GEO DataSet Links for BioProject (Select 190058) - GEO DataSets

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Items: 2

Select item 2000445611.

Effect of Notch1 pathway activation on high-grade glioma cells

(Submitter supplied) In this study, we explored the transcriptomic consequences of strong activation of the Notch pathway in embryonic human neural stem cells and in gliomas. For this we used a forced expression of the Notch intracellular domain (NICD). Glioblastoma multiforms (GBMs) are highly vascularized brain tumors containing a subpopulation of multipotent cancer stem cells. These cells closely interact with endothelial cells in neurovascular niches. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5671
Platform:: GPL11532
8 Samples

Download data: CEL, CHP

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Accession:: GSE44561

ID:: 200044561

Select item 56712.

Notch1 stimulation effect on glioblastoma stem cell cultures

Analysis of Gb4 and Gb7 glioma cancer stem cells following forced expression of the Notch1 intracellular domain (NICD) to activate the Notch1 signaling pathway. Results provide insight into a role for the Notch1 pathway in glioblastoma stem cell plasticity and angiogenic properties.