GEO DataSets

Analysis of oocytes following RNAi knockdown of basonuclin (Bnc1), a zinc-finger protein found in abundance in oocytes. The Bnc1 gene qualifies as a maternal-effect gene because the source of pre-implantation embryonic Bnc1 is maternal. Results provide insight into the function of Bnc1.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL1261

Series:

GSE4029

10 Samples

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(Submitter supplied) Basonuclin, which is a zinc-finger protein found in abundance only in the keratinocytes of the stratified epithelium, male germ cells and oocytes, qualifies as a maternal-effect gene because the source of pre-implantation embryonic basonuclin is maternal. Using a transgenic-RNAi approach, we knocked-down basonuclin specifically in mouse oocytes, which led to female sub-fertility. Basonuclin deficiency in oocytes perturbed both RNA polymerase I- and II-mediated transcription and oocyte morphology was affected as evidenced by cytoplasmic and cell surface abnormalities. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1978

Platform:

GPL1261

10 Samples

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(Submitter supplied) Embryos were collected at 2 cell stage. cRNA from four biological replicates of each were generated and the expression profiles were determined using Affymetrix MOE430 v2. Keywords: repeat

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2156

Platform:

GPL1261

8 Samples

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Analysis of two-cell stage embryos maternally depleted for BRG1, a catalytic subunit of SWI/SNF-related chromatin remodeling complexes. After fertilization, the embryo shifts from maternal to zygotic genome expression. Results provide insight into the role of Brg1 in this transition.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE5371

8 Samples

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