Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle [RNAseq] - - GEO DataSets

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Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle [RNAseq]

(Submitter supplied) Dissecting the myriad regulatory mechanisms controlling eukaryotic transcripts from production to degradation requires quantitative measurements of mRNA flow across the cell. We developed subcellular TimeLapse-seq to measure the rates at which RNAs are released from chromatin, exported from the nucleus, loaded onto polysomes, and degraded within the nucleus and cytoplasm. These rates varied substantially, yet transcripts from genes with related functions or targeted by the same transcription factors and RNA binding proteins flowed across subcellular compartments with similar kinetics. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
51 Samples

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Accession:: GSE231290

ID:: 200231290

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