GEO DataSets

(Submitter supplied) Recently, abnormalities in mitochondrial oxidative phosphorylation (OXPHOS) have been implicated in the pathogenesis of skeletal muscle insulin resistance in type 2 diabetes. In the present study, we hypothesized that decreased expression of OXPHOS genes could be of similar importance for insulin resistance in the polycystic ovary syndrome (PCOS). Using the HG-U133 Plus 2.0 expression array from Affymetrix, we analyzed gene expression in skeletal muscle from obese women with PCOS (n=16) and age- and body mass index-matched control women (n=13) metabolically characterized by euglycemic-hyperinsulinemic clamp and indirect calorimetry. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3104

Platform:

GPL570

29 Samples

Download data: CEL

Analysis of vastus lateralis muscles from women with insulin-resistant polycystic ovary syndrome (PCOS). Insulin resistance in skeletal muscles is a risk factor for the development of type 2 diabetes in women with PCOS. Results provide insight into the pathogenesis of insulin resistance in PCOS.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL570

Series:

GSE6798

29 Samples

Download data: CEL

(Submitter supplied) Insulin resistance is a common metabolic abnormality in women with PCOS and leads to an elevated risk of type 2 diabetes. Studies have shown that thiazolidinediones (TZD) improve metabolic disturbances in PCOS patients. We hypothesized that the effect of TZD in PCOS is in part mediated by changes in the transcriptional profile of muscle favoring insulin sensitivity. Using Affymetrix microarrays, we examined the effect of pioglitazone (30 mg/day for 16 weeks) on gene expression in skeletal muscle of 10 obese women with PCOS metabolically characterized by a euglycemic-hyperinsulinemic clamp. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS4132 GDS4133

Platform:

GPL570

43 Samples

Download data: CEL

Analysis of skeletal muscle from obese women with polycystic ovary syndrome (PCOS) and obese, healthy women. Results provide insight into whether pioglitazone ameliorates preexisting abnormalities in PCOS patients.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL570

Series:

GSE8157

23 Samples

Download data: CEL

Analysis of skeletal muscle from obese women with polycystic ovary syndrome (PCOS) before and after thiazolidinedione (TZD) pioglitazone treatment. TZDs improve metabolic disturbances in PCOS patients. Results provide insight into the molecular mechanisms underlying the effect of TZD in PCOS.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL570

Series:

GSE8157

20 Samples

Download data: CEL

(Submitter supplied) This experiment was conducted to identify target genes of the peroxisome proliferator-activated receptor alpha (PPARa) in skeletal muscle of transgenic mice that overexpressed PPARa. The following abstract from the published manuscript describes the major findings of this work. A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes.Finck BN, Bernal-Mizrachi C, Han DH, Coleman T, Sambandam N, LaRiviere LL, Holloszy JO, Semenkovich CF, Kelly DP. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2289

Platform:

GPL339

4 Samples

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Analysis of skeletal muscles of transgenics (trs) overexpressing PPARalpha. Trs overexpressing PPARalpha develop glucose intolerance despite protection from diet-induced obesity. Results provide insight into the role of PPARalpha in the development of insulin-resistant diabetes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL339

Series:

GSE5777

4 Samples

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(Submitter supplied) Gene expression profiles in tissues of Zucker diabetic fatty (ZDF) rats compared with age matched Zucker lean control (ZLC) rats. Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1767

Platform:

GPL1002

24 Samples

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Analysis of adipose, skeletal muscle, and liver tissues of Zucker diabetic fatty animals at pre-diabetic and diabetic stages. ZDF animals have a mutated leptin receptor. Results provide insight into the molecular mechanisms responsible for insulin resistance and progression to type 2 diabetes.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, log ratio, 2 age, 3 tissue sets

Platform:

GPL1002

Series:

GSE1080

24 Samples

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(Submitter supplied) Objective: The etiology of PCOS is mostly unknown. Existing data support both genetic and environmental factors in its pathogenesis. Design: Prospective case - control study. Setting: University Hospital. Patients: 25 patients undergoing IVF-ICSI treatment. Intervention: Genome-wide oligonucleotide microarray technology was used to study differential gene-expression patterns of cultured human cumulus cells from IVF patients divided into 4 groups according to disease state (PCOS vs. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3841

Platform:

GPL570

23 Samples

Download data: CEL

Analysis of cumulus cells from lean and overweight-obese polycystic ovary syndrome (PCOS) patients undergoing in vitro fertilization (IVF). PCOS is a heterogeneous endocrinopathy in women of reproductive age, mostly associated with ovulation failure. Results provide insight into PCOS pathogenesis.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 2 other sets

Platform:

GPL570

Series:

GSE10946

23 Samples

Download data: CEL

(Submitter supplied) We used microarrays to assess gene expression profiling of 6 patients with a mutation (Arg1174Gln) in the tyrosine kinase domain of the insulin receptor gene (INSR) and 10 matched healthy controls

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4897

Platform:

GPL571

16 Samples

Download data: CEL

Analysis of muscle from patients with a mutation (Arg1174Gln) in the tyrosine kinase domain of the insulin receptor gene (INSR). This mutation is associated with inherited insulin resistance. Results provide insight into molecular mechanisms underlying insulin resistance in skeletal muscle.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL571

Series:

GSE36297

16 Samples

Download data: CEL

(Submitter supplied) Microarray-based studies of skeletal muscle from patients with type 2 diabetes and high-risk individuals have demonstrated that insulin resistance and reduced mitochondrial biogenesis co-exist early in the pathogenesis of type 2 diabetes independent of hyperglycaemia and obesity. It is unknown whether reduced mitochondrial biogenesis or other transcriptional alterations co-exist with impaired insulin-responsiveness in primary human muscle cells from patients with type 2 diabetes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3681

Platform:

GPL8300

20 Samples

Download data: CEL

Analysis of myotube cell lines established from type 2 diabetes (T2D) subjects. Insulin resistance and reduced mitochondrial biogenesis coexist early in T2D pathogenesis independent of hyperglycemia and obesity. Results provide insight into the effect of T2D on developing skeletal muscle cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state sets

Platform:

GPL8300

Series:

GSE12643

20 Samples

Download data: CEL

(Submitter supplied) Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder that affects 5-10% of reproductive aged women. The hallmark characteristic of PCOS is increased ovarian androgen synthesis. Previous studies by our laboratory demonstrated that increased androgen synthesis is a stable biochemical phenotype of PCOS theca cells which are the primary source of ovarian androgen production. The increase in theca cell steroidogenesis was due to an increase in expression of several steroidogenic enzymes including CYP17 and CYP11A but not StAR. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS1050 GDS1051

Platforms:

GPL96 GPL97

26 Samples

Download data: CEL, EXP

Analysis of normal theca cells treated with 500 uM valproic acid (VPA), an anti-epilipetic that induces polycystic ovary syndrome (PCOS)-like symptoms. Theca cells from PCOS patients also examined. Results provide insight into the underlying mechanisms contributing to VPA-induced PCOS-like symptoms.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 2 disease state sets

Platform:

GPL97

Series:

GSE1615

13 Samples

Download data: CEL, EXP

Analysis of normal theca cells treated with 500 uM valproic acid (VPA), an anti-epilipetic that induces polycystic ovary syndrome (PCOS)-like symptoms. Theca cells from PCOS patients also examined. Results provide insight into the underlying mechanisms contributing to VPA-induced PCOS-like symptoms.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 2 disease state sets

Platform:

GPL96

Series:

GSE1615

13 Samples

Download data: CEL, EXP

(Submitter supplied) Global transcript profiling to identify differentially expressed skeletal muscle genes in insulin resistance, a major risk factor for Type II (non-insulin-dependent) diabetes mellitus. Compared gene expression profiles of skeletal muscle tissues from 18 insulin-sensitive versus 17 insulin-resistant equally obese, non-diabetic Pima Indians. Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS157 GDS158 GDS160 GDS161 GDS162

5 related Platforms

50 Samples

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(Submitter supplied) Muscle sample pool #5 from 2 insulin resistant subjects. Keywords: parallel sample

Organism:

Homo sapiens

Type:

Expression profiling by array

5 related Platforms

5 Samples

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