
10.

Mat-Lylu cell line compared to G cell line

(Submitter supplied) we analyzed the gene expression profiles of Mat-Lylu cell lines (in duplicate) compared to G cell lines (in duplicate) using Affymetrix tools and dChip software. The objective was to find metastasis-associated genes in prostate cancer, using this in vitro model. Keywords: cell line comparison
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL85
4 Samples
Download data: CEL
Series
Accession:
GSE7703
ID:
200007703
11.

Microarray Analysis of Retinal Gene Expression in the DBA/2J Model of Glaucoma

(Submitter supplied) Purpose: The DBA/2J mouse is a model for secondary angle-closure glaucoma due to iris atrophy and pigment dispersion, which ultimately leads to increased intraocular pressure (IOP). We sought to correlate changes in retinal gene expression with glaucoma-like pathology by performing microarray analysis of retinal RNA from DBA/2J mice at 3 months before disease onset, and at 8 months, after IOP elevation. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS1728
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE3554
ID:
200003554
12.
Full record GDS1728

DBA/2J model of glaucoma: retina

Analysis of retinas from strain DBA/2J with elevated intraocular pressure (IOP). A model for glaucoma, DBA/2J has mutations that lead to iris atrophy and pigment dispersion. These conditions result in increased IOP. Results provide insight into the molecular changes associated with IOP elevation.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 age, 2 disease state sets
Platform:
GPL1261
Series:
GSE3554
6 Samples
Download data: CEL
DataSet
Accession:
GDS1728
ID:
1728
13.

Genome-wide characterization of gene expression variations and DNA copy number changes in prostate cancer cell lines

(Submitter supplied) Abstract: BACKGROUND: The aim of this study was to characterize gene expression and DNA copy number profiles in androgen sensitive (AS) and androgen insensitive (AI) prostate cancer cell lines on a genome-wide scale. METHODS: Gene expression profiles and DNA copy number changes were examined using DNA microarrays in eight commonly used prostate cancer cell lines. Chromosomal regions with DNA copy number changes were identified using cluster along chromosome (CLAC). more...
Organism:
Homo sapiens
Type:
Expression profiling by array; Genome variation profiling by array
Platforms:
GPL3355 GPL3341
16 Samples
Download data
Series
Accession:
GSE4396
ID:
200004396
14.

DNA copy number changes in prostate cancer cell lines

(Submitter supplied) Abstract: BACKGROUND: The aim of this study was to characterize gene expression and DNA copy number profiles in androgen sensitive (AS) and androgen insensitive (AI) prostate cancer cell lines on a genome-wide scale. METHODS: Gene expression profiles and DNA copy number changes were examined using DNA microarrays in eight commonly used prostate cancer cell lines. Chromosomal regions with DNA copy number changes were identified using cluster along chromosome (CLAC). more...
Organism:
Homo sapiens
Type:
Genome variation profiling by array
Platform:
GPL3355
8 Samples
Download data
Series
Accession:
GSE4017
ID:
200004017
15.

Gene expression variations in prostate cancer cell lines

(Submitter supplied) Abstract: BACKGROUND: The aim of this study was to characterize gene expression and DNA copy number profiles in androgen sensitive (AS) and androgen insensitive (AI) prostate cancer cell lines on a genome-wide scale. METHODS: Gene expression profiles and DNA copy number changes were examined using DNA microarrays in eight commonly used prostate cancer cell lines. Chromosomal regions with DNA copy number changes were identified using cluster along chromosome (CLAC). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1699
Platform:
GPL3341
8 Samples
Download data
Series
Accession:
GSE4016
ID:
200004016
16.
Full record GDS1699

Androgen sensitive and insensitive prostate cancer cell lines: expression profiles

Analysis of androgen sensitive (AS) and insensitive (AI) prostate cancer cell lines. Despite the wide use of these cell lines as model systems, a global genotypic characterization of these cell lines is currently lacking. Results identify differences in gene expression profiles.
Organism:
Homo sapiens
Type:
Expression profiling by array, log2 ratio, 8 cell line, 2 cell type sets
Platform:
GPL3341
Series:
GSE4016
8 Samples
Download data
DataSet
Accession:
GDS1699
ID:
1699
17.

Miscellaneous unmatched samples

(Submitter supplied) unmatched samples
Organism:
Homo sapiens
Type:
Expression profiling by RT-PCR
Platform:
GPL2845
4 Samples
Download data
Series
Accession:
GSE36495
ID:
200036495
18.

Non-small Cell Lung Cancer (qRT-PCR)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by RT-PCR
Platform:
GPL2845
105 Samples
Download data: TXT
Series
Accession:
GSE10939
ID:
200010939
19.

Gene expression differences between matched tumor and normal samples of NSCLC patients (qRT-PCR)

(Submitter supplied) Gene expression differences between between matched tumor and normal samples were analyzed using paired t-test. Keywords: disease state analysis
Organism:
Homo sapiens
Type:
Expression profiling by RT-PCR
Platform:
GPL2845
90 Samples
Download data: TXT
Series
Accession:
GSE10937
ID:
200010937
20.

Gene expression differences between adenocarcinoma and squamous cell carcinoma in human NSCLC (qRT-PCR)

(Submitter supplied) Gene expression differences between the tumor subtypes AC and SCC were analyzed using t-test. Keywords: disease subtype analysis
Organism:
Homo sapiens
Type:
Expression profiling by RT-PCR
Platform:
GPL2845
56 Samples
Download data: TXT
Series
Accession:
GSE10936
ID:
200010936
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