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ADAR1 biology can hinder effective antiviral RNA interference

(Submitter supplied) Viruses constantly evolve and adapt to the antiviral defenses of their hosts. The biology of viral circumvention of these selective pressures can often be attributed to the acquisition of novel antagonistic gene products or by rapid genome change that prevents host recognition. To study viral evasion of RNA interference (RNAi)-based defenses, we established a robust antiviral system in mammalian cells using recombinant Sendai virus designed to be targeted by endogenous host microRNAs (miRNAs) with perfect complementarity. more...
Organism:
Homo sapiens; Mus musculus; Canis lupus familiaris
Type:
Expression profiling by high throughput sequencing
5 related Platforms
45 Samples
Download data: CSV, SF
Series
Accession:
GSE227592
ID:
200227592

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