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Links from GEO DataSets

Items: 20

1.
Full record GDS1512

Embryonal carcinoma cell line response to retinoic acid or trichostatin A

Analysis of embryonal carcinoma cell line F9 following treatment with all-trans retinoic acid or trichostatin A, a histone deacetylase inhibitor (HDACI). Retinoic acid and HDACIs may be critical regulators of tissue homeostatis and are being tested in clinical trials for a variety of cancers.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 agent sets
Platform:
GPL81
Series:
GSE1437
9 Samples
Download data
2.

HDACI treatment of hepG2 cells

(Submitter supplied) This study compares HEPG2 cells treated with either ethanol(control) or TSA (0.5uM) for 24 hrs. Gene Expression was profiled on HU-133 plus 2.0 arrays Keywords: Treaded vs untreated
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
6 Samples
Download data
Series
Accession:
GSE4465
ID:
200004465
3.

F9 cells after exposure to RA or TSA

(Submitter supplied) F9 cells were exposed to two different differentiating agents (retinoic acid or trichostatin A both dissolved in 100% ethonal) for 24 hrs. Control cells were exposed to ethonal for 24hrs Keywords: repeat sample
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS1512
Platform:
GPL81
9 Samples
Download data
Series
Accession:
GSE1437
ID:
200001437
4.

The role of RIP140 in retinoid mediated signaling

(Submitter supplied) Cell-and context-specific activities of nuclear receptors may in part be due to distinct coregulator complexes recruited to distinct subsets of target genes. RIP140 (also called NRIP1) is a ligand-dependent corepressor that is inducible with retinoic acid (RA). We have shown previously that silencing of RIP140 enhances RA-induced differentiation and enhances the induction of model RA target genes in human embryonal carcinoma cells (EC). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE7500
ID:
200007500
5.

Gene expression analysis of mouse testis after treatment with histone deacetylase inhibitor TSA

(Submitter supplied) Trichostatin A (TSA) is one of the most potent reversible histone deacetylase (HDAC) inhibitors. In male mice, subcutaneous application of TSA is followed by infertility due to apoptosis of pachytene spermatocytes. To get more insight into the mechanisms underlying this phenomenon, we performed a genome-wide expression analysis of murine testes after TSA treatment. The whole genome transcriptome analysis revealed 507 significantly regulated genes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2923
Platform:
GPL4053
10 Samples
Download data
Series
Accession:
GSE5448
ID:
200005448
6.
Full record GDS2923

Testis response to histone deacetylase inhibitor trichostatin A: time course

Analysis of testes at various time points up to 10 hours following subcutaneous injection of the histone deacetylase inhibitor trichostatin A (TSA). TSA treatment is followed by infertility due to the apoptosis of pachytene spermatocytes.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 5 time sets
Platform:
GPL4053
Series:
GSE5448
10 Samples
Download data
DataSet
Accession:
GDS2923
ID:
2923
7.

Expression data from brain tissue of Rattus norvegicus treated with D-Serine

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS3643
Platform:
GPL1355
24 Samples
Download data: CEL
Series
Accession:
GSE10748
ID:
200010748
8.
Full record GDS3643

D-serine effect on the brain: dose response

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 agent, 6 dose sets
Platform:
GPL1355
Series:
GSE10748
24 Samples
Download data: CEL
DataSet
Accession:
GDS3643
ID:
3643
9.

Anti-tumor Activity of Histone Deacetylase Inhibitors in Non-Small Cell Lung Cancer Cells

(Submitter supplied) In order to ascertain the potential for histone deacetylase (HDAC) inhibitor-based treatment in non-small cell lung cancer (NSCLC), we analyzed the anti-tumour effects of Trichostatin A (TSA) and suberoylanilide hydroxamic acid (vorinostat) in a panel of 16 NSCLC cell lines via MTT assay. TSA and vorinostat both displayed strong anti-tumor activities in a proportion of NSCLC cell lines, and suggesting the need for the use of predictive markers to select patients receiving this treatment. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
23 Samples
Download data: CEL
Series
Accession:
GSE10089
ID:
200010089
10.

Anticancer drug clustering in lung cancer based on gene expression profiles and sensitivity database

(Submitter supplied) Anticancer drug clustering in lung cancer based on gene expression profiles. We performed gene expression analysis in lung cancer cell lines. (used: Affymetrix GeneChip Human Genome U133 Array Set HG-U133A). We also examines the sensitivity of these cell lines to commonly used anti-cancer agents (docetaxel, paclitaxel, gemcitabine, vinorelbine, 5-FU, SN38, cisplatin, and carboplatin) via MTT assay. We related the cytoxic activity of each of these agents to corresponding expression pattern in each of the cell lines using modified NCI program. Keywords: cytotoxicity, lung cancer, anticancer drugs
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1688
Platform:
GPL96
29 Samples
Download data: CEL
Series
Accession:
GSE4127
ID:
200004127
11.
Full record GDS1688

Various lung cancer cell lines

Expression profiling of a set of 29 lung cancer cell lines consisting of 10 non-small cell adenocarcinoma, 10 small cell cancer, and 9 squamous cell cancer lines. Gene expression results analyzed in relation to the sensitivity of each cell line to commonly used anti-cancer agents.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 cell line sets
Platform:
GPL96
Series:
GSE4127
29 Samples
Download data: CEL
12.

OCI/AML2 ATRA AND VPA GENE EXPRESSION

(Submitter supplied) Purpose: Treatment of acute promyelocytic leukemia (APL) with the retinoid, all trans retinoic acid (ATRA), along with standard chemotherapy has significantly improved survival compared to chemotherapy alone1. ATRA mediates its benefit in APL by overcoming the transcriptional block mediated by PML-RAR-alpha fusion oncoprotein, thereby, restoring expression of retinoid response genes2. The therapeutic benefits observed with ATRA treatment in APL have not been achieved in the other more common sub-types of acute myeloblastic leukemia (AML)3. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1215
Platform:
GPL96
4 Samples
Download data
Series
Accession:
GSE2668
ID:
200002668
13.
Full record GDS1215

Acute myeloblastic leukemia cells response to all trans retinoic acid and valproic acid

Analysis of acute myeloblastic leukemia (AML) cell line, OCI/AML-2, following treatment with valproic acid (VPA) and all trans retinoic acid (ATRA). VPA inhibits histone deacetylase. Results provide insight into the responsiveness of AML cells to ATRA when VPA is present.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 agent sets
Platform:
GPL96
Series:
GSE2668
4 Samples
Download data
DataSet
Accession:
GDS1215
ID:
1215
14.

Comparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitors

(Submitter supplied) Background Histone deacetylase (HDACs) inhibitors are being intensively pursued as potential new antimalarial drugs, and are also emerging as valuable tools for investigating transcriptional control in malaria parasites. In this study, the genome-wide transcriptional effects of three structurally related hydroxamate HDAC inhibitors were profiled in Plasmodium falciparum, the most lethal of the malaria parasite species that infects humans. more...
Organism:
Plasmodium falciparum
Type:
Expression profiling by array
Platform:
GPL11248
22 Samples
Download data: GPR
Series
Accession:
GSE25642
ID:
200025642
15.

Schistosomula exposed to HDAC inhibitor (Trichostatin A)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Schistosoma mansoni
Type:
Expression profiling by array
Platform:
GPL22001
18 Samples
Download data: TXT
Series
Accession:
GSE83211
ID:
200083211
16.

Schistosomula exposed to HDAC inhibitor (Trichostatin A) [48hrs]

(Submitter supplied) HDACs inhibitors induces mortality in the parasite Schistosoma mansoni (schistosomula and adult worms), and became an interesting drug class for the development of new drugs to treat schistosomiasis. In order to understand the effect of histone hyperacetylation on the parasite, we tested the effect of the HDAC inhibitor Trichostatin A on schistosomula gene expression.
Organism:
Schistosoma mansoni
Type:
Expression profiling by array
Platform:
GPL22001
6 Samples
Download data: TXT
Series
Accession:
GSE83210
ID:
200083210
17.

Schistosomula exposed to HDAC inhibitor (Trichostatin A) [24hrs]

(Submitter supplied) HDACs inhibitors induces mortality in the parasite Schistosoma mansoni (schistosomula and adult worms), and became an interesting drug class for the development of new drugs to treat schistosomiasis. In order to understand the effect of histone hyperacetylation on the parasite, we tested the effect of the HDAC inhibitor Trichostatin A on schistosomula gene expression.
Organism:
Schistosoma mansoni
Type:
Expression profiling by array
Platform:
GPL22001
6 Samples
Download data: TXT
Series
Accession:
GSE83209
ID:
200083209
18.

Schistosomula exposed to HDAC inhibitor (Trichostatin A) [12hrs]

(Submitter supplied) HDACs inhibitors induces mortality in the parasite Schistosoma mansoni (schistosomula and adult worms), and became an interesting drug class for the development of new drugs to treat schistosomiasis. In order to understand the effect of histone hyperacetylation on the parasite, we tested the effect of the HDAC inhibitor Trichostatin A on schistosomula gene expression.
Organism:
Schistosoma mansoni
Type:
Expression profiling by array
Platform:
GPL22001
6 Samples
Download data: TXT
Series
Accession:
GSE83208
ID:
200083208
19.

Testicular germ cell tumors and their histological subgroups

(Submitter supplied) Normal, premalignant and various histological subtypes of testicular germ cell tumor (TGCT) tissues were hybridized against Universal Human Reference RNA (Stratagene) onto Agilent 60mer oligo microarrays (GEO accession no GPL885). In vitro time series of two TGCT cell lines, NTERA2 and 2102Ep, treated with retinoic acid for 0, 3, and 7 days were also included. The data set (30 hybridizations) is particularly useful for comparisons between various histological subtypes of TGCT versus each other or versus normal testis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL885
30 Samples
Download data: TIFF
Series
Accession:
GSE1818
ID:
200001818
20.

Combination of HDAC inhibitors and Azacytidine for Cancer Cell Selective Targeting of Esophageal Cancer Cells

(Submitter supplied) Esophageal cancers (ECs) are highly aggressive tumors with poor prognosis and few treatment options. This study investigated the possibility of treating esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) cells by inhibitors of broad and specific histone deacetylases (HDACi; SAHA, MS-275, FK228) and/or of DNMT (Azacytidine, AZA). Drug targets (HDAC1,2,3 and DNMT1) were present in non-neoplastic (HET-1A), ESCC (OE21) and EAC (OE33) cell lines. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
36 Samples
Download data: TXT
Series
Accession:
GSE57130
ID:
200057130
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