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Links from GEO DataSets

Items: 10

1.
Full record GDS1338

T cell anergy induction regulation by Egr-2 and Egr-3 (MG-U74B)

Analysis of pooled mRNA (2, 4, 6 hours) from A.E7 T cell clones activated in conditions that promote (anti-TCR) or inhibit (anti-TCR + CsA or PKCi or Combo) anergy induction. Results identify the early growth response gene 2 (Egr-2) and Egr-3 as key positive regulators of T cell anergy induction.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 5 agent, 3 protocol sets
Platform:
GPL82
Series:
GSE2323
5 Samples
Download data
DataSet
Accession:
GDS1338
ID:
1338
2.

Anergy Induction

(Submitter supplied) pooled mRNA (2, 4, 6 hrs) from A.E7 T cells under conditions which promote or inhibit anergy induction Keywords: ordered
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS1336 GDS1338 GDS1339
Platforms:
GPL82 GPL83 GPL81
15 Samples
Download data
Series
Accession:
GSE2323
ID:
200002323
3.
Full record GDS1339

T cell anergy induction regulation by Egr-2 and Egr-3 (MG-U74C)

Analysis of pooled mRNA (2, 4, 6 hours) from A.E7 T cell clones activated in conditions that promote (anti-TCR) or inhibit (anti-TCR + CsA or PKCi or Combo) anergy induction. Results identify the early growth response gene 2 (Egr-2) and Egr-3 as key positive regulators of T cell anergy induction.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 5 agent, 3 protocol sets
Platform:
GPL83
Series:
GSE2323
5 Samples
Download data
DataSet
Accession:
GDS1339
ID:
1339
4.
Full record GDS1336

T cell anergy induction regulation by Egr-2 and Egr-3 (MG-U74A)

Analysis of pooled mRNA (2, 4, 6 hours) from A.E7 T cell clones activated in conditions that promote (anti-TCR) or inhibit (anti-TCR + CsA or PKCi or Combo) anergy induction. Results identify the early growth response gene 2 (Egr-2) and Egr-3 as key positive regulators of T cell anergy induction.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 5 agent, 3 protocol sets
Platform:
GPL81
Series:
GSE2323
5 Samples
Download data
DataSet
Accession:
GDS1336
ID:
1336
5.

RNA sequencing of T cells in the genetically encoded mouse model of T cell anergy (W131AOTII)

(Submitter supplied) We found that gene signatures characteristic of unresponsive cells were strongly enriched in peripheral W131AOTII CD4 T cells but not in CD4 single positive (CD4SP) thymocytes. Furthermore, loss of Cbl-b in W131AOTII mice significantly altered gene expression profile associated with improved T cell responsiveness.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
18 Samples
Download data: TXT
Series
Accession:
GSE167169
ID:
200167169
6.

Kinetic analysis of T cell anergy induction

(Submitter supplied) T cell receptor(TCR) engagement in the absence of costimulation leads to a state of T cell tolerance known as anergy. Anergy induction requires new protein synthesis since it is inhibited by cycloheximide. In this experiment, we tried to figure out kinetic properties of the gene expression in anergy induction phase and the subsequent anergy maintenance phase.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL83 GPL81 GPL82
15 Samples
Download data: CEL
Series
Accession:
GSE72731
ID:
200072731
7.

Role of EGR2 transcription factor in T cell anergy

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array
Platforms:
GPL9185 GPL1261
15 Samples
Download data: BED, CEL, CHP
Series
Accession:
GSE46243
ID:
200046243
8.

Egr2-dependent expression in T cell anergy

(Submitter supplied) T cell anergy is one of the mechanisms contributing to peripheral tolerance, particularly in the context of progressively growing tumors and in tolerogenic treatments promoting allograft acceptance. We recently reported that early growth response gene 2 (Egr2) is a critical transcription factor for the induction of anergy in vitro and in vivo, which was identified based on its ability to regulate the expression of inhibitory signaling molecules diacylglycerol kinase (DGK)-a and -z. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE46242
ID:
200046242
9.

Genome-wide maps of EGR2 transcription factor binding sites in T cell anergy

(Submitter supplied) We report the application of sequencing technology for mapping the EGR2 transcriptional program in T cell anergy
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9185
3 Samples
Download data: BED
Series
Accession:
GSE46241
ID:
200046241
10.

Expression data of CLL cells with and without NFAT2 expression

(Submitter supplied) Chronic lymphocytic leukemia (CLL) is a disorder of mature B cells. Most patients are characterized by indolent disease and an anergic phenotype of their leukemia cells which refers to a state of unresponsiveness to B cell receptor stimulation. Using the Eµ-TCL1 mouse model, we show that B cell-specific ablation of NFAT2 leads to the loss of the anergic phenotype culminating in a significantly compromised life expectancy and histological transformation to aggressive disease. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL, XLS
Series
Accession:
GSE86210
ID:
200086210
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Supplemental Content

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