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Modulation of global transcriptional regulatory networks as a strategy for increasing kanamycin resistance of EF-G mutants

(Submitter supplied) Evolve and resequence experiments have provided us a tool to understand bacterial adaptation to antibiotics by the gain of genomic mutations. In our previous work, we used short term evolution to isolate mutants resistant to the ribosome targeting antibiotic kanamycin. We had reported the gain of resistance to kanamycin via multiple different point mutations in the translation elongation factor G (EF-G). more...
Organism:
Escherichia coli str. K-12 substr. MG1655
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21117
18 Samples
Download data: TXT
Series
Accession:
GSE82343
ID:
200082343

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