Retinoic acid signaling coordinates the behavior of multiple cell lineages during cardiac outflow morphogenesis - - GEO DataSets

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Retinoic acid signaling coordinates the behavior of multiple cell lineages during cardiac outflow morphogenesis

(Submitter supplied) Retinoic acid (RA), the bioactive derivative of vitamin A, is essential for vertebrate heart development. Both excess and reduced RA signaling lead to cardiovascular malformations, particularly affecting the cardiac outflow tract (OFT). The cellular mechanisms underlying the effects of RA signaling during OFT morphogenesis are not fully understood. To address this question, we used transient maternal RA supplementation to rescue the early lethality resulting from inactivation of the murine retinaldehyde dehydrogenase 2 (Raldh2) gene. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13912
8 Samples

Download data: TXT

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Accession:: GSE64556

ID:: 200064556

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