Similar studies for GEO DataSets (Select 200006416) - GEO DataSets

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Items: 20

Select item 2000064161.

Toxicogenomic responses in rainbow trout hepatocytes exposed to model chemicals and a synthetic mixture

(Submitter supplied) Comparison of gene expression of exposed versus non-exposed Oncorhynchus mykiss hepatocytes to four model chemicals and a synthetic mixture. Hepatocytes were exposed for 24 hours to a single chemical and a synthetic mixture of 10 nM 17 alpha-ethinylestradiol (EE2), 0.75 nM 2,3,7,8-tetrachloro-di-benzodioxin (TCDD), 100 μM paraquat and 0.75 μM 4-nitroquinoline-1-oxide (NQO). Keywords: Exposed vs. control

Organism:: Salmo salar; Coregonus clupeaformis; Osmerus mordax; Oncorhynchus mykiss; Oncorhynchus tshawytscha

Type:: Expression profiling by array

Platform:: GPL2716
40 Samples

Download data: TXT

Series

Accession:: GSE6416

ID:: 200006416

Select item 2000138662.

Nickel and binary metal mixtures in Daphnia magna after 96h

(Submitter supplied) The recent development of a custom cDNA microarray platform for one of thé standard organisms in aquatic toxicology, Daphnia magna, opened up new ways to mechanistic insights of toxicological responses. In this study, gene expression and (sub)organismal responses (Cellular Energy Allocation, growth) were assayed after short-term waterborne metal exposure. Microarray analysis of Ni-exposed daphnids revealed several affected functional gene classes, of which the largest ones were involved in different metabolic processes (mainly protein and chitin related processes), cuticula turnover, transport and signal transduction. more...

Organism:: Daphnia magna

Type:: Expression profiling by array

Platform:: GPL7742
21 Samples

Download data: GPR

Series

Accession:: GSE13866

ID:: 200013866

Select item 2000082853.

Short-term growth hormone treatment on the liver and muscle transcriptome in rainbow trout (Oncorhynchus mykiss)

(Submitter supplied) Although studies have established that exogenous growth hormone (GH) treatment stimulates growth in fish, its effects on target tissue gene expression are not well characterized. We assessed the effects Posilac® (Monsanto Co., St. Louis, MO), a recombinant bovine somatotropin, on tissue transcript levels. Transcript abundance was measure in liver and muscle using the GRASP 16 K cDNA microarray. A selection of the genes identified as altered with the microarray, and also transcripts for insulin-like growth factors, growth hormone receptors (GHR) and myostatins were measured by realtime PCR in the liver, muscle, brain, kidney, intestine, stomach, gill and heart. more...

Organism:: Oncorhynchus mykiss; Salmo salar

Type:: Expression profiling by array

Platform:: GPL3976
16 Samples

Download data: TXT

Series

Accession:: GSE8285

ID:: 200008285

Select item 2000048684.

Auratus goldfish genome project: Gene expression profiling in the brain of male goldfish exposed to 17α-EE2

(Submitter supplied) A goldfish brain enriched cDNA combined with a carp microarray (Gracey et al., 2004). Experiment exposed adult male goldfish to 17-alpha ethinylestradiol for two weeks (two doses - 30 ng/L and 300 ng/L) Keywords: estrogenic exposure, dose response,

Organism:: Carassius auratus; Cyprinus carpio

Type:: Expression profiling by array

Platform:: GPL3735
8 Samples

Download data

Series

Accession:: GSE4868

ID:: 200004868

Select item 2000033245.

Toxicogenomic profiling of trout tumor promoters

(Submitter supplied) Indole-3-carbinol (I3C), from cruciferous vegetables, has been found to suppress or enhance tumors in several animal models. We previously reported that dietary I3C promotes hepatocarcinogenesis in rainbow trout (Oncorhynchus mykiss) at concentrations that differentially activated estrogen receptor (ER) or aryl hydrocarbon receptor (AhR)-mediated responses based on individual protein biomarkers. In this study, we evaluated the relative importance of these pathways as potential mechanisms for I3C on a global scale. more...

Organism:: Salmo salar; Oncorhynchus mykiss

Type:: Expression profiling by array

Platform:: GPL966
24 Samples

Download data

Series

Accession:: GSE3324

ID:: 200003324

Select item 2000236136.

Juvenile rainbow trout exposed in situ at site receiving different concentrations of municipal wastewater effluent (MWWE) and an upstream reference site

(Submitter supplied) Juvenile rainbow trout were exposed to MWWE in a caging study, with cages held upstream and downstream of a MWWE outfall for two weeks in the fall of 2007. Whole tissues were sampled and analyzed. Microarray analysis was conducted on liver samples.

Organism:: Oncorhynchus mykiss

Type:: Expression profiling by array

Platform:: GPL3713
16 Samples

Download data: TXT

Series

Accession:: GSE23613

ID:: 200023613

Select item 2000035227.

Gene Expression Profiling Following DNA Vaccination of Rainbow Trout against Infectious Hematopoietic Necrosis Virus

(Submitter supplied) The Infectious Hematopoietic Necrosic Virus (IHNV) DNA vaccine is based on the viral glycoprotein gene (G gene) and induces a non-specific anti-viral immune response and long-term specific immunity against IHNV in salmonid fishes. This study characterized gene expression responses associated with the early anti-viral response. Homozygous rainbow trout were injected intra-muscularly (I.M.) with vector DNA or the IHNV DNA vaccine. more...

Organism:: Oncorhynchus mykiss; Salmo salar

Type:: Expression profiling by array

Platform:: GPL2899
10 Samples

Download data: TXT

Series

Accession:: GSE3522

ID:: 200003522

Select item 2000169038.

Domestication causes large-scale effects on gene expression in rainbow trout

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Salmo salar; Coregonus clupeaformis; Osmerus mordax; Oncorhynchus mykiss; Oncorhynchus tshawytscha

Type:: Expression profiling by array

Platform:: GPL2716
44 Samples

Download data: TXT

Series

Accession:: GSE16903

ID:: 200016903

Select item 2000169019.

Domestication causes large-scale effects on gene expression in rainbow trout: Analysis of the muscle transcriptome

(Submitter supplied) Domestication has produced faster-growing strains of animals for use in agriculture, but selection has been applied with little knowledge of the underlying genetic changes that arose throughout the process. Mammals and birds have been domesticated for thousands of years whereas fish have been domesticated only recently; therefore, wild progenitor strains remain for comparison. Rainbow trout (Oncorhynchus mykiss) have undergone intensive selection and domesticated strains grow more rapidly than extant wild strains. more...

Organism:: Salmo salar; Coregonus clupeaformis; Oncorhynchus tshawytscha; Osmerus mordax; Oncorhynchus mykiss

Type:: Expression profiling by array

Platform:: GPL2716
12 Samples

Download data: TXT

Series

Accession:: GSE16901

ID:: 200016901

Select item 20001689710.

Domestication causes large-scale effects on gene expression in rainbow trout: Analysis of the liver transcriptome

Organism:: Oncorhynchus tshawytscha; Osmerus mordax; Oncorhynchus mykiss; Salmo salar; Coregonus clupeaformis

Type:: Expression profiling by array

Platform:: GPL2716
14 Samples

Download data: TXT

Series

Accession:: GSE16897

ID:: 200016897

Select item 20001688911.

Domestication causes large-scale effects on gene expression in rainbow trout: Analysis of the brain transcriptome

Organism:: Coregonus clupeaformis; Oncorhynchus mykiss; Salmo salar; Osmerus mordax; Oncorhynchus tshawytscha

Type:: Expression profiling by array

Platform:: GPL2716
18 Samples

Download data: TXT

Series

Accession:: GSE16889

ID:: 200016889

Select item 20000722012.

Microarray analysis in the zebrafish liver and telencephalon after exposure to low concentration of 17a-EE2

(Submitter supplied) Experiment exposed adult male zebrafish to 10ng/L 17-alpha ethinylestradiol for three weeks. Gene expression profiling of liver and telencephalon following exposure. Keywords: estrogenic exposure

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL3548
8 Samples

Download data

Series

Accession:: GSE7220

ID:: 200007220

Select item 20002504213.

Identification of novel genes associated with molecular sex differentiation in the embryonic gonads of rainbow trout (Oncorhynchus mykiss)

(Submitter supplied) Abstract. The molecular pathways in embryonic vertebrates leading to gonad formation in each sex are incompletely understood. The purpose of this study was to identify novel genes that could be associated with sex-specific gonadal differentiation in a fish, the rainbow trout (Oncorhynchus mykiss). This study was facilitated by a custom microarray based on 7,681 genes derived from embryonic rainbow trout gonad cDNA libraries and public databases. more...

Organism:: Oncorhynchus mykiss

Type:: Expression profiling by array

Platform:: GPL11151
16 Samples

Download data: CEL

Series

Accession:: GSE25042

ID:: 200025042

Select item 20000295014.

Microarray analysis of mouse ear tissue exposed to bis-(2-chloroethyl) sulfide

(Submitter supplied) Sulfur mustard (SM) is a potent alkylating agent. We are developing medical countermeasures to reduce the injury caused by SM exposure. Screening in the mouse ear vesicant model has identified three effective compounds: dimercaprol (British anti-lewisite), indomethacin, and octyl homovanillamide (OHV). To identify gene expression changes that correlate with compound efficacy we used oligonucleotide microarrays to compare gene expression profiles in vehicle-exposed skin, SM-exposed skin, and skin pretreated with each compound before SM exposure. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL340 GPL339
107 Samples

Download data

Series

Accession:: GSE2950

ID:: 200002950

Select item 20002108415.

Rainbow trout red blood cells (RBCs): Control vs Heat shock, repeated samples from individuals

(Submitter supplied) The retention of a nucleus in the mature state of fish red blood cells (RBCs), and the ability to easily collect and manipulate blood in non-terminal experiments, makes it an ideal tissue on which to study the cellular stress response in fish. Through the use of the cGRASP 16K salmonid microarray, we are currently investigating differences in RBC global gene transcription in fish held under control conditions (12C) and exposed to heat stress (one hour at 25C followed by recovery at 12C). more...

Organism:: Oncorhynchus tshawytscha; Oncorhynchus mykiss; Salmo salar; Osmerus mordax; Coregonus clupeaformis

Type:: Expression profiling by array

Platform:: GPL2716
32 Samples

Download data: TXT

Series

Accession:: GSE21084

ID:: 200021084

Select item 20000840416.

Influence of Water Chemistry on Toxicogenomics of Chronic Lead Toxicity to the Fathead Minnow (Pimephales promelas)

(Submitter supplied) Despite major successes in reducing the risks of lead (Pb) exposure over the past few decades, two issues of considerable importance remain unresolved: (1) how differences in water chemistry influence acute and chronic Pb toxicity, and (2) the elucidation of specific toxic mechanisms and modes of action (MOA). To more clearly define the water chemistry parameters mediating Pb toxicity we evaluated the effects of hardness (as CaSO4) and DOC (as humic acid (HA)) during chronic (150d) exposures to the fathead minnow (Pimephales promelas). more...

Organism:: Pimephales promelas

Type:: Expression profiling by array

Platform:: GPL5443
30 Samples

Download data: GPR

Series

Accession:: GSE8404

ID:: 200008404

Select item 20003892517.

Hepatic gene expression in chinook salmon (Oncorhynchus tshawytscha) exposed to sewage

(Submitter supplied) Hepatic transcriptional profiling of fish exposed to sewage to evaluate temporal and concentration trends.

Organism:: Oncorhynchus mykiss; Oncorhynchus tshawytscha

Type:: Expression profiling by array

Platform:: GPL15697
197 Samples

Download data: TXT

Series

Accession:: GSE38925

ID:: 200038925

Select item 20003016318.

Assessment of chemical mixtures and ground water effects on Daphnia magna transcriptomics

(Submitter supplied) Small organisms can be used as biomonitoring tools to assess chemicals in the environment. Chemical stressors are especially hard to assess and monitor when present as complex mixtures. Here, Daphnia magna were exposed for 24 hours to five different munitions constituents 2,4,6-trinitrotoluene (TNT), 2,4-dinitrotoluene (2,4-DNT), 2,6-dinitrotoluene (2,6-DNT), trinitrobenzene (TNB), dinitrobenzene (DNB), or 1,3,5-trinitro-1,3,5-triazacyclohexane (RDX) as well as to 8 different munitions mixtures and ground water contaminated with munitions constituents. more...

Organism:: Daphnia magna

Type:: Expression profiling by array

Platform:: GPL13761
107 Samples

Download data: TXT

Series

Accession:: GSE30163

ID:: 200030163

Select item 20001316919.

Gene expression profiling in Daphnia magna, Part III: Uncovering Biomarkers for Metal and ORC exposures

(Submitter supplied) To determine toxicant specific effects of Ordnance Related Compound (ORC) exposure we performed microarray hybridizations with RNA isolated from Daphnia magna following different ORC exposures at the 1/10 LC50. The gene expression profiles revealed toxicant specific gene expression profiles allowed for the identification of specific biomarkers of exposure. Keywords: ecotoxicogenomic exposure study

Organism:: Daphnia magna

Type:: Expression profiling by array

Platforms:: GPL3710 GPL5129
70 Samples

Download data: GPR

Series

Accession:: GSE13169

ID:: 200013169

Select item 20003872620.

Toxicity of atrazine and nonylphenol in juvenile rainbow trout (Oncorhynchus mykiss): Effects on general health, disease susceptibility and gene expression

(Submitter supplied) Atrazine (ATZ) and nonylphenol (NP) are commonly identified contaminants in aquatic habitats; however, relatively few studies have considered the impact of these endocrine disrupters on immune function. This study examined the immunotoxicological effects of ATZ and NP at multiple levels of biological organization. Juvenile rainbow trout (Oncorhynchus mykiss) were exposed to a solvent control (0.00625 % v/v anhydrous ethanol), 59 µg/L ATZ, 555 µg/L ATZ, 2.3 µg/L NP or 18 µg/L NP (measured concentrations) for 4 d. more...

Organism:: Oncorhynchus mykiss; Salmo salar

Type:: Expression profiling by array

Platform:: GPL8904
24 Samples

Download data: TXT

Series

Accession:: GSE38726

ID:: 200038726

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