GEO DataSet Links for BioProject (Select 248290) - GEO DataSets

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Items: 2

Select item 2000578631.

MMSET regulation of gene expression in t(4;14)+ myeloma

(Submitter supplied) We investigated gene expression in isogenic myeloma cell lines with or without overexpressed MMSET protein. MMSET is a histone methyltransferase which methylates lysine 36 on histone H3. Overexpression of MMSET in myeloma leads to a global increase in H3K36 methylation and concomitant decrease in H3K27 methylation. These global changes in histone methylation lead to altered gene expression.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5219
Platform:: GPL6884
12 Samples

Download data: TXT

Series

Accession:: GSE57863

ID:: 200057863

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 52192.

Histone methyltransferase MMSET overexpression effect on KMS11 multiple myeloma cell line

Analysis of KMS11 t(4;14) MM parental cell line with a normal overexpressed multiple myeloma SET domain containing protein (MMSET) and cell lines knocked out for MMSET on the translocated allele (TKO) or on the non-translocated allele (NTKO). Results provide insight into role of MMSET in t(4;14) MM.