Chromatin Loop Extrusion Plays a Fundamental Mechanistic Role in Antibody Class Switching [3C-HTGTS] - - GEO DataSets

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Chromatin Loop Extrusion Plays a Fundamental Mechanistic Role in Antibody Class Switching [3C-HTGTS]

(Submitter supplied) In a B lymphocyte immunoglobulin heavy chain locus (IgH), a developmentally assembled V(D)J exon encoding an antibody variable region lies upstream of exons encoding a m constant region (Cm), allowing generation of mIgH chain transcripts and IgM-class antibodies1. Mouse IgH class switch recombination (CSR) replaces Cmwith one of 6 sets of constant region exons (CHs) that lie 100-200kb downstream1. more...

Organism:: Mus musculus

Type:: Genome variation profiling by high throughput sequencing

Platforms:: GPL16417 GPL21626
75 Samples

Download data: BEDGRAPH

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Accession:: GSE130263

ID:: 200130263

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